Neurological pain disorder

This trial tests whether a brief counseling session followed by an 8-week smartphone program can help rural adults who drink heavily and live with chronic pain. Participants are recruited online and complete all study steps through videoconferencing. After a first assessment, the…

This study tests a smoking cessation program designed for veterans who have chronic pain. Participants receive counseling over the phone plus nightly automated calls to report their smoking and pain levels. The goal is to see if this approach helps more veterans quit smoking comp…

This trial asks whether continuing BurstDR spinal cord stimulation—a therapy that uses an implanted device to send electrical pulses to the spine—actually relieves chronic pain better than a sham (inactive) stimulation. Adults who already have the device and have experienced good…

This trial compares two interventional treatments for chronic migraine: ultrasound-guided pulsed radiofrequency (PRF) targeting the greater occipital and supratrochlear nerves, versus Botox (onabotulinumtoxinA) injections. The study enrolls adults aged 18-65 with chronic migraine…

This pilot trial tests whether a wearable device that sends mild electrical pulses to the upper arm can prevent migraine headaches in children and adolescents when used during the early warning phase (prodrome). About 30 youth with migraine will use either the active device or a …

This study tests whether a single infusion of eptinezumab, given within 8 weeks of a mild brain injury, can reduce headache days and prevent short-term post-traumatic headaches from becoming long-term. About 80 adults with migraine-like post-traumatic headaches will receive eithe…

This trial is testing whether taking a daily Ceylon cinnamon supplement, combined with a structured educational program, can improve blood sugar control, cholesterol levels, and nerve pain in adults with type 2 diabetes and painful diabetic peripheral neuropathy. About 900 partic…

This trial is testing an investigational drug called KL0011034, given by infusion, alongside the opioid alfentanil in people with moderate-to-severe chronic pain that is not caused by cancer. The study aims to see how the two drugs interact in the body, and whether the combinatio…

This trial tests whether rimegepant, a newer migraine medication, works as well as flunarizine, an older preventive, for reducing days with moderate-to-severe dizziness in people with vestibular migraine. About 400 adults aged 18 to 75 will take one of the two drugs daily for 12 …

This trial tests whether trigger point bloodletting—a procedure that pricks and cups specific facial points—can reduce pain in people with trigeminal neuralgia, a condition causing severe facial pain. Adults aged 18-75 with classic trigeminal neuralgia and trigger points in the u…

This study tests whether a daily probiotic supplement, Bifidobacterium adolescentis PRL2019, can reduce pain in young people aged 9 to 25 with juvenile fibromyalgia, a condition marked by widespread musculoskeletal pain. Participants will take the probiotic or a placebo for 12 we…

This study tests a stepwise injection plan for adults with joint hypermobility and instability who haven't improved enough with physical therapy. The first step uses dextrose prolotherapy to stimulate healing in ligaments. If that doesn't reduce pain by at least 40%, participants…

This study looks at how well atogepant, a daily pill, works to prevent migraines in adults treated in UK primary care. About 200 people with migraine will take atogepant as prescribed by their doctor and report their symptoms and healthcare use for up to 48 weeks. The goal is to …

This trial tests whether taking two inexpensive migraine prevention drugs together works better than taking either one alone. Adults aged 18 to 55 who have at least four migraines per month will receive propranolol, flunarizine, or both for 12 weeks. The goal is to see which appr…

This study tests whether a set of dietary supplements taken at different phases of a migraine cycle can improve quality of life and reduce headache days in adults with migraine. Participants take a daily foundational supplement, with additional supplements during the luteal phase…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This study tests whether a patch made from a patient's own platelet-rich plasma works better than a standard whole blood patch for treating spontaneous intracranial hypotension, a condition causing severe headaches from spinal fluid leaks. About 218 adults who haven't improved wi…

This pilot study tests a procedure called TEMMA, where doctors insert small coils into an artery in the lining of the brain to treat migraine. The study will enroll 25 adults aged 18-60 who have migraine at least 8 days per month and have not gotten relief from at least two preve…

This study compares two common stitch materials—absorbable Vicryl and non-absorbable Prolene—for closing the abdominal wall after surgery. Researchers will track 156 patients in Pakistan for 6 months to see which suture leads to fewer hernias, infections, and less pain. The goal …

This trial tests whether an investigational imaging agent called [18F]FTC-146, used with a PET/MRI scan, can identify the specific nerves responsible for chronic pain. Participants with chronic pain lasting at least two months will receive a single injection of the agent and unde…

This study tests a free, mobile-friendly digital tool designed to help healthcare providers quickly determine the right level of care for people with chronic pain. The tool uses five standard questionnaires to generate a recommendation—from primary care to specialist referral. Re…

This study tests a new way to inject numbing medicine directly into a specific nerve root to find out which nerve is causing back and leg pain. The goal is to see if this method is safer and more accurate than current techniques. About 80 adults with sciatica who are scheduled fo…

Trigeminal neuralgia causes sudden, severe facial pain often mistaken for a toothache, leading to wrong treatments. This study tests a 15-question screening tool in 250 adults with facial pain to see if it can accurately identify possible trigeminal neuralgia before a specialist …

This study aims to see if common physical exams and diagnostic criteria can accurately identify piriformis syndrome, a cause of buttock pain. Researchers will enroll 75 adults with gluteal pain and compare exam results to an ultrasound-guided lidocaine injection into the piriform…

This pilot study tests whether placing a soft tissue matrix over a nerve during forearm flap surgery can prevent chronic pain and numbness. Eighty head and neck cancer patients will be randomly assigned to receive either the matrix or standard closure. The main goal is to see if …

This trial tests whether applying a 5% lidocaine plaster daily for two months can prevent chronic nerve pain after an osteoporotic vertebral fracture. Participants aged 50 and older with a recent fracture and moderate pain are randomly assigned to receive the plaster plus standar…

This study tests whether a single injection of fremanezumab, a drug used to prevent migraines, can stop acute mountain sickness (AMS) in healthy adults. Thirty volunteers will receive either the drug or a placebo one week before climbing to a high-altitude hut. Researchers will t…

This study tests whether adding an ultrasound-guided nerve block (Pecs block) to a ketamine infusion can prevent chronic pain after breast cancer surgery. 120 women scheduled for mastectomy will be randomly assigned to receive either ketamine alone or ketamine plus the nerve bloc…

This study tests whether a gentle electrical brain stimulation technique called tDCS, given alongside standard rehab, can prevent the development of chronic neuropathic pain after a stroke. Sixty adults who recently had a stroke will receive either real or sham tDCS for 10 sessio…

This trial tests whether adding a structured yoga therapy program to standard surgery for endometriosis can reduce chronic pain and improve quality of life. About 188 women scheduled for endometriosis surgery will either receive standard care alone or standard care plus 32 guided…

This trial tests whether a smartphone-based mindfulness program can help adolescents and young adults with sickle cell disease manage chronic pain and sleep problems. Participants are randomly assigned to either use the mindfulness app for about 8 weeks or receive usual care. The…

Researchers are testing whether a noninvasive device called Hypersound can reduce chronic neuropathic or radicular pain in adults. The system uses external antennas to deliver radiofrequency energy to peripheral nerves without implants or needles. About 71 participants receive te…

Researchers at the University of Miami are testing a non-invasive ear stimulation treatment to understand nerve pain in older adults living with HIV. The study enrolls 70 people with HIV-associated peripheral neuropathy, a condition that causes tingling, numbness, or pain in the …

Stanford researchers are testing whether a single 120-minute pain relief class called Empowered Relief can help women with severe pain after cesarean delivery. The class teaches pain education, relaxation, deep breathing, and cognitive behavioral skills, and participants receive …

Researchers are testing whether Qigong, a mind-body exercise, can improve spinal mobility and reduce pain in women with fibromyalgia. The trial randomly assigns 36 women aged 30 to 50 to one of two online Qigong programs: one focused on fluid, mobility-intensive movements, the ot…

This study tests whether a supplement called FibroThol (containing 2-Aticyto Complex and D-ribose) can help reduce pain and other symptoms in people with fibromyalgia. About 200 adults aged 18 to 65 who have had fibromyalgia for at least a year and are already on standard medicat…

