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Timing of pain relief after back injection may predict Long-Term success

NCT ID NCT07367191

Knowledge-focused Sponsor: Marmara University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will follow 120 adults with sciatica from a herniated disc who receive a standard steroid injection. Researchers want to see if the speed and pattern of pain relief in the first few days and weeks can predict whether the treatment is still working at 3 and 6 months. Participants will rate their pain before the shot, one hour after, every 72 hours for 21 days, and then at 1, 3, and 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
betamethasone and bupivacaine (steroid and anesthetic injection)
What this could lead to
If successful, this could help doctors predict which patients will benefit most from epidural steroid injections for sciatica, improving treatment decisions.
What could go wrong
This is an observational study, not a test of a new treatment. It only looks at patterns in pain relief, so it won't prove whether the injection itself works better than other options.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients aged 18 to 65 years with lumbar disc herniation-related radiculopathy who are undergoing fluoroscopy-guided transforaminal epidural steroid injection as part of routine clinical care. All participants have clinically significant radicular pain with a pre-procedural Numeric Rating Scale (NRS) score of 4 or higher and lumbar disc herniation confirmed by magnetic resonance imaging (MRI) at a segmental level consistent with clinical findings. Patients included in the study are those who have not achieved adequate symptom relief with conservative treatment modalities and are therefore referred for transforaminal epidural steroid injection by the algology clinic. Participants are prospectively followed after the procedure to evaluate temporal changes in pain intensity and their association with clinical treatment success.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 65 years * Pre-procedural Numeric Rating Scale (NRS) pain score of 4 or higher * Presence of segmental lumbar disc herniation demonstrated on magnetic resonance imaging (MRI) consistent with clinical findings * Undergoing fluoroscopy-guided transforaminal epidural steroid injection due to insufficient response to conservative treatments, as determined by the algology clinic Exclusion Criteria: * Presence of spondylolisthesis, scoliosis, or lumbar spinal stenosis accompanying lumbar disc herniation * Presence of malignancy * History of lumbar spine surgery for disc herniation * Transforaminal epidural steroid injection within the previous 6 months * Requirement for repeat epidural steroid injection during the data collection or follow-up period * Inability to be contacted for follow-up assessments by telephone

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Conditions

The condition(s) this trial relates to.

Intervertebral Disc Displacement lumbar disk disease lumbar disk herniation, susceptibility to radiculopathy sciatica

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lumbar disc herniation Lumbar radiculopathy Radicular low back pain Sciatica

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Marmara Üniversitesi Tıp Fakültesi, Istanbul, Maltepe 34854

    Istanbul, Turkey (Türkiye)

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