Neurological pain disorder

This study compares three oral medications used to prevent migraines: atogepant (a newer drug), topiramate, and propranolol (both older). About 1,335 adults with migraine will be randomly assigned to one of the three drugs for 12 weeks. Researchers will track headache frequency a…

This phase 3 trial is testing atogepant, a daily pill already approved for adults, to prevent episodic migraines in children aged 6 to 17. About 450 participants will receive either a low or high dose of the drug or a placebo for 12 weeks. The goal is to see if it safely reduces …

This study tests whether eptinezumab, given through a vein, can safely reduce the number of migraine days in children and teens aged 6 to 17 with episodic migraine. Participants receive either the drug or a placebo, and researchers track monthly migraine days over 12 weeks. The g…

This study tests whether the drug atogepant (Qulipta) can safely prevent chronic migraines in teenagers aged 12 to 17. About 420 teens with chronic migraine will take either atogepant or a placebo pill daily for 12 weeks. Researchers will track side effects and changes in monthly…

This phase 3 trial tests whether Xeomin (a botulinum toxin type A injection) can reduce the number of migraine days in people with chronic migraine. About 780 participants will receive either Xeomin or a placebo injected into head and neck muscles every 12 weeks for up to 55 week…

This study tests whether blocking a small artery in the brain (the middle meningeal artery) with a special glue can prevent chronic migraines. About 70 adults with hard-to-treat chronic migraine will receive the procedure. The main goal is to see if it safely reduces the number o…

This study tests an implanted device that stimulates nerves at the back of the head to prevent chronic cluster headaches. Ten adults with difficult-to-treat cluster headaches will receive the implant and use it daily for 48 weeks. Researchers will track side effects and whether t…

This study tests two different stitching techniques for closing the uterus after a planned C-section. One method includes the inner lining of the uterus in the stitch, the other leaves it out. Researchers will use ultrasound 6 to 9 months later to see which method leads to fewer …

This study tests whether rimegepant, a dissolving tablet, can prevent migraines in children and adolescents ages 6 to under 18. About 640 participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if the drug reduces the number of migraine days p…

This study tests whether eptinezumab, given as an IV infusion, can reduce the number of migraine days in adolescents aged 12 to 17 who have chronic migraine (15 or more headache days per month). Participants will receive either the drug or a placebo (salt water) and track their h…

This trial tests whether inhaling a sedative called dexmedetomidine can reduce the brain's oversensitivity that drives chronic migraine. Researchers will measure changes in pain-related biomarkers and nerve signals in people with early chronic migraine. The goal is to see if this…

This trial investigates different types of steroid injections for back, neck, and related pain to see which are most effective and safe. It compares various steroids, doses, and injection sites, including epidural and facet joint injections. The study measures pain relief and fun…

This study compares two treatments for frozen shoulder: a newer procedure called transcatheter arterial microembolization (TAME) and standard corticosteroid injections. TAME aims to reduce pain by blocking abnormal blood vessels in the shoulder, while steroids work by calming inf…

This trial tests whether a robot-assisted surgical procedure can relieve chronic pain caused by trapped nerves in the pelvic area. The surgery aims to free the pudendal and inferior cluneal nerves, which may be compressed and causing pain. Researchers will measure changes in pain…

This trial tests whether a new type of deep brain stimulation (DBS) can better relieve chronic pain that hasn't responded to other treatments. Unlike traditional DBS, which delivers constant stimulation, this approach uses a device that adapts stimulation in real time based on br…

This phase 3 trial tests whether incobotulinumtoxinA (Xeomin), a botulinum toxin that does not require refrigeration, works as well as onabotulinumtoxinA (Botox) for preventing chronic migraine. Adults with 15 or more headache days per month will receive injections of either drug…

This study tests whether taking atorvastatin (a widely used cholesterol-lowering drug) every day for 12 weeks can reduce the number of migraine days in people with chronic migraine. About 300 adults aged 18–64 with chronic migraine will receive either atorvastatin or a placebo pi…

This study tests whether daily mindfulness text messages can help people taking medication for opioid use disorder who also have chronic pain. Participants receive medication reminders and either two or four mindfulness messages per day for six weeks, along with brief surveys thr…

This small study tests an implanted device that sends mild electrical pulses to nerves in the head and neck to prevent chronic cluster headaches. Ten adults who did not get better with the drug verapamil will receive the stimulator. Researchers will check how safe it is and wheth…

This study tests whether atorvastatin, a common cholesterol medicine, can prevent migraine attacks in adults with episodic migraine (4-14 attacks per month). Researchers will compare a 20mg dose, a 40mg dose, and a placebo over several months. The goal is to see if the drug reduc…

This study tests a telemonitoring device called ANTALGEEK® that helps people manage acute pain at home after outpatient surgery. The device tracks pain levels and guides medication use, aiming to improve recovery and lower the risk of chronic pain. About 150 adults having surgery…

This pilot study explores whether taking high-dose cocoa extract supplements is feasible and acceptable for people with episodic migraine. Researchers will compare two doses of cocoa extract to a placebo, tracking how many participants stick with the daily pills for 12 weeks. The…

This study tests the long-term safety of eptinezumab (Vyepti) in 600 children and teens aged 6 to 17 with chronic or episodic migraine. Participants must have completed a prior study. The main goal is to track side effects over time, with additional measures of drug levels and im…