This trial tests whether a single, two-hour online class called Empowered Relief can help American Indian adults with cancer-related pain. Participants learn three pain relief skills, create a personal plan, and get access to a free audio app for daily practice. The study aims to…

This pilot trial tests whether adding virtual pain neuroscience education to standard spinal cord stimulation can help chronic pain patients better manage their condition. The education teaches how the brain processes pain, aiming to reduce fear, anxiety, and catastrophizing. Par…

Researchers at Dana-Farber Cancer Institute are testing Healing Gardens, a mobile game that delivers pain-focused cognitive behavioral therapy and cancer pain education. The study enrolls 46 adults with advanced solid tumors who have chronic pain related to cancer or its treatmen…

This Phase 3 trial will test a web-based program called IMPACT for 250 veterans who have both opioid use disorder and chronic pain. The program includes 9 online modules and weekly feedback from a coach, all done from home. The goal is to see if it reduces how much pain interfere…

Many burn survivors live with persistent pain that disrupts daily life, and negative thoughts about pain can make it worse. Researchers are testing an 8-week cognitive behavioral therapy program delivered by video to see if it reduces pain interference and pain catastrophizing mo…

Researchers at the University of North Carolina at Chapel Hill are testing whether daily exposure to S-cone stimulating colored light can reduce pain severity and pain sensitivity in adults with fibromyalgia or chronic widespread pain and fatigue. Participants use programmed ligh…

Researchers at the University of Michigan are studying whether a home device called Transcutaneous Electrical Acustimulation (TEA) can help adults with cirrhosis manage chronic pain. The trial enrolls 100 people who report ongoing pain on most days. Participants use either a real…

This trial tests whether an experimental oral drug called BR005-036C can quickly relieve migraine attacks in adults. Researchers will compare two doses of the drug against a placebo in about 2,079 people who have migraines with or without aura. The main goals are to see if the dr…

Researchers are testing a culturally adapted physiotherapy program for Somali women in Norway who have chronic pelvic pain. The program combines guided exercise, home exercise three times a week, pelvic floor muscle training, and pain education. Thirty women aged 18 to 45 will ta…

Complex regional pain syndrome (CRPS) causes severe, lasting pain and can distort how people perceive the affected body part. Researchers are testing whether graded motor imagery, a rehabilitation approach that uses mental exercises and mirror therapy, can improve body perception…

This study tests whether a single session of low-intensity focused ultrasound (LIFU) can safely reduce chronic pain and anxiety symptoms. Ten adults with either generalized anxiety disorder or chronic pain will receive multiple ultrasound pulses in one visit and be followed for s…

Researchers are testing an oral drug called elismetrep (K-304) to see if it can quickly relieve moderate or severe migraine attacks. The Phase III trial enrolls about 1,500 adults aged 18 to 75 who have had migraines for more than a year. Participants receive either elismetrep or…

Researchers are testing whether adding a procedure called interfascial hydrodissection to a standard ultrasound-guided piriformis injection helps adults with piriformis syndrome. The trial enrolls 110 people aged 18 to 70 who have buttock pain and signs of piriformis syndrome. Ev…

Researchers at Assiut University are studying whether scar-like arachnoid tissue can tether the trigeminal nerve and cause facial pain in people whose MRI scans show no blood vessel pressing on the nerve. Adults with trigeminal neuralgia that has not responded to medication can j…

This study tests an experimental drug called SP-102 for people with moderate to severe sciatica (leg and back pain). About 755 adults will receive a single injection of SP-102, a placebo, or an active comparator. The goal is to see how well SP-102 reduces pain and improves daily …

Researchers at Stanford University are testing whether a single 120-minute pain relief skills class, called Empowered Relief, can help women who have ongoing pain after a cesarean delivery. The class teaches pain education, relaxation techniques, and cognitive strategies to refra…

This trial tests whether adding sensorimotor training to standard physical therapy helps people with sciatica from a herniated disc walk better and feel less pain. Researchers will compare two groups of 30 adults aged 30 to 55 with radiating leg pain lasting over three months. On…

This study tests a mobile app called DockTales, designed for adults with chronic pain. The app lets users track pain and sleep through short diaries, body maps, and journaling, with an optional AI feature for reflection. Researchers want to see if the app is easy to use and engag…

This trial tests whether an 8-week lifestyle program can reduce the burden of chronic migraine, a condition marked by headaches on at least 15 days per month. Adults aged 18 to 55 with chronic migraine will be randomly assigned to either the lifestyle program or a wait-list contr…

This trial tests whether a lidocaine gel applied to the feet can ease painful diabetic neuropathy as well as the oral drug duloxetine. Adults with type 2 diabetes and moderate-to-severe nerve pain will be randomly assigned to one of the two treatments for 8 weeks. Researchers wil…

Researchers at Yale University are testing whether cognitive behavioral therapy for migraine (CBTm) can improve quality of life for veterans with episodic migraine. The study compares CBTm, a six-session behavioral program, to a digital migraine education intervention. Participan…

Researchers are testing whether a single session of connective tissue massage on the back can immediately reduce pressure pain sensitivity in women with fibromyalgia. The trial will measure pain thresholds at the trapezius, lower back, and shin before and after the massage, compa…

This study tests whether a smartphone app that plays personalized music can help people with HIV manage chronic pain. Sixty participants will either use the music app daily for 3 months or receive educational materials about pain. The main goal is to see if the app is practical a…

This trial tests two non-drug approaches for pelvic floor myofascial pain in women who gave birth at least two weeks earlier. Researchers compare low-intensity extracorporeal shockwave therapy with traditional acupuncture, both targeting specific acupoints. Participants receive o…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This trial tests whether a non-invasive brain stimulation technique called intermittent theta-burst stimulation (iTBS) can reduce lower-limb spasticity and neuropathic pain in people with multiple sclerosis. About 40 adults with MS and significant leg stiffness and pain will rece…

This study tests whether dexamethasone palmitate, a steroid, can better relieve shingles pain and prevent long-term nerve pain compared to standard care. About 954 adults with shingles rash and severe pain will receive the drug by injection or infusion. Researchers will track pai…

This study tests whether using a virtual reality headset to practice a type of mindfulness therapy called Acceptance and Commitment Therapy (ACT) can reduce migraine-related disability. About 160 adults with episodic migraine will either continue their usual care or add VR sessio…

This trial tests whether a daily oral cannabis extract with a 5:1 CBD-to-THC ratio can reduce chronic pain in women aged 45 to 80 who haven't found relief from standard treatments. Participants will receive either the cannabis extract or a placebo in a crossover design, allowing …

This phase 2 trial tests whether low sodium oxybate (Xywav) can reduce nighttime cluster headache attacks in people with chronic cluster headache. About 52 participants will receive either the drug or a placebo for 16 weeks. The main goal is to see if the drug lowers the number o…

This study tests whether a type of hands-on physical therapy applied to the spine can reduce headache pain and improve daily function in women with episodic migraine. Ten women aged 18 to 30 will receive 10 sessions of spinal manual therapy over two weeks, with follow-up assessme…

This trial tests whether adding a brief, skills-based cognitive behavioral therapy (CBT) session to standard transitional pain care helps people recovering from surgery. Participants are adults with chronic pain or a history of substance use who take daily opioids. The study comp…

This pilot trial compares an adapted form of mindfulness-based cognitive therapy with a health education program in older Black adults who have chronic pain and early cognitive decline. The goal is to see if the mindfulness approach can improve quality of life and reduce how much…

This trial tests whether adding mental training—watching movement videos and imagining performing exercises—to standard physiotherapy can improve outcomes for people with cervical disc herniation and chronic neck pain. Thirty-six adults will be split into two groups: one receivin…

This study tests whether taking a daily capsule of decaffeinated green tea extract can reduce nerve pain in people who have had cancer treatment. The trial enrolls 20 adults with stable pain who are not currently undergoing cancer therapy. Participants receive either the green te…

This study tests a new program called Empowered Relief for Caregivers (ER-CY), a single two-hour online class for caregivers of children and teens with chronic pain. Up to 80 caregivers will take the class and complete surveys and interviews over three months. The goal is to see …

