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Can contrast spread predict which sciatica injection works?

NCT ID NCT07813988

Symptom relief Sponsor: Benha University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 15, 2026 · Updated 3 times

Summary

Researchers compare three fluoroscopy-guided epidural steroid injection techniques for adults with leg pain from a herniated disc. Ninety-nine participants receive either a high-volume interlaminar injection, a low-volume interlaminar injection, or a transforaminal injection. The trial tests whether the pattern of contrast dye spreading in the epidural space predicts meaningful pain relief at three months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Epidural steroid injection with betamethasone and bupivacaine, given by one of three fluoroscopy-guided approaches
What this could lead to
If contrast spread predicts who responds, doctors could tailor the injection approach to each patient and avoid treatments unlikely to help.
What could go wrong
Epidural steroid injections can cause temporary soreness, headache, or, rarely, infection or nerve injury. Contrast patterns may not predict relief, and any benefit often fades within weeks to months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 99 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 65 years. * Unilateral lumbosacral radicular pain consistent with a dermatomal distribution. * Magnetic resonance imaging-confirmed lumbar disc herniation (bulge, protrusion, or extrusion) at the corresponding clinical level. * Persistent symptoms despite at least 6 weeks of conservative management, including analgesics and physiotherapy. * Baseline Numerical Rating Scale pain score of 4 or greater. * American Society of Anesthesiologists physical status I to III. * Ability to understand and complete outcome assessments. * Written informed consent provided. Exclusion Criteria: * Previous lumbar spine surgery or failed back surgery syndrome. * Red-flag signs, including foot drop, urinary incontinence, or cauda equina syndrome. * Bilateral radicular symptoms or central canal stenosis requiring surgical intervention. * Coagulopathy or ongoing anticoagulant therapy. * Local or systemic infection or hepatic dysfunction. * Known allergy to contrast medium, local anesthetics, or corticosteroids. * Pregnancy. * Severe renal impairment contraindicating contrast use. * Chronic opioid use, defined as daily opioid use for more than 3 months before enrollment. * Uncontrolled systemic disease, including unstable diabetes or severe cardiopulmonary disease. * Inability to comply with follow-up.

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Conditions

The condition(s) this trial relates to.

Intervertebral Disc Displacement lumbar disk disease radiculopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lumbar disc herniation Lumbosacral radiculopathy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Benha University Hospital

    Banhā, Qalyubia Governorate, Egypt

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