This study is testing whether the drug rimegepant, taken as a tablet every other day, can help prevent migraines in adults who have at least four migraine days per month. Researchers will track changes in migraine frequency over three to twelve months. The goal is to see if rimeg…

This study will follow 2,641 people with episodic or chronic migraine to see how well newer drugs—like monoclonal antibodies, gepants, ditans, and a sumatriptan-naproxen combo—work in everyday life. Researchers will track monthly migraine days, pain relief within 2 hours, and any…

This Phase 2 trial tests whether a new drug called MEDI0618 can safely reduce the number of migraine headache days in adults with episodic migraine. About 488 participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug lowe…

This study tests a new way to help people with chronic non-cancer pain who have been on long-term opioids. Instead of usual care, a team of doctors, pharmacists, physiotherapists, and psychologists works with the patient to create a personalized plan. The goal is to reduce pain i…

This study tests whether counseling plus a muscle relaxant (tizanidine) can help adults who have used opioids for a long time reduce their pain medication after elective surgery. About 375 participants will be randomly assigned to one of three groups: the combo treatment, counsel…

This study tests whether CBD oil (a non-psychoactive cannabis compound) can prevent chronic migraines. About 72 adults with frequent migraines will receive either a low dose of CBD, a higher dose, or a placebo for several months. Researchers will track changes in headache days to…

This study is for people with idiopathic intracranial hypertension (IIH) who have been on the drug acetazolamide for over a year without enough relief. It tests whether placing a small stent in a narrowed brain vein can lower the pressure and improve symptoms like headache and vi…

This study tests whether daily text reminders and mindfulness messages can help people taking medication for opioid use disorder stay on track with their treatment. About 60 adults who recently started or restarted methadone or buprenorphine will receive texts for up to 6 months …

This study follows 2,000 people with chronic pain who are implanted with Abbott neurostimulators (spinal cord or dorsal root ganglion stimulators). Researchers will track side effects, device problems, and how well the devices control pain over time. It is an observational study,…

This study tests whether repeated injections of a steroid around a nerve in the back of the head can prevent cluster headache attacks in people with chronic cluster headache. Fifty adults with at least four attacks per week will receive either the steroid or a placebo injection e…

This phase 2 trial tests whether a weekly dose of cabergoline, a drug that affects dopamine, can reduce the number of migraine days in adults with episodic migraine (4-14 migraine days per month). 150 participants will be randomly assigned to receive cabergoline (0.5 mg or 1.0 mg…

This study tests whether placing a small stent in a narrowed brain vein can reduce high pressure inside the skull and improve symptoms like vision loss, headache, and tinnitus. About 114 adults with newly diagnosed idiopathic intracranial hypertension will be randomly assigned to…

This observational study will follow 700 people with migraine who are prescribed anti-CGRP drugs (monoclonal antibodies or gepants) for prevention. Over two years, researchers will track changes in monthly headache days, migraine impact, and disability. The goal is to see how the…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial features, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) to …

This study compares two types of CT myelography scans to detect CSF-venous fistulas, abnormal connections that cause spinal fluid leaks, in 200 adults with spontaneous intracranial hypotension (low-pressure headaches). Participants will be randomly assigned to receive either a ne…

This study tests a simple 10-question scale designed to help neurologists quickly identify migraine patients who could benefit from physiotherapy. Many migraine patients have neck problems that make their headaches worse, but neurologists often lack time or training to assess thi…

This pilot study tests whether artificial intelligence can recognize pain by analyzing facial expressions in people with fibromyalgia. Researchers will compare 61 fibromyalgia patients with 61 healthy volunteers. They will also check saliva samples for biological markers of pain.…

This study is translating and testing a questionnaire called PainPREDICT for Thai-speaking people with diabetes. The goal is to create a mobile app that can screen for painful diabetic neuropathy, a common complication that causes nerve pain. Researchers will check if the Thai ve…

This Phase 2 study tests whether a daily pill called EVO756 can prevent migraines in adults who have not had success with other preventive treatments. About 330 participants will receive either EVO756 or a placebo, and researchers will track how many migraine days they have each …

This study tests whether the oral medication venlafaxine, typically used for depression, can prevent postherpetic neuralgia—a persistent nerve pain that often follows a shingles rash. Researchers will enroll 832 adults who have had a shingles rash for less than 30 days and are ex…

This phase 3 trial tests whether injections of Xeomin (a botulinum toxin type A) into head and neck muscles can prevent episodic migraines. About 990 adults with episodic migraine will receive either Xeomin or a placebo every 12 weeks for up to 55 weeks. The main goal is to see i…

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half …

This study looks at the safety and effectiveness of atogepant, a drug already approved for migraine prevention, in Korean adults. About 3000 people with chronic or episodic migraines will take the drug as prescribed by their doctor and be followed for up to 12 weeks. The goal is …

This study tests whether giving a single IV dose of lidocaine before a C-section can prevent headaches caused when doctors press on the belly to deliver the baby. About 680 women having planned C-sections under spinal anesthesia will be randomly assigned to receive lidocaine or a…

This phase 3 trial tests whether adding daily calcitonin injections to standard shingles treatment can prevent postherpetic neuralgia, a painful nerve condition that can last for months or years. Researchers will enroll 168 adults aged 50 and older who have had a shingles rash fo…

About 30% of people who have surgery for a herniated disc still suffer from nerve pain afterward. This study tests whether applying a gel made from the patient's own blood (platelet-rich fibrin) around the nerve during surgery can prevent that chronic pain. The trial will enroll …

This study tests whether a nerve block given before mastectomy can prevent depression and chronic pain afterward. Researchers will compare 140 women who receive the block to those who do not. The goal is to see if this simple procedure can improve recovery and quality of life.