This trial tests whether a neck-focused rehabilitation program can reduce the burden of chronic migraine. Adults aged 18-55 with chronic migraine will be randomly assigned to either an eight-week program of cervical sensorimotor exercises or conventional physiotherapy. The study …

This study tests whether two hands-on therapies—muscle energy technique and myofascial release—can improve pain, muscle strength, and activation in people with piriformis syndrome, a condition where a deep buttock muscle irritates the sciatic nerve. About 72 adults aged 18–65 wit…

This trial tests whether applying a numbing medicine (lidocaine) to a nerve cluster inside the nose can quickly relieve migraine headaches, facial pain, and neck pain. Adults who have frequent headaches and facial pressure will receive either lidocaine or a saltwater placebo duri…

This trial tests whether adding a second nerve block—targeting the greater auricular nerve—to the standard occipital nerve block provides better pain relief for people with chronic migraine. About 80 adults with chronic migraine will receive either the combined block or the stand…

This trial tests whether duloxetine, an FDA-approved osteoarthritis drug, can improve walking ability and physical activity in people with chronic knee osteoarthritis pain. Participants take duloxetine or a placebo for six weeks, then complete surveys, physical tasks, brain imagi…

This study looks at whether different doses of steroid injections work equally well for treating sciatica (nerve pain in the lower back and leg). About 150 adults with MRI-confirmed lumbar radiculopathy who have not had back surgery will receive one of several doses of either tri…

This trial tests whether a daily supplement containing curcumin (from turmeric) and piperine (from black pepper) can reduce pain and improve quality of life in women with fibromyalgia. Participants will be randomly assigned to receive either the active supplement or a placebo for…

This study tests whether a fully virtual mindfulness program (BREATHE-HA) is feasible and acceptable for teens aged 12–17 with migraine. Participants will either join a 6-session mindfulness group or a headache education group, both delivered via telehealth. The goal is to see if…

This study tests a device called Scrambler Therapy to relieve nerve pain in children with cancer that has spread to the bone. The treatment is non-invasive and aims to lower pain levels and reduce the need for pain medications. About 70 children who can describe their pain will t…

This study will test whether a 24-week Tai Chi program can reduce chronic pain, improve thinking and mobility, and lower fall risk in older adults (65+) who have pain in multiple body areas and are at risk for falls. 266 participants will be randomly assigned to Tai Chi or light …

This trial tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce the number of headache days in people with chronic migraine. Participants will receive either real or sham (inactive) stimulation over the motor co…

This study tests a device called BreEStim that uses electrical stimulation timed with your breathing to reduce nerve pain after spinal cord injury. About 66 adults with long-term spinal cord injury and stable pain will receive either active or sham treatment. The goal is to see i…

This trial tests whether a non-invasive brain stimulation technique called temporal interference stimulation (tTIS) can reduce neuropathic pain—pain caused by nerve damage. Researchers will monitor changes in pain levels and brain plasticity in 60 adults with peripheral neuropath…

This phase III trial tests whether a daily probiotic supplement, OXXYSLAB®, can reduce peripheral neuropathy—nerve damage causing pain and numbness—in people with stage III colon cancer receiving oxaliplatin-based chemotherapy (FOLFOX or XELOX). About 130 participants will take e…

This trial tests whether adding mandala coloring sessions to usual care can reduce pain, fatigue, and sleep troubles in adults with fibromyalgia. Sixty participants will be randomly assigned to either eight supervised coloring sessions over four weeks or to continue their routine…

This study looks at people with migraines who also have a small hole in the heart (PFO). Participants first take a blood-thinning drug (prasugrel) to see if their migraines improve. Those who respond are randomly assigned to either continue the drug alone or have a procedure to c…

This trial tests a program called ENCompaSS that combines education, phone coaching, and self-management tips to help Veterans with long-term back pain. Participants are randomly assigned to either the program plus usual care or usual care alone. The study measures whether the pr…

This trial tests whether a wearable device that gently stimulates the vagus nerve through the ear can reduce pain and PTSD symptoms in veterans who have both conditions. Participants receive six sessions of a brief PTSD therapy along with either active or sham stimulation over fo…

This trial tests whether a meditation-based program called Mantram Repetition Program (MRP) can help veterans who have both posttraumatic stress disorder (PTSD) and chronic pain. Participants will be randomly assigned to either MRP or a health education group. The study measures …

This trial tests whether a single injection of platelet-rich plasma (PRP), made from a woman's own blood, can reduce pain and improve healing after perineal tears or episiotomies during vaginal birth. About 160 women will receive either PRP or a placebo injection right after deli…

This trial tests whether pain reprocessing therapy (PRT) — a brief psychological treatment that combines education, cognitive restructuring, and body-focused techniques — can reduce chronic pain. Adults with persistent pain lasting over three months are randomly assigned to full …

This trial tests three dry needling methods—dynamic, static, and a mix—for treating orofacial myofascial pain, a common jaw muscle condition. Forty-five adults with active trigger points in their chewing muscles will receive one technique. The study measures pain intensity, press…

This early study tests a brain stimulation device for people with long-term nerve pain that hasn't responded to other treatments. The device is surgically placed to send mild electrical pulses to specific brain areas. The main goal is to see if the procedure is feasible and accep…

This pilot study tests whether zavegepant nasal spray can quickly relieve pain from episodic cluster headaches. About 40 adults with episodic cluster headaches will use the spray at the start of an attack. The main goal is to see how many achieve minimal or no pain within 30 minu…

This study tests two types of brain training—motor imagery (mentally picturing movements) and sensorimotor training (repetitive sensory exercises)—against standard therapy for people with multiple sclerosis who have neuropathic pain in their legs. The goal is to see which approac…

This study tests whether adding a gentle electrical stimulation to the ear — targeting the vagus nerve — can improve pain and function in adults with complex regional pain syndrome type I (CRPS-I) affecting the hand or arm. All participants receive standard rehabilitation, but ha…

This study tests whether pulsed radiofrequency (PRF) — a procedure that uses electrical pulses to calm nerves — can relieve sacroiliac joint pain better than standard steroid injections. Adults aged 18 to 65 with chronic pain lasting at least 6 months and a pain score above 5 out…

This trial investigates whether high-intensity peripheral magnetic stimulation can reduce pain and improve function in adults with traumatic peripheral nerve injury. Participants receive either active or sham magnetic stimulation alongside a standard exercise program. The study m…

This study develops and tests a program called MBCT-TIP, which combines mindfulness-based cognitive therapy with trauma-informed care for adults who have chronic pain and a history of intimate partner violence. Participants attend eight weekly group sessions and complete assessme…

This trial tests F-GYN, a single-use injectable gel made of non-crosslinked hyaluronic acid, for women with moderate to severe vaginal dryness and atrophy. Participants either receive the injection right away or continue standard non-hormonal care for 4 weeks before getting the i…

This trial investigates whether the drug crisugabalin can reduce neuropathic pain in people with neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune condition affecting the nerves. Participants will receive either crisugabalin or a placebo, and their pain levels wil…

This pilot study tests a 12-week program that combines a pain education booklet with exercise therapy for adults with chronic nociplastic pain. The program covers pain science, goal setting, sleep, stress, diet, and physical activity. Researchers want to see if the approach is fe…

This study investigates whether major ozone autohemotherapy — a procedure where a small amount of blood is mixed with ozone and returned to the body — can improve pain, fatigue, sleep, and muscle health in women with fibromyalgia. Sixty participants will receive either exercise a…

This study tests whether an artificial intelligence (AI) and computer vision system can help people with fibromyalgia perform effective exercise at home. Participants use a smartphone or tablet app that watches their movements and gives real-time feedback, with or without added r…

This study compares two manual therapy techniques—myofascial release and post-isometric relaxation—for treating piriformis syndrome, a condition where a muscle in the buttock presses on the sciatic nerve, causing pain, numbness, and tingling. Twenty-six adults aged 20 to 50 with …

This study investigates whether giving lidocaine or dexmedetomidine through a vein during urethral reconstruction surgery can lower pain right after surgery and reduce the chance of chronic pain lasting months later. About 80 adults scheduled for this surgery will receive one of …