This study tests a small device placed inside the nose that delivers gentle stimulation to prevent migraines. 110 adults with migraines will use the device at home every other day for six weeks. Researchers will track how many migraine days they have compared to a group that star…

Researchers are gathering feedback from Canadian Veterans with chronic pain and from clinicians who treat them. The goal is to adapt an existing digital psychology program, based on Acceptance and Commitment Therapy and delivered through the Manage My Pain app, so it better fits …

This study looks at whether adding pelvic floor physical therapy before standard radiation treatment can help reduce pain and sexual problems in women with cervical, vaginal, vulvar, uterine, or anal cancer. About 20 participants will receive education on using a vaginal dilator …

This study tests zavegepant (Zavzpret), a nasal spray already approved for migraines, in 200 adults who also take CGRP-targeting preventive medications. Researchers want to see if it provides headache relief within 2 to 4 hours and improves daily function. The goal is to find a s…

Fibromyalgia causes widespread pain, sleep problems, and fatigue. This trial tests whether a structured breathing technique called box breathing — inhaling, holding, exhaling, and pausing for 4 seconds each — can improve sleep quality, pain, and comfort. Sixty adults with fibromy…

Researchers are testing whether ketamine infusions combined with mindfulness-based cognitive therapy improve quality of life more than mindfulness therapy alone in adults who have both chronic pain and posttraumatic stress disorder. The pilot study enrolls 30 veterans and civilia…

Researchers are testing whether Reiki therapy reduces pain and the overall impact of fibromyalgia in women. Eighty-four women with a confirmed diagnosis will receive either real Reiki or a sham session with no hand placement, once a week for four weeks. The trial measures pain in…

Trigeminal neuralgia causes sudden, severe facial pain that can send people to the emergency department. This observational study at a Spanish hospital follows 20 adults who receive intravenous lacosamide, an anti-seizure drug, as a rescue treatment for a pain flare. Researchers …

This study tests whether a 7-minute guided mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for spine pain. Half of the 80 participants will do the mindfulness exercise, while the other half will receive standard pa…

This trial tests whether Yangyin Roujin Formula, a Chinese herbal blend, can reduce pain and improve quality of life in people with fibromyalgia. Sixty adults with fibromyalgia will receive either the herbal formula or a placebo for 12 weeks. Researchers will also collect blood, …

This study tests an oral medication called ubrogepant, already approved for adults, to see if it safely and effectively treats migraine attacks in children and adolescents aged 6 to 17. About 1,059 participants with a history of migraine will receive either a low or high dose of …

This study tests whether a modified version of the muscle relaxant metaxalone (640 mg) can reduce low back and leg pain in people with acute sciatica or spinal stenosis. Fifty adults aged 18 to 80 with new-onset pain will take either the drug or a placebo for 7 days. Researchers …

Researchers at Massachusetts General Hospital are testing whether non-invasive vagus nerve stimulation can reduce pain and related symptoms in people with fibromyalgia. The study enrolls 60 adults aged 18 to 80 who have had fibromyalgia for at least three months and report modera…

Researchers are testing whether electroacupuncture can prevent migraines that strike around a woman's period. The trial enrolls 40 women aged 18 to 45 who have regular cycles and at least three headache days during each menstrual window. Participants receive either real electroac…

Researchers are testing whether blocking blood vessels in the middle meningeal artery with a liquid material called SQUID can reduce the number of migraine days in people with chronic resistant migraine. The study enrolls 30 adults aged 21 to 70 who have had chronic migraine for …

This phase 3 trial tests whether the drug neridronate, given as four IV infusions over 10 days, can reduce pain and other symptoms of complex regional pain syndrome type 1 (CRPS-1). About 270 adults with CRPS in one limb will receive either the drug or a placebo. The main goal is…

This study tests a program that combines a pain education class with immersive virtual reality sessions to help older adults with chronic pain overcome their fear of movement. Participants will be randomly assigned to receive either the education alone or the education plus up to…

Researchers are testing whether Tai Chi training or acupuncture can reduce migraine attacks in Hong Kong Chinese women with episodic migraine. The trial assigns 132 participants to either 24 weeks of Tai Chi or a course of acupuncture. The team tracks migraine frequency and days,…

This study tests an internet-based therapy program for people with chronic pain who also feel anxious or depressed. About 10 adults will try a 5-week online course with phone support from a psychologist. The goal is to see if the program helps reduce pain's impact on daily life a…

Researchers are testing an internet-delivered form of acceptance and commitment therapy for people aged 15 to 24 who have PTSD and chronic pain. Participants work through online modules on trauma education, facing avoided memories and situations, mindfulness, and acceptance, with…

This study looks at whether a single session of ultrasound-guided dry needling—inserting thin needles into tight neck muscles—can safely reduce headache symptoms. About 50 adults who have had headaches in the last 6 months and have tender neck muscles will participate. The goal i…

This study tests whether a specific physical activity program, called the GH Method, can improve physical abilities in people who are frail and on dialysis or have advanced kidney disease. Participants attend two one-hour muscle therapy sessions per week for 12 months. Researcher…

This study tests a drug called N-acetyl-L-leucine for people aged 4 and older with CACNA1A gene disorders, which can cause coordination problems, dizziness, and migraines. About 60 participants will receive either the drug or a placebo, then switch, to see if it improves movement…

This trial tests whether extracorporeal shock wave therapy (ESWT), which delivers sound waves to painful areas, can ease symptoms of complex regional pain syndrome type I (CRPS-I) that sometimes follows a wrist fracture. Sixty adults with CRPS-I will receive standard rehabilitati…

This Phase 2 trial tests an experimental oral drug, LY4065967, for knee pain caused by osteoarthritis. About 150 adults with chronic knee pain and confirmed osteoarthritis will receive either the drug or a placebo. The main goal is to see if the drug safely reduces pain intensity…

This Phase 2 trial tests an oral drug called LY4065967 in 150 people with chronic low back pain lasting at least 3 months. Half will get the drug, half a placebo, to see if it safely reduces pain and improves daily function. The study is not yet recruiting.

This study tests a non-drug treatment called transcranial electrical stimulation (tES) for people who have both depression and chronic pain. 240 adults will receive one of four types of brain stimulation or a fake treatment for two weeks. Researchers will check if it reduces pain…

This Phase 3 study tests whether AXS-14 (esreboxetine) can help manage fibromyalgia symptoms like pain and fatigue. About 620 adults with fibromyalgia will take the drug or a placebo daily. The study uses a 'randomized withdrawal' design to see how long the drug's effects last.

This study tests whether a type of physical therapy called explicit sensory retraining can reduce nerve pain and improve balance in people who have chemotherapy-induced peripheral neuropathy (CIPN). Participants receive either three weekly sessions of sensory retraining for the l…

This study tests if blocking the middle meningeal arteries in the brain is safe and feasible for people with hard-to-treat chronic migraines. About 13 participants will undergo the procedure and be followed for 6 months. The goal is to reduce migraine-causing substances in the br…

This study is for people with chronic back or leg pain who are already scheduled to get a spinal cord stimulator. Researchers want to see if a new method called telefitting can find the best stimulation settings faster and more effectively. Participants will try different stimula…

This study is tracking 970 adults with chronic pain who receive an Inceptiv™ spinal cord stimulator, a device that sends mild electrical pulses to the spine to block pain signals. Researchers want to see if at least half of patients get significant pain relief and better quality …

This study is testing a new way to use an already-approved spinal cord stimulator to treat chronic, hard-to-manage back and leg pain. The device sends mild electrical pulses to the spine, and the new setting (called TVP-SCS) varies the timing of those pulses. Researchers will enr…

This trial tests whether a tool called eVIS can help people with chronic pain become more physically active during their rehabilitation. Participants in the eVIS group wear a Fitbit and use a web app to see their daily steps and pain levels, alongside their usual rehab program. T…

This study tests whether a mobile app that teaches cognitive behavioral therapy (CBT) can reduce chronic pain and improve daily functioning in adolescent survivors of childhood cancer. Researchers will compare the app to standard pain education in 228 participants (teens and thei…

This study compares taking pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will enroll 750 adults wit…

This trial tests whether a steroid injection near the spine can reduce nerve pain in people with lumbosacral radiculopathy, a condition where a herniated disc presses on a nerve root. Researchers will measure pain using a standard scale before the injection and again at 3 weeks a…

This study tests an investigational inhaled medication called ASY202 (dihydroergotamine dry powder) for treating migraine attacks in adults. Participants use a handheld inhaler to take the drug or a placebo during separate migraine episodes, and neither they nor the study team kn…

This study tests whether mindfulness therapy, added to standard care, can reduce migraine attacks and improve quality of life in people with high-frequency episodic migraine. Researchers will use EEG, MEG, and wearable devices to measure brain activity before and after treatment,…

This trial investigates whether an experimental, unapproved medical device can help relieve symptoms in people with a specific condition. Researchers are enrolling participants to test the device's effects and safety. The goal is to see if this new approach could offer a drug-fre…

This study tests whether a non-steroidal anti-inflammatory drug (diclofenac) can reduce the need for opioid painkillers after a minimally invasive elbow procedure. 92 adults with chronic elbow pain will receive either diclofenac or tramadol, with rescue medication available. The …

This study is testing a full-body suit that delivers mild electrical pulses to muscles. The goal is to see if it safely reduces spasticity, overactive reflexes, and pain in people with neurological conditions like multiple sclerosis or fibromyalgia. Fifteen adults will try both t…

This trial tests whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can reduce pain avoidance behavior in people with Complex Regional Pain Syndrome (CRPS). Participants receive either real tACS at a frequency linked to p…

This study tests a physiotherapy program that combines neck muscle exercises with a gentle nerve stimulation technique (transcutaneous vagus nerve stimulation) in 50 adults with migraine. The goal is to see if this approach can reduce pain, improve daily function, and boost quali…