This trial compares three treatments for idiopathic trigeminal neuralgia, a condition causing severe facial pain. One group gets standard carbamazepine alone, another adds the antiviral acyclovir, and the third adds the anti-inflammatory celecoxib. The goal is to see which combin…

This study tests whether injecting a numbing medicine (bupivacaine) into the surgical site during sling surgery for stress urinary incontinence can reduce pelvic and thigh pain after the operation. Sixty women will be randomly assigned to receive either the numbing medicine or a …

This study tests whether pelvic floor down training—gentle breathing and relaxation exercises—can reduce tailbone pain in new mothers. Fifty-two women, 6 months to 1 year after childbirth, will practice these exercises daily. Researchers will measure pain and daily function befor…

This study will test two FDA-approved migraine drugs, rimegepant (a tablet that dissolves on the tongue) and zavegepant (a nasal spray), in 100 adults visiting the emergency department for a migraine. The goal is to see if these drugs provide pain relief within 2 hours without ne…

This pilot study tests whether injecting hyaluronic acid directly into the bladder wall is safe and can reduce pain and frequent urination in people with interstitial cystitis (bladder pain syndrome). Fifteen adults who haven't improved after standard treatments will receive the …

This study tests a self-guided digital psychology app, called Manage My Pain, along with weekly email reminders, for people with fibromyalgia or chronic pelvic pain who are on a waitlist for specialized pain care. The goal is to see if this approach is feasible and acceptable, an…

This study investigates whether a high-concentration capsaicin patch can reduce chronic neuropathic pain in the pelvic and perineal region. Researchers will measure changes in pain sensitivity before and after treatment in 30 adults with long-lasting pelvic nerve pain. The goal i…

This study tests whether neurofeedback—a type of brainwave training—can help adults with episodic migraine have fewer and less severe headaches. Participants will undergo 60 sessions over 12 weeks, learning to regulate their brain activity through real-time feedback. The goal is …

This study tests a new device called the EpiFaith™ Syringe, which gives a clear visual signal when a doctor reaches the right spot for an epidural pain injection. Currently, doctors rely on feel alone, which can lead to multiple needle sticks or mistakes. The study will compare t…

Many people with migraine also suffer from tinnitus, a persistent ringing in the ears. This trial will compare two types of migraine preventives—newer anti-CGRP drugs and older medications like antidepressants and blood pressure drugs—to see which better reduces tinnitus symptoms…

This study tests a virtual behavioral program for people with chronic migraine. Researchers want to find the best combination of techniques and see if letting patients choose their treatment helps. The goal is to reduce migraine frequency and intensity.

This study will test whether guided walks in a forest can reduce chronic pain and improve quality of life in 70 adults with fibromyalgia. Participants will take slow, sensory-focused walks in nature, while researchers measure pain levels and medication use. The goal is to see if …

This study looks at whether semi-permanent ear acupuncture can help women with fibromyalgia feel less pain and improve how their nervous system works. Thirty women aged 35 to 64 will get weekly treatments for five weeks. Researchers will measure pain sensitivity and heart rate ch…

This study tests whether eptinezumab, a drug used for migraines, can reduce the number of headache days in adults with idiopathic intracranial hypertension (IIH), a condition where high fluid pressure around the brain causes severe headaches. About 96 women aged 18-55 with chroni…

This study tests a hands-on technique called manual diaphragmatic release in 60 women with fibromyalgia who are not very active. The goal is to see if it improves exercise capacity, breathing muscle strength, symptoms, and quality of life. Participants will be randomly assigned t…

This study tests whether an 8-session self-hypnosis program, delivered online in groups, can help adults with migraines reduce disability and improve well-being. Forty participants are randomly assigned to either the hypnosis training or a waitlist. The program teaches self-hypno…

This study compares two muscle energy techniques—post-isometric relaxation and reciprocal inhibition—for treating piriformis syndrome, a condition causing buttock pain and limited movement. Researchers will enroll 42 adults aged 25-40 with confirmed piriformis syndrome and modera…

This study tests whether a newer form of spinal cord stimulation (paresthesia-free SCS) actually reduces chronic pain or if its benefits are just a placebo effect. Ninety adults with severe neuropathic pain will receive both active and placebo stimulation for six weeks each, with…

This study tests whether adding fire needling (a technique using heated needles) to standard acupuncture can better reduce headache days in people with both chronic migraine and tension-type headache. Eighty-eight adults will receive either the combined treatment or acupuncture a…

This study tests if a procedure called middle meningeal artery embolization can help people with frequent migraines. The procedure uses tiny coils to block a blood vessel in the head. Researchers want to see if it reduces migraine days and the need for migraine medications. The s…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study looks at whether anti-IL-6 drugs, used for inflammatory conditions like rheumatoid arthritis, can also reduce migraine frequency and intensity. Researchers will compare 320 people taking anti-IL-6 drugs to those on anti-TNF drugs. Participants will report how their mig…

This study tests if botulinum toxin (like Botox) provides longer-lasting pain relief than a standard numbing injection for people with chronic nerve pain after losing a limb in combat. About 100 adults with confirmed nerve pain will get one of the two injections and be tracked fo…

This study looks at two ways to inject botulinum toxin (like Botox) to treat long-term nerve pain from amputation in 100 combat veterans. The goal is to see which method—injecting inside the nerve or around it—works better for reducing pain and improving daily life. Participants …

This study compares opioid-free anesthesia to standard opioid-based anesthesia in 400 adults having elective heart surgery. The goal is to see if avoiding opioids can reduce both short-term and long-term pain, while also lowering side effects like delirium and nausea. Patients wi…

This study will test whether sensory motor training for neck muscles, combined with nerve gliding exercises, can improve hand grip strength in 50 post-menopausal women with fibromyalgia-related neck pain. Participants will do laser-guided neck movements and nerve stretches for fo…

This study tests whether injecting botulinum toxin (like Botox) into the piriformis muscle can reduce pain and improve quality of life in people with piriformis muscle syndrome. About 108 adults who have had buttock or leg pain for at least 3 months and haven't gotten relief from…

This study compares a combination of two drugs (dexamethasone and metoclopramide) against standard painkillers (paracetamol or NSAIDs) for treating severe primary headaches in the emergency department. 94 adults aged 18-60 with a pain score of 5 or higher will be randomly assigne…

This study tests a lidocaine spray (APC101) for people with postherpetic neuralgia, a painful nerve condition after shingles. The spray delivers pain relief without touching the sensitive skin. About 333 adults will use the spray or a placebo to see if it reduces pain over 24 hou…

This study tests whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve daily function in people with peripheral neuropathy who also have plantar fasciitis (heel pain). About 114 adults will receive either real or sham shockwave treatment. The goal is to see …

This study tests whether a nerve block injection at the back of the head can help people with migraine who overuse painkillers. The injection contains lidocaine and a steroid. 130 participants will receive either the active injection or a placebo. Researchers will track headache …

This study will monitor the safety and effectiveness of NURTEC ODT 75 mg (rimegepant) in 3000 Korean adults with migraine. Participants will take the drug as prescribed for acute attacks or prevention. Researchers will track side effects and how well the drug works, including pai…

This study compares two non-invasive laser treatments—high-intensity and low-level—for people with trigeminal neuralgia, a condition causing severe facial pain. About 38 adults who haven't found relief from medication or can't have surgery will receive one of the two laser therap…

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. 32 adults will use the device at home for 30 days. The main goal is to see if the treatment is practical and well-tolerated, whi…

This study tests whether a spinal cord stimulator can reduce chronic nerve pain caused by chemotherapy. 68 adults with pain lasting over a year will have the device implanted and then randomly receive either active or sham stimulation. The goal is to see if active stimulation pro…

This study tests whether a four-week physiotherapy program and a meditation app can reduce headache pain and improve quality of life in 78 adults with frequent or chronic tension-type headaches. Participants will be split into groups receiving physiotherapy, meditation, or both. …

This study tests whether a new drug called NB001 can quickly stop migraine pain and other bothersome symptoms. About 120 adults with migraines will take different doses of NB001 or a placebo at the start of an attack. Researchers will check if pain and symptoms go away within 2 h…

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. Thirty adults with shingles-related pain will receive a single application of the gel. Researchers will measure pain levels before and after application, focusing on relief with…

This study tests whether electroacupuncture can improve sleep in people with long-term sciatica caused by a slipped disc. About 114 adults with chronic insomnia and leg pain will receive either real electroacupuncture or a sham version three times a week for four weeks. Researche…

Stanford University is testing a wearable ultrasound device that targets peripheral nerves to reduce chronic pain. The device is placed on the skin over the painful area and delivers focused ultrasound waves. In this early study, 90 adults with nerve-related pain will attend a si…

This study looks at whether adding sodium bicarbonate (baking soda) to a standard lidocaine injection can provide better pain relief for people with myofascial pain syndrome, a condition causing muscle pain and trigger points. Thirty adults will be randomly assigned to receive ei…

This study tests whether osteopathic manipulation—gentle manual techniques on the neck and head—can reduce migraine pain and its impact on daily life. 45 adults with frequent migraines will receive the therapy. The goal is to see if this drug-free approach offers real relief.