This study tests whether an 8-week group music therapy program can help active duty service members manage chronic pain. Participants are randomly assigned to either the music therapy plus standard care or standard care alone. The program includes music-guided breathing, relaxati…

This pilot study tests a psychological treatment called Pain Reprocessing Therapy (PRT) for people with chronic pain lasting more than three months. PRT teaches patients to understand how the brain processes pain signals and to change their response to pain, with the goal of redu…

This phase 3 study evaluates the long-term safety of elismetrep (K-304), an oral medication taken as needed for migraine attacks. About 1,000 adults who previously took elismetrep in an earlier trial will continue using it intermittently. Researchers will track side effects over …

This study tests a remote program called Move-MORE for people with sciatica (nerve pain from the lower back into the leg). The program combines mindfulness, gentle movement, and motivational coaching to help manage pain and improve daily function. Researchers will enroll 32 adult…

This study is testing whether a weighted blanket can help veterans with chronic pain and sleep problems. 160 veterans will use either a light (3-pound) or heavy (15-pound) blanket at home for 6 weeks. Researchers will track changes in pain, sleep quality, and medication use to se…

This early-phase study tests whether MDMA-assisted therapy can reduce pain in 20 adults with fibromyalgia. Participants receive MDMA combined with psychotherapy and undergo brain scans to see how the drug affects pain and the bond between patient and therapist. The goal is to und…

This pilot trial tests whether a short course of the steroid methylprednisolone, given as a tapering dose pack over 7 days, can reduce the frequency and intensity of headaches that follow a concussion. Adults with post-concussion headaches rated at least 5 out of 10 in severity a…

This pilot study tests a mindfulness-based program called Quiet Focus, adapted for older Black adults (age 50+) who have both chronic pain and mild depression. Researchers want to see if it's feasible and acceptable, and whether it can improve quality of life and reduce pain inte…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with severe Complex Regional Pain Syndrome (CRPS). Researchers will measure pain levels, wrist movement, and daily function in 60 adults with CRPS. The goal is to s…

This study tests whether low-intensity focused ultrasound (LIFU) can temporarily change activity in a brain area called the insula, which is involved in chronic pain. Veterans with chronic back pain and widespread pain symptoms will receive either real or sham LIFU to see if it r…

This study looks at whether taking a second dose of the migraine medication rimegepant is safe and helpful for adults whose migraine pain isn't fully relieved by the first dose. About 400 people aged 18 and older with a history of migraines will take part. Researchers will track …

This study is for active-duty military members and their families who have chronic back or neck pain. It will test treatments like acupuncture, laser therapy, and shockwave therapy to see if they reduce pain and improve daily life. The goal is to find safer, non-drug options to h…

This study tests the safety and tolerability of rimegepant 75 mg ODT for acute migraine treatment in adults in India who have had an insufficient response, intolerance, or contraindication to triptans. About 60 participants take the drug as needed at the start of a migraine attac…

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This trial asks whether an intravenous dose of magnesium sulfate can relieve acute non-traumatic headaches—such as migraines, tension-type, or cluster headaches—more effectively than the standard painkiller paracetamol. Adults arriving at the emergency department with moderate to…

This study will test a treatment called rTMS, which uses magnetic pulses to stimulate parts of the brain, in 20 women with fibromyalgia. The goal is to see if stimulating the motor cortex changes brain activity and reduces pain. Researchers will use MRI scans to compare effects o…

This study tests a program called PATH-Pain in 100 older adults (60+) who have mild cognitive impairment or early Alzheimer's, along with chronic pain and depression. The program teaches problem-solving and uses memory aids like checklists and a tablet app to help manage emotions…

This study tests a new drug, elismetrep, to see if it can quickly stop migraine pain and bothersome symptoms like nausea or light sensitivity. About 1800 adults with frequent migraines will receive either the drug or a placebo. The main goal is to measure how many people are pain…

This study tests whether a text and telephone chatbot, called My AI Companion, can help veterans with chronic pain manage their condition. The chatbot is designed to support symptom tracking, encourage coping strategies, and boost engagement, without needing internet access or ex…

This study tests whether a 12-week remote Qigong program is feasible and acceptable for adults with spinal cord injury who have chronic neuropathic pain. Participants will be randomly assigned to either practice Qigong via video or complete a short daily pain survey. The goal is …

This study tests whether describing a common pain shot (epidural steroid injection) in a very positive way helps reduce leg pain more than a neutral description. Researchers will compare three groups: positive framing of the shot, neutral framing of the shot, and neutral framing …

This European study will test a new type of spinal cord stimulation device in 200 people with persistent back and leg pain after failed back surgery. The device uses a special stimulation pattern to try to reduce pain. Researchers will track pain levels and device settings to see…

This study looks at whether adding a Whole Health Coach to standard pain management teams helps veterans with chronic pain feel better and use opioids more safely. About 432 veterans will work with a coach to set personal health goals and learn self-management strategies. The mai…

This trial tests whether a mobile app that combines pain education with clinical hypnosis can reduce pain and disability in people with chronic low back pain. About 720 adults who are seeing their general practitioner for back pain will either use the app for 8 weeks or receive a…

This study tests the long-term safety of rimegepant, a migraine medication taken as a dissolving tablet, in children and adolescents aged 6 to 18. About 600 participants with a history of migraine will take the drug as needed for up to one year. The main goal is to check for side…

This study aims to develop and test two short telehealth education sessions designed for people who smoke daily and live with chronic pain. The sessions provide information on how smoking affects health and where to find cessation resources. Researchers will first refine the mate…

This trial tests whether an experimental tablet called HL-1186 can reduce the persistent nerve pain that sometimes lingers after a shingles rash heals, a condition known as postherpetic neuralgia. About 200 adults with this pain will receive either HL-1186, a placebo, or the stan…

This trial tests whether adding kinesio tape to somatosensory motor control exercises improves pain, lower-back flexibility, balance, and daily function in people with sciatica. Adults aged 35-50 with a herniated disc in the lower back and leg pain lasting 3-6 months will receive…

This trial explores whether a patient-centered group music therapy program can help adults with chronic pain. It compares the music therapy approach to a yoga program, measuring how well participants stick with the sessions and use the techniques at home. The goal is to see if th…

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This trial tests whether dry needling and low-level laser microcurrent electrical stimulation can reduce pain and inflammation in people with acute myofascial pain syndrome in the upper trapezius muscle. Participants are randomly assigned to receive one of these treatments, a com…

This study tests a wearable device worn on the ear that stimulates nearby nerves to change brain signals. The goal is to see if it can reduce chronic pain and ease symptoms of opioid withdrawal. Adults aged 18 to 65 with chronic pain who are tapering off opioid medication will re…

This study tests a device called the PRIMUS System that uses mild electrical pulses to stimulate nerves in the head and neck. It is for people with chronic or frequent migraine who have not gotten relief from at least three preventive medicines. The goal is to see if the device s…

This study tests Pain Reprocessing Therapy (PRT) for adults with ongoing knee pain after knee replacement surgery. PRT uses eight weekly video sessions to help retrain how the brain processes pain. Researchers will compare PRT to usual care in 110 participants to see which better…

This study tests whether a device that combines hot and cold therapy with gentle compression can reduce pain, swelling, and improve hand function in people with Complex Regional Pain Syndrome (CRPS) after a hand or wrist injury. Half of the participants will use this combined the…

This early-phase study at Yale will test whether a single 25mg dose of psilocybin is safe and well-tolerated in 10 veterans who smoke daily and have chronic pain. Researchers will monitor side effects and explore whether the drug can improve pain and boost motivation to quit smok…

This trial tests whether taking Ceylon cinnamon supplements for six months can reduce pain and improve blood sugar, cholesterol, and body weight in adults with painful diabetic peripheral neuropathy. Participants are randomly assigned to receive either cinnamon capsules or a plac…

This trial investigates whether SCENAR therapy, a non-invasive electrotherapy device, can improve disability, mobility, and pain in adults with chronic non-specific neck pain lasting at least three months. Participants will receive either active SCENAR sessions or a sham (inactiv…

This study tests a new drug called (2R,6R)-hydroxynorketamine (HNK) for chronic nerve pain in the arms or legs. 25 adults will receive a single infusion of HNK, ketamine, or a placebo in random order, with 5 weeks between each. Researchers will measure pain levels, sleep, and dai…

This phase 2 trial tests whether a single 25 mg dose of psilocybin, the active ingredient in 'magic mushrooms', combined with supportive therapy, can ease chronic neuropathic pain and treatment-resistant depression in adults. Sixteen participants aged 18 to 65 with both condition…

Endometriosis often causes long-lasting pelvic pain that can disrupt daily life. This trial tests whether specialized pelvic floor physical therapy, combined with a structured exercise program, can lower pain more than a placebo version of the therapy. Women aged 18 to 45 with co…

This study tests whether shining a special laser light on painful areas can reduce nerve pain caused by chemotherapy. About 70 cancer survivors with lasting nerve pain will receive either real or placebo laser treatments. The goal is to see if this safe, non-drug approach can imp…

This study is testing a trilingual smartphone app and telehealth coaching program to help Black, Chinese, and Latinx people with chronic pain find non-drug ways to feel better. About 586 adults in the San Francisco Bay Area will join, using the app and getting coaching for 12 mon…

This program provides fremanezumab, an injectable antibody that blocks a protein linked to migraine, to children aged 6 to 17 with chronic or episodic migraine. Participants must have completed a prior Teva-sponsored study. The goal is to see whether continued treatment can safel…

This trial tests whether a smartphone app called STANZA, which delivers a type of talk therapy known as acceptance and commitment therapy (ACT), can improve daily function and well-being in people with fibromyalgia. Researchers will compare three groups: those using the app plus …

This trial tests whether three types of nerve-gliding exercises — called neurodynamics — can improve hamstring strength and endurance in athletes aged 18 to 30 who play organized sports or train regularly. The exercises aim to improve nerve mobility and reduce pain, and the study…

This study tests a program called SPARK for adults aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants receive 8 nurse visits at home to help them cope with pain and improve their mood. The goal is to see if this approach reduces pain int…

This phase 3 trial tests whether an extended-release (once-daily) form of pregabalin works as well as the standard immediate-release (twice-daily) form for relieving nerve pain caused by diabetic peripheral neuropathy or postherpetic neuralgia. About 348 adults aged 18 to 75 with…