This study tests three different types of tinted lenses—FL41 glasses, Biomedics55 contacts, and Altius grey-green contacts—to see which works best for reducing light sensitivity (photophobia) in people who get migraines or have other eye conditions. About 200 volunteers who have …

This study will test whether pelvic floor-focused clinical Pilates exercises can reduce pain, improve self-esteem, body image, and quality of life in women with dyspareunia (painful intercourse). Twenty sexually active women aged 18-55 will participate. The goal is to see if this…

This study compares a specialized posture-correction exercise program (Mirror Image Spine Correction) with standard physiotherapy for adults with sciatica. Over 12 weeks, 64 participants will receive supervised sessions three times per week. The main goal is to see if the new exe…

This study tests whether listening to self-selected music before, during, and after interventional pain procedures can reduce anxiety, pain catastrophising, and acute pain in adults with chronic pain. 110 participants will be randomly assigned to either music therapy or standard …

This study compares two ways of treating chronic musculoskeletal pain: one focused on reducing pain, and another focused on improving daily function. About 24 adults with long-term pain will attend weekly sessions for 3 months, including education, exercise, and goal-setting. The…

This study tests whether ketamine injections combined with psychotherapy can help people with treatment-resistant depression. Researchers will use brain scans to see if changes in brain activity link to improvements. About 25 adults will receive 1-2 doses of ketamine and several …

This study compares two common back surgeries for people with lumbar spinal stenosis (a narrowing of the spine that presses on nerves). One surgery only removes the pressing bone and tissue, while the other also adds metal screws and rods to stabilize the spine. Researchers will …

This study tests whether combining Botox injections with a nerve block at the back of the head works better than either treatment alone for chronic migraine. About 90 adults with frequent migraines will receive one of the treatments or both. The goal is to see if the combination …

This study tests whether a safe electrical stimulation device placed on the ear (taVNS) can relieve chronic pain in people with fibromyalgia. Sixty participants will use the device twice daily for four weeks. Researchers will measure changes in pain, mood, and daily function to s…

This study tests whether a stronger laser (high-intensity) works better than a standard low-level laser for reducing pain and improving jaw movement in people with chronic jaw muscle pain. Forty adults will receive 12 laser sessions over one month and be followed for six months. …

This study tests whether combining virtual reality with motor imagery exercises can reduce pain and improve quality of life in people with fibromyalgia. Twenty-eight adults with fibromyalgia will be randomly assigned to either conventional exercise alone or conventional exercise …

This study will test whether different diets—a very low-calorie ketogenic diet, a Mediterranean diet, or a Mediterranean diet with added probiotics—can reduce pain and improve quality of life in women with fibromyalgia who are overweight or mildly obese. Researchers will track pa…

This study compares two procedures—a nerve block and a pulsed radiofrequency treatment—to see which works better for people with chronic migraine. About 70 adults who have not found relief from standard treatments will take part. The goal is to reduce headache pain and improve qu…

This study tests whether a 10-week virtual mindfulness program can improve quality of life for people with endometriosis-related chronic pelvic pain. Researchers will enroll 124 adults aged 18-50 with a diagnosis of endometriosis. Participants will attend online mindfulness works…

This study compares two types of radiofrequency treatment—pulsed and conventional—for people with long-lasting tailbone pain that hasn't improved with other treatments. Ninety adults aged 18 to 80 will be randomly assigned to one of the two procedures. The goal is to see which me…

This study will test whether giving a single dose of ketamine during open-heart surgery can reduce chronic pain that often lingers for months after the operation. Researchers will compare 100 adults who receive either ketamine or a placebo during surgery, then track their pain le…

This study tests whether combining physiotherapy, structured exercise, and psychological support can reduce the burden of chronic tinnitus (ringing in the ears) in 160 adults aged 18-70. Participants will be randomly assigned to either the 8-week multimodal program or a control g…

This study compares two treatments for buttock pain caused by piriformis syndrome and related muscle pain. Researchers will use ultrasound to guide either a sugar-water injection or a dry needle into the affected area. The goal is to see which method provides better pain relief o…

This study tests whether using a smartwatch and mobile app, along with standard care, can help adults with chronic low back pain manage their symptoms better. Eighty adults will be split into two groups: one gets standard treatment alone, the other also uses a smartwatch and app …

This early-phase trial at Boston Children's Hospital will test whether adding virtual reality (VR) to standard treatments like biofeedback and cognitive behavioral therapy can help 12 adolescents with chronic dizziness. The goal is to see if VR can safely and feasibly reduce dizz…

This study tests a personalized health coaching program for veterans with chronic musculoskeletal pain. The goal is to help them develop and stick with self-care plans. Thirty veterans will participate to see if the program is feasible and acceptable.

This study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can reduce pain in people with trigeminal neuralgia, a condition causing severe facial pain. 126 participants will either get real electroacupuncture or a sham version, while continuing …

This study tests whether a 6-week virtual reality (VR) program can help adults with chronic pain learn about pain science and manage their symptoms. Fifty participants will use VR headsets for one hour each week to watch educational content and do guided exercises. The goal is to…

This study tests whether a single session of sleep hygiene education can improve sleep quality and reduce pain in 100 adults with migraine or chronic lower back pain. Participants will learn healthy sleep habits and follow them for four weeks, tracking changes through questionnai…

This study tests whether a device called Lymphatic Enhancement Technology (LET) can reduce pain and improve quality of life in women with fibromyalgia. Forty participants will receive either active or sham LET treatments once a week for four weeks. Researchers will measure change…

Chronic pain affects over 60% of people with spinal cord injuries, and standard treatments often fall short. The EmpowerSpine program is a 10-week online course that teaches pain biology, daily activity strategies, and resilience skills. This study will test 100 participants to f…

This study tests whether laser acupuncture can reduce tension headaches in girls aged 15 to 18. Participants will receive laser treatment, and researchers will measure pain levels and trigger point sensitivity. The goal is to find a non-drug way to ease headache discomfort.

This study tests whether a non-surgical radiofrequency device can improve vaginal health and sexual function in postmenopausal women. Forty women aged 40-65 will receive either active treatment or a sham procedure over six weekly sessions. The goal is to see if this approach safe…

This study looks at whether a 12-month exercise program can reduce chronic pain in postmenopausal women. The program includes walking or cycling, strength training, and gentle yoga. Researchers think that improving insulin resistance and reducing inflammation might be how exercis…

This study looks at whether adding special brain exercises to online Pilates classes can improve memory, attention, and pain in women with fibromyalgia. Thirty women will do Pilates twice a week for 8 weeks, with some also doing kinesthetic brain exercises. Researchers will measu…

This study tests a minimally invasive nerve treatment called pulsed radiofrequency (PRF) for chronic migraine in people aged 65 and older. The goal is to see if it reduces pain and headache days, and to find out which patients respond best. Researchers will also look at frailty a…

This study tests whether adding tizanidine (a muscle relaxant) to pregabalin (a standard pain drug) works better than pregabalin alone for fibromyalgia pain. About 164 adults with daily pain will be followed for 12 weeks. The goal is to see if the combination reduces pain and imp…