This study tests whether a high-dose version of a gentle brain-stimulation device (tDCS) can reduce pain and other symptoms in 250 people with fibromyalgia. Participants will use the device at home, either on the motor cortex or the prefrontal cortex, and researchers will compare…

This study looks at whether an intravenous lidocaine infusion can safely reduce moderate to severe headache pain in people recovering from a non-traumatic subarachnoid hemorrhage (a type of brain bleed). Twenty adult participants with favorable neurological status will receive li…

This trial tests whether a 12-week online Hatha yoga program, done at home twice a week, can reduce migraine frequency and pain when added to usual medication. The study includes 60 adults aged 18–65 with high-frequency episodic migraine (at least 1 year of history) who are on st…

This study tests whether a supplement called Normast3 can reduce nerve pain and improve nerve function in adults with diabetic polyneuropathy, a common complication of diabetes. About 40 participants will take either Normast3 or a placebo twice daily for 12 weeks, while researche…

This study tests whether a 6-week online rehabilitation program—combining pain education and exercise—works as well as in-person sessions for adults with hemophilia who have chronic joint pain. Participants are randomly assigned to either telerehabilitation or face-to-face care. …

This study compares two 8-week programs for Black adults aged 50 and older who have chronic pain and early signs of memory decline. One program combines mindfulness-based cognitive therapy with walking, using a wrist monitor to track activity. The other focuses on staying active …

This study compares two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which one better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25-65, have H…

This study tests whether a nerve block injection near the cheek can relieve severe headaches after a brain bleed (subarachnoid hemorrhage). The injection contains a numbing medicine and a steroid. The goal is to see if it reduces the need for opioid painkillers. About 195 adults …

This study tests whether a short breathing and attention training (BAT) session can improve how the brain handles pain in people with fibromyalgia and in healthy volunteers. Participants will rate painful and non-painful sensations before and after BAT or a control breathing exer…

This study compares an online program called Veteran ACT for Chronic Pain (VACT-CP) to another online pain program, Online Pain School, for veterans with chronic pain. The goal is to see which program better helps veterans improve their daily functioning, manage pain, and enhance…

This study tests whether a non-invasive device that stimulates a nerve in the ear can help people with fibromyalgia. Participants use the device for 30 minutes daily over four weeks. The goal is to see if it reduces pain, fatigue, and other symptoms by calming the body's stress r…

This study tests whether a program that addresses chronic pain can help teens with obesity stay in weight management treatment. Fifty adolescents aged 12-18 with both obesity and musculoskeletal pain will either receive the Pain and Weight Treatment (PAW) plus standard care, or p…

This study looks at whether the position of a neck muscle before dry needling changes how well the treatment works for chronic neck pain. About 80 adults with neck pain lasting over 3 months will be randomly assigned to have the muscle stretched or shortened during two needling s…

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This pilot study will test whether chiropractic care can help people with episodic migraine (4-13 migraine days per month). Sixty adults aged 18-65 will receive either personalized chiropractic care or headache health education. The main goal is to see if a larger trial is feasib…

This pilot study tests whether a structured, evidence-based physical therapy program (including education, aerobic exercise, and relaxation) works better than standard physiotherapy for adults with migraine. About 195 participants aged 18-70 with a confirmed migraine diagnosis wi…

This study looks at whether a high-dose capsaicin patch (made from chili pepper extract) can relieve long-lasting tailbone pain that hasn't responded to other treatments. Researchers will review medical records from 106 patients treated over six years to see how well the patch wo…

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible…

This study is testing a new type of spinal cord stimulator that automatically adjusts its signal based on how your nerves respond. It aims to improve pain relief and quality of life for 25 adults with long-term, hard-to-treat pain in the trunk or limbs. The device is already appr…

This study looks at whether low-intensity shock wave therapy can help women with vulvodynia, a chronic pain condition of the vulva. Researchers will review medical records from 50 women who already received four sessions of this non-invasive treatment in routine care. They want t…

This study tests whether transcranial magnetic stimulation (TMS) can reduce pain and improve thinking, mood, and physical function in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either real TMS or a sham treatment for two days. Researche…

This study tracks about 1,000 people with migraine who are taking AJOVY (fremanezumab) as part of their regular care. The goal is to see how safe the drug is over the long term, especially regarding heart problems. Researchers will also collect information on how well it works. T…

This study investigates whether drinking plasma-activated water—water treated with light and nano gold particles to create smaller water clusters—can safely improve symptoms in people with fibromyalgia, a condition causing widespread pain. Researchers will measure changes in bloo…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce pain in people with Complex Regional Pain Syndrome (CRPS). Thirty-two adults with active CRPS will receive either real or sham stimulation over several sessions. The goal is to see if this …

This study is testing whether open-label placebo pills—capsules with no active ingredients that patients know are fake—can reduce chronic pain and improve sleep in people with temporomandibular disorder (TMD). About 111 participants will be split into three groups: one gets the p…

This study tests whether dance therapy can help teens aged 12-20 with chronic pain feel better and move more freely. 160 participants will either attend weekly dance sessions for 15 weeks or receive standard care. The goal is to see if dancing reduces pain intensity and fear of m…