This study will test whether a smartphone app called Health enSuite Migraine can help people aged 18 to 50 reduce how often they get migraine headaches. The app teaches simple techniques like managing triggers, relaxing, and changing negative thoughts. About 415 Canadian adults w…

This pilot study tests a new, non-drug treatment for vestibular migraine, a condition causing repeated dizziness and headaches. Fifty adults will receive either real or sham electrical stimulation behind the ears over six sessions. The main goal is to see if the treatment is safe…

This study tests if injecting the numbing medicine lidocaine into two brain arteries can ease chronic, hard-to-treat migraines. About 80 adults with severe migraines will receive either the injection or a placebo, and researchers will track changes in headache impact over time. T…

This study tests whether a non-invasive brain stimulation device can reduce the persistent nerve pain that sometimes follows a shingles infection. Researchers will compare real stimulation to a sham (fake) procedure in 94 adults who have had pain for at least 3 months. Participan…

This study looks at whether eating less glutamate—a natural compound found in many foods—can reduce the number and severity of migraine attacks in adults. Forty participants will either follow a low-glutamate diet or continue their usual eating habits while tracking their headach…

This study will follow 120 people with chronic pain, nerve damage from chemotherapy, radiation side effects, or slow-healing wounds who are referred for ozone therapy. Researchers will track changes in quality of life, pain, and other symptoms over several months. The goal is to …

This study tests whether combining high-intensity interval training (HIIT) with a gentle brain stimulation technique called tDCS can reduce pain, fatigue, and sleep problems in women with fibromyalgia. Forty women will be assigned to HIIT plus real tDCS, HIIT plus a sham device, …

This study tests two types of pulsed radiofrequency treatments for people with severe trigeminal neuralgia, a condition causing intense facial pain. 62 adults who haven't found relief from medication will receive either a standard or a new irregular-pulse technique. The goal is t…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study tests an injectable supplement that combines B vitamins with an energy molecule (ATP) to treat painful diabetic nerve damage. Two hundred adults with diabetes and nerve pain will receive either the ATP-enhanced shot or a standard B vitamin shot for 12 weeks. Researcher…

This pilot study tests whether simply imagining doing back extension exercises can reduce pain and improve movement in 40 adults with chronic low back pain who prefer extension. Participants will lie down and mentally rehearse press-up movements guided by a script. The study meas…

This study tests whether aromatherapy foot massage can reduce neuropathic pain in people with type 2 diabetes. 78 participants will massage their feet for 10 minutes, three times a week for 4 weeks. Researchers will compare the effects of an aromatherapy oil versus a plain oil to…

This study tests whether a personalized physiotherapy program—including manual therapy, neck exercises, balance training, and pain education—can reduce pain, fatigue, and improve physical function in people with migraine. Fifty adults aged 18-55 with 2-8 migraine attacks per mont…

This study tests a headband-like device called Nettle that delivers gentle electrical stimulation to parts of the brain involved in pain. Twenty adults with chronic migraine will use it at home for 20 minutes each day over three months. The main goal is to see if people can stick…

This study tests whether doctors can safely perform ultrasound-guided pain procedures, like nerve blocks, at home for patients with chronic or cancer pain. It includes 100 adults already receiving home hospital care. The goal is to see if this approach reduces pain, cuts down on …

This study tests whether a cream containing both testosterone and estrogen works better than estrogen alone to reduce pain during sex for women with vulvodynia. About 44 adult women with moderate to severe pain will use one of the two creams daily. The goal is to find a more effe…

This study tests whether a simple breathing exercise, called inspiratory muscle training, can improve the body's stress response and reduce symptoms like pain, fatigue, and sleep problems in women with fibromyalgia. Fifty-one women will be randomly assigned to real training, a sh…

This study compares two pain-relieving drugs, lidocaine and ketamine, given through an IV, to see if they can reduce stubborn face or mouth pain. About 105 adults with pain that hasn't responded to other treatments will receive one or both drugs. The goal is to measure pain relie…

This study tests a new approach to reduce nerve pain in people with spinal cord injury. Ten participants will receive ten sessions combining mild brain stimulation (tDCS) with virtual reality walking and muscle vibration. The goal is to see if this drug-free combo can lower pain …

This study tests whether adding gentle eye muscle techniques to standard neck and jaw manual therapy can reduce pain and disability in people with migraine without aura. Eighty-four adults aged 18–65 will receive six physiotherapy sessions over eight weeks. Half will get the comb…

This pilot study will test if the Nerivio device, a wearable armband that stimulates nerves to help the brain reduce pain, can improve symptoms in 40 children aged 8-18 with Amplified Musculoskeletal Pain Syndrome (AMPS). Half the participants will use the device every other day …

This study tests if a long-lasting numbing drug (liposomal bupivacaine) injected into the scalp before surgery can reduce pain after a specific type of brain surgery called microvascular decompression. About 100 adults having this surgery will be randomly assigned to receive eith…

This study tests whether a gentle, hands-on movement technique applied to the non-painful side can reduce pain and disability in people with cervical radiculopathy (nerve pain in the neck and arm). It includes 40 adults who will receive a single session of this technique. The goa…

This study tests a one-week course of brain stimulation (called iTBS) for veterans who have both PTSD and chronic pain. Thirty veterans will receive 5-6 short sessions each day for five days, with no placebo group. Researchers will track changes in PTSD symptoms, pain, mood, and …

This early study tests whether an extended-release form of glibenclamide (glyburide), a diabetes drug, can safely reduce nerve pain in people with multiple sclerosis. Ten adults with MS and moderate-to-severe nerve pain will receive either the drug or a placebo. The main goal is …

This study compares two types of pulsed radiofrequency treatments for postherpetic neuralgia, the long-lasting nerve pain that can follow a shingles infection. One hundred adults whose pain has not responded to standard care will receive either the regular or a new 'STP' irregula…

This study will test CGRP-targeted medications in 2,000 Chinese adults with vestibular migraine, a condition causing severe vertigo and dizziness. The goal is to see if these drugs can reduce the severity and frequency of attacks, both as immediate treatment and for prevention. P…

This study tests a non-invasive device that gently stimulates the vagus nerve through the ear to see if it can reduce pain in people with fibromyalgia. Researchers will enroll 152 adults with fibromyalgia to measure changes in pain severity. The approach is portable, safe, and lo…

This study tests whether a program of pain education and physical exercise, delivered by physiotherapists in primary care, can improve quality of life for people with chronic spinal pain. 135 adults aged 18-70 with long-term back or neck pain will be split into three groups: one …

This study will follow 460 migraine patients who receive a nerve block injection in the back of the head. Researchers want to find out which patient traits—like migraine type or headache patterns—predict a good response. The goal is to help doctors choose the right treatment for …

This study will test whether using a mind-body mobile app combined with a guided, gentle movement program can help people with chronic pain. One hundred adults aged 19 to 75 with persistent pain for at least 6 months will use the app daily and follow audio-guided movement session…

This study tests whether taking butyrate and taurine supplements daily can prevent chronic pain after heart surgery. 216 adults having elective heart surgery will receive either the supplements or a placebo for three months after their operation. Researchers will track pain level…

Researchers want to know whether migraine leaves a measurable biological trace in the body. They will collect blood, saliva and tear fluid from 60 adults with episodic migraine, both during an attack and between attacks, and compare the samples with those from people who do not g…

Researchers at Marmara University are studying whether alexithymia, a trait where people struggle to identify and describe their feelings, relates to pain intensity, quality of life, anxiety, depression, and childhood trauma in adults with chronic coccydynia. Participants have ha…

Researchers want to know whether CGRP, a protein involved in migraine, also affects the vestibulo-ocular reflex, the automatic eye movement that keeps vision steady when the head turns. The trial gives 80 people at the University Hospital Zurich either a single dose of atogepant,…

Researchers at Assiut University Hospitals are studying how often adults with multiple sclerosis also get primary headaches such as migraine and tension-type headache. About 100 patients will complete a single visit that includes a neurological exam, headache history, disability …

Researchers at Lokman Hekim University are studying how migraine affects daily life and which factors track with worse disability. About 100 adults diagnosed with primary migraine complete questionnaires on headache features, sleep quality, fatigue, neck pain, and lifestyle, plus…

Researchers at the University of Minnesota are studying why chronic pain varies so much from person to person. The study enrolls 400 adults with chronic low back pain or spinal cord injury-related neuropathic pain. Participants answer brief surveys four times a day for at least t…

This study follows 800 people who are already scheduled to receive ketamine infusions for chronic pain as part of their regular care. Researchers will use surveys to track pain levels, opioid use, and overall well-being for up to 16 weeks. A comparison group includes patients who…

Researchers at Chulalongkorn University are running an online survey of about 500 transgender adults in Thailand to learn how common headaches and migraines are in this group. Participants answer questions about their headache symptoms, disability, and use of gender-affirming hor…

Researchers at Cairo University are translating the Maine-Seattle Back Questionnaire into Arabic and checking whether it works well for Arabic-speaking patients with low back pain and sciatica. About 120 adults with recent back or leg pain complete the translated survey. The team…

This observational registry follows people with complex regional pain syndrome type 1 (CRPS-1) who received neridronate infusions in a separate clinical trial. For 12 to 24 months, participants answer online surveys about their pain, sleep, medication use, procedures, and daily f…

This pilot study investigates whether thermal imaging can identify chronic pain in infants aged 3 to 9 weeks who cry excessively. Researchers will compare body and face temperature patterns with a standard behavioral pain scale and a stress hormone (cortisol) from hair samples. T…

Researchers are studying whether a quick head-turning test, called video head impulse testing, can detect subtle differences in inner ear balance function in people with vestibular migraine. The study compares 30 people with the condition to 30 healthy volunteers. Each participan…

This study will test whether wearing a magnet helmet every day can change brain inflammation linked to migraines. Ten adults with migraines will use the helmet and have brain scans before and after the treatment period. Researchers will also track migraine symptoms through questi…

This nationwide survey aims to measure how widespread chronic occupational pain is among anesthesiologists and nurse anesthetists in Thailand. The physically demanding nature of their work—long hours of standing, awkward postures, and high stress—may lead to musculoskeletal pain …

This study investigates whether adults with plaque psoriasis are more likely to have fibromyalgia and central sensitization—a condition where the nervous system becomes overly sensitive to pain—compared to healthy people. Researchers will compare 55 psoriasis patients with 55 mat…

This study aims to classify the different types of chronic pain experienced by people with multiple sclerosis (MS). Researchers will use a detailed clinical assessment to categorize pain as nociceptive, neuropathic, nociplastic, or mixed. The goal is to see if different pain type…

This study investigates whether repetitive transcranial magnetic stimulation (rTMS) can change how the brain processes neuropathic pain—pain from damaged nerves. Researchers will use brain imaging (fMRI) and electrical recordings (EEG) to see how rTMS affects brain activity in pe…

This study is looking at whether two common nerve pain medications, gabapentin and pregabalin, might change inflammation levels or heart function in people with peripheral neuropathic pain. It will follow 75 adults—25 starting gabapentin, 25 starting pregabalin, and 25 healthy co…

This study aims to create a detailed map of the sensory nerves that transmit pain signals in humans, to better understand why chronic pain develops. Researchers will use a technique called microneurography, which involves inserting a fine electrode into a nerve to record the acti…

This study examines the most common symptoms of genitourinary syndrome of menopause (GSM) in postmenopausal women and how these symptoms impact quality of life. Researchers will also look at whether using a non-hormonal topical gel called XCM INTIM for at least 8 weeks is linked …

This observational study builds a national registry in Switzerland to collect real-world data from people receiving treatment for acute or chronic pain. Researchers track pain intensity, daily function, and quality of life over time using standard questionnaires. The goal is to u…

This study looks at people with chronic pain who are trying spinal cord stimulation (SCS) as part of their normal care. Researchers track daily pain scores, satisfaction, and the timing of decisions about getting a permanent implant. The goal is to find the shortest trial period …

This study is creating and testing two new patient-reported tools to measure recurrent urinary tract infection (UTI) symptoms. One is a daily symptom diary for adults, and the other is adapted specifically for people aged 65 and older. About 200 participants with recurrent UTIs w…

This study investigates whether biomarkers in tear fluid can help diagnose migraine and monitor response to anti-CGRP therapies. Researchers will compare tear and blood samples from 400 people with migraine and healthy controls. A subgroup will be followed over time to see how bi…

This study aims to create a tool that predicts which patients are likely to have persistent pain after lumbar spine surgery, a condition known as failed back surgery syndrome. Researchers will combine routine blood tests, MRI scans, and psychological questionnaires from 150 adult…

This study follows adults with severe, treatment-resistant migraines to see if preventive treatments—like Botox injections or Eptinezumab infusions—improve not only headache frequency but also cognitive skills such as attention and memory. Researchers will assess participants' th…

This study tracks 400 adults undergoing video-assisted chest surgery (VATS) to see how many develop chronic pain three months later. Researchers will also look for factors like anxiety, depression, and pain intensity that may raise the risk. The goal is to better understand and e…

This study looks at how women with fibromyalgia experience pain, focusing on the brain's ability to control pain signals. Researchers will measure pain thresholds and responses to repeated stimuli in 82 participants. The goal is to better understand the condition, not to test a n…

This study looks at how resilience and pain sensitivity influence physical function in people with fibromyalgia compared to healthy volunteers. Researchers will measure walking distance using a 6-minute walk test and compare it to self-reported resilience scores. No treatment is …

This study adapts the Pain and Smoking Inventory (PSI) for Turkish-speaking adults who have chronic pain and smoke daily. Researchers will test whether the translated version is reliable and accurate by comparing it with other measures of pain and nicotine dependence. The goal is…

This study translates and tests a 9-question scale called BITEC, which measures what people with chronic pain expect from their treatment. Researchers will enroll 250 adults in Turkey who have had pain for at least three months. Participants fill out surveys about their pain, exp…

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study looks at whether a type of immune cell called regulatory T cells works properly in people with chronic migraine. Researchers will compare blood samples from 24 women with chronic migraine to healthy controls. The goal is to understand if problems with these cells contr…

This study follows 50 adults with migraines who have had or plan to have a procedure called middle meningeal artery embolization as part of their regular care. Researchers will look at how headache frequency, severity, medication use, and quality of life change over 12 months. Th…

This study explores whether a noninvasive technique called transcranial electrical stimulation can reduce pain and improve quality of life in people with fibromyalgia. Participants receive daily sessions of mild electrical pulses to the scalp over four weeks, targeting different …

This study will check how often people with ADHD also have fibromyalgia, and vice versa. Researchers will collect blood and urine samples from 100 adults to look for shared biological markers. The goal is to better understand why these two conditions often occur together.

This study follows 150 adults who had a traumatic arm or leg amputation to see if a stump infection increases the risk of long-term pain. Researchers will check pain levels at 3 and 6 months after surgery. The goal is to understand if preventing infections could reduce chronic pa…

This study looks at how whole-body heat therapy (hyperthermia) changes body temperature, pain sensitivity, and pain during movement in 60 people—half with chronic widespread pain (like fibromyalgia) and half healthy. Participants will receive six heat sessions over three weeks. T…

This study will test a customized online health program for Canadian women Veterans and their families. The program includes health missions, peer support, and social connection to encourage physical activity and healthy habits. Researchers will track how many people complete the…

This study looks at 180 adults getting a heart device (like a pacemaker) for the first time. Researchers will track their pain and quality of life for a year, using surveys and a pressure gauge. The goal is to build an AI system that can predict who is at risk for long-term pain,…

This study will measure how sensitive people with episodic and chronic migraine are to pressure pain, and how that relates to their headache burden and quality of life. Researchers will compare a standard pressure pain device with a new tool called Algopeg, which is like a calibr…

This observational study looks at how people with chronic pain experience pleasant touch and how often they encounter it in daily life. Researchers want to see if these experiences are linked to pain sensitivity and body awareness. About 100 adults referred to a pain clinic in Sw…

This study looks at whether people with migraine have different motor imagery abilities—like mentally picturing movements—compared to healthy people. Researchers will use questionnaires, mental timing tests, and brain scans to measure these abilities. They also want to see if the…

This study looks at whether using a stomach ultrasound before sedation can help anesthesiologists make safer decisions for chronic pain patients. These patients often take opioids or have other conditions that slow stomach emptying, raising the risk of food or liquid entering the…

This study aims to validate a questionnaire called VM-PATHI for adolescents aged 10-20 with vestibular migraine, a condition causing dizziness and other symptoms. Researchers will test whether the tool accurately measures symptom severity and meaningful improvement. About 70 part…

This study looks at why migraine and endometriosis often happen together in women. Researchers will follow 150 women over several menstrual cycles, tracking symptoms and taking blood samples. The goal is to find differences in a molecule called CGRP and hormone patterns that may …

This study tests whether green light therapy can reduce pain in people with fibromyalgia by calming brain inflammation. Researchers will use brain scans and spinal fluid tests to see how the light affects pain pathways. The trial involves 70 adults with moderate to severe pain wh…

This observational study looks at how adults with chronic pelvic pain understand their pain and cope with it, and how these factors relate to their sexual function. Researchers will ask 50 participants to fill out questionnaires about pain knowledge, coping strategies, and sexual…

This study aims to find out how often headaches happen in people with MOGAD, a rare disease that affects the brain and nerves. Researchers will look at the medical records of 25 adults and also follow them forward in time to describe headache patterns. The goal is to better under…

This study looks at whether negative pressure wound therapy (a machine that helps heal wounds) is linked to ongoing pain six months after a war injury. Researchers will follow 150 adults with severe soft tissue injuries from blasts, bullets, or burns. The goal is to find early si…

This study follows 150 adults with severe arm or leg injuries to see if developing a blood clot raises the risk of long-term pain. Participants are enrolled within 72 hours of hospital admission and monitored for six months. The goal is to understand how blood clots and pain are …

This study compares uric acid levels in 80 adolescents (12-18 years) with and without primary headaches. Researchers aim to see if there is a link between uric acid and headaches, which could help understand what causes them. Participants will provide a blood sample and have thei…

This study uses artificial intelligence to understand how sleep quality, fatigue, and emotional well-being affect the severity of fibromyalgia. Researchers will collect data from 150 adults with fibromyalgia through questionnaires. The goal is to build a model that predicts disea…

This study tests a new way of organizing care for people with long-term pain who are seeing a physical therapist. The goal is to see if a personalized care model can improve how well different healthcare providers work together. About 66 adults with chronic pain will take part, a…

This study looks at whether early ultrasound scans of burn scars can predict which patients will have persistent pain 3 to 6 months later. Researchers will measure scar thickness, blood flow, and nerve involvement in 150 adults with blast or drone-related burns. The goal is to id…

This study follows 100 adults who had a mild to moderate combat-related traumatic brain injury to see who develops long-term pain. Researchers will track pain levels, mental health, and physical factors for 6 months. The goal is to create a tool that can predict chronic pain risk…

This study will compare women with fibromyalgia to healthy women to see how their symptoms, mental health, sleep, eating habits, and stomach issues differ. Researchers will use questionnaires and surveys to gather information from 80 women. The goal is to better understand the ma…

This study watches 15 adults with severe cancer pain who are getting a procedure called cordotomy to block pain signals. Researchers will use MRI scans to check for swelling in the spinal cord right after and one month later. The goal is to see if swelling relates to how well the…

This study looks at how being sedentary versus active affects people with fibromyalgia. Researchers will compare 66 adults on body awareness, breathing strength, fear of movement, pain sensitivity, daily function, and sleep quality. The goal is to understand how inactivity may wo…

This study looks at whether virtual reality (VR) versions of two common mobility tests—the five times sit-to-stand test and the timed up and go test—are valid and reliable for women with fibromyalgia. Researchers will enroll 51 women aged 30-60 and compare VR-based results to sta…

This study will follow 120 adults with sciatica from a herniated disc who receive a standard steroid injection. Researchers want to see if the speed and pattern of pain relief in the first few days and weeks can predict whether the treatment is still working at 3 and 6 months. Pa…

This study creates a large international database to monitor how well spinal cord stimulation and similar nerve therapies work for people with chronic nerve pain. Researchers will collect real-world data from 1,000 patients across multiple countries to track safety, quality of li…

This study will translate the Pain Metacognitions Questionnaire into Turkish and check if it is a reliable tool for adults with chronic non-cancer pain. About 210 participants who have had pain for at least three months will fill out surveys once. The goal is to provide a valid w…

This study looks at how Gamma Knife radiosurgery affects brain connections in people with severe facial pain called trigeminal neuralgia. About 28 adults will get brain scans before treatment and at 1, 3, and 12 months after. The goal is to see if changes in brain wiring match pa…

This study gives people with persistent post-traumatic headache a hormone called amylin (or a placebo) to see if it triggers migraine-like headaches. The goal is to understand why headaches continue after a mild brain injury. Only 21 adults will take part, and the results may hel…

This study looks at whether pramlintide, a drug similar to the hormone amylin, can cause migraine attacks in people who get migraines without aura. Researchers will give 21 participants either pramlintide or a placebo and watch for headaches over 12 hours. The goal is to understa…

This study looks at whether using artificial intelligence (AI) can help physical therapists make better treatment choices for people with myofascial pain syndrome (a type of muscle pain). About 70 adults with chronic muscle pain will be split into two groups: one gets therapy dec…

This study looks at 45 adults with migraine and a small hole in the heart (PFO). Researchers will use brain scans and thinking tests to see if closing the hole changes brain activity, mood, and migraine symptoms over a year. The goal is to understand the link between PFO and migr…

This study will give 21 people with migraine with aura an infusion of a protein called PACAP-38, or a placebo, to see if it can trigger an aura attack. The goal is to better understand what causes migraine aura, not to test a treatment. Participants will be monitored for 12 hours…

This study looks at why some people with type 2 diabetes develop painful nerve damage while others do not. Researchers will measure how the central nervous system processes pain in 128 adults aged 18-80 who have had diabetes for at least one year. The goal is to better understand…

This study gathers information from 40 adults with long-lasting, severe pain who are already planning to use an FDA-approved spinal cord stimulator. Researchers will analyze data from the device to see how well it works and how it affects pain, sleep, mood, and daily life. The go…

This study will use a non-invasive technique called transcranial magnetic stimulation (TMS) to measure brain activity in 20 people—10 with migraine and 10 healthy controls. By comparing how the brain's motor cortex responds, researchers hope to learn more about how migraine affec…

This study tests whether a 10-15 minute educational session about the neuroscience of pain can improve memory and change how people with chronic pain sense their body. Fifty adults with pain lasting more than a year will take memory tests and draw their pain on a body chart befor…

This study looks at 700 adults with trigeminal neuralgia who had a balloon compression procedure to relieve facial pain. Researchers will use machine learning to analyze past patient data and create a model that predicts if pain will come back. The goal is to identify key factors…

This observational study from the University of Nottingham aims to find out which factors predict chronic pain after a serious limb injury. Researchers will follow 450 major trauma patients with at least one broken limb for 6 months, asking them about their pain at 3 and 6 months…

This study looks at people who had surgery for a severe facial pain condition called trigeminal neuralgia. Researchers want to know if dental treatments or other mouth stimulation after surgery can make the pain come back. About 100 participants will answer surveys about their pa…

This study will check how often fibromyalgia occurs in women with polycystic ovary syndrome (PCOS) and how pain relates to mood and insulin resistance. About 140 women aged 18-40 with PCOS and a healthy control group will answer questionnaires and have pain thresholds measured. T…

This study looks at 70 children aged 1 month to 18 years who have neurological disorders like epilepsy, migraine, or stroke. Researchers will use echocardiograms and ECGs to check for hidden heart problems. The goal is to understand if heart issues are common in these children an…

This study looks at whether a single session of intense aerobic exercise can temporarily reduce pain sensitivity in 66 young people with and without chronic pain. Participants will walk or run on a treadmill, and researchers will measure how their pain perception changes. The goa…

This study compares how well people with chronic jaw pain (TMD) and healthy volunteers can detect thin foils placed between their teeth. Researchers will test 80 participants to see if TMD reduces bite sensitivity. The goal is to better understand how jaw pain affects daily funct…