This study tests whether sleeping with a weighted blanket (about 10% of your body weight) can help adults with chronic pain feel better. About 44 people will use the blanket every night for 5 weeks and report changes in pain, sleep, and daily activities. The goal is to see if thi…

This study tests whether giving people with chronic pain a placebo pill—told openly that it's a placebo—can help them safely reduce their opioid painkiller use. 86 participants will either receive the placebo alongside a mind-body program or just electronic monitoring for 6 weeks…

This study tests whether a special laser (MLS class IV) can reduce chronic pain and fatigue in people with hypermobile Ehlers-Danlos syndrome (hEDS), a condition that causes loose joints and widespread pain. Twenty-five adults will receive 10 laser sessions over 5 weeks, with pai…

This study tests three types of injections for people with chronic neck and shoulder muscle pain caused by trigger points. It compares platelet-rich plasma (PRP), a mix of PRP and steroid, and steroid alone to see which works best. 150 adults aged 18-65 with a single active trigg…

This study tests whether a capsaicin 8% patch (made from chili pepper extract) can reduce chronic nerve pain in teenagers aged 12 to 17 who have had pain for over 3 months after surgery or injury. Half the teens get the real patch, the other half get a placebo dressing. Pain leve…

This study is testing a psychological treatment for chronic pain that is adapted to the culture of American Indian and Alaska Native peoples. About 30 adults with chronic pain will take part to see if the program is acceptable and helpful. The goal is to gather information for a …

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce pain and depression in people with fibromyalgia. About 36 adults with chronic pain, some also depressed, will receive either real or sham (fake) rTMS to two brain areas. Researchers will tr…

This study tests whether group-based pain management can help low-income adults with chronic pain feel better and more supported. About 360 people from safety-net clinics will join group sessions that address pain, stigma, and social isolation. The goal is to reduce pain's impact…

This early-stage study tests whether an injection of RP-008 followed by a daily varenicline pill is safe and can reduce pain for people with trigeminal neuralgia, a condition causing severe facial pain attacks. About 24 adults aged 18-80 with classic or idiopathic trigeminal neur…

This study tests whether a coaching program combined with a decision aid can help Black patients with long-term muscle and joint pain and depression use non-drug treatments like physical therapy or counseling. 304 patients will be randomly assigned to either the coaching program …

This pilot study from Mayo Clinic tests whether a virtual lifestyle behavior training program can help people with chronic migraine have fewer attacks. Sixty adults with chronic migraine for at least one year will be randomly assigned to either the lifestyle program or a sham edu…

This study tests whether a one-time high-dose intravenous ketamine infusion can reduce the number and intensity of headaches in people with chronic daily headaches. About 56 adults will receive either ketamine or a placebo (saline) and be followed for three months. The goal is to…

This study tests whether a non-invasive procedure called vestibulocortical stimulation (VCS) can reduce pain and improve quality of life in people with fibromyalgia. VCS involves gently irrigating the ear canal with temperate water using a plastic syringe. The trial will compare …

This study compares two types of nerve-stretching exercises (tensioner and slider) for people with sciatica. Eighty participants with leg pain lasting 3 to 12 months will receive one of the techniques plus standard physical therapy. Researchers will measure pain, disability, and …

This study tests a new pain self-management program designed specifically for Black adults aged 50 to 92 who have long-term muscle or joint pain (like arthritis or back pain). The program aims to reduce pain during movement and improve daily life. Researchers will compare pain le…

This study tests whether using a bright light device for one hour each morning, combined with a consistent sleep schedule, can improve symptoms of fibromyalgia—a condition causing widespread pain and fatigue. Researchers at the University of Michigan are recruiting 390 adults wit…

This study tests whether adding foot reflexology to standard physical therapy can reduce pain and improve sleep in women with fibromyalgia. Sixty women aged 18–65 will receive either standard therapy alone or standard therapy plus foot reflexology twice a week for six weeks. Rese…

This study compares a targeted nerve block injection to usual pain treatment for people with sudden sciatica in the emergency department. About 100 adults will be randomly assigned to receive either the nerve block or standard care. Researchers will measure pain levels and walkin…

This study tests whether cannabidiol (CBD), a compound from cannabis, can ease chronic pain in 468 veterans. Participants take either CBD or a placebo for 28 days and report their pain levels. The goal is to see if CBD improves pain symptoms better than a dummy pill.

This study tests whether a home-based virtual reality (VR) neurofeedback program is practical and helpful for adolescents aged 10-16 with migraine. Participants use a wearable EEG headband that reads brain activity and guides the VR experience during short sessions three times a …

This small study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce nerve pain in people with spinal cord injury. Fourteen participants will receive either real or sham stimulation for 20 minutes. Researchers will measure pain levels and heart…

This study tests whether a pharmacist-led program can help patients reduce their opioid use by about half in the weeks before knee or hip replacement surgery. 45 adults on stable, moderate-dose opioids will work with a pharmacist to create a taper plan and get weekly check-ins. T…

This study is testing two holistic, non-drug programs to help military members manage chronic musculoskeletal pain. About 608 participants will be randomly assigned to either a single-session class called Empowered Relief, a multi-session program called Move to Health, or usual c…

This study tests whether a numbing nasal spray can safely reduce severe headaches after a brain aneurysm bleed. About 20 adults in the ICU will receive the spray along with standard pain meds. Researchers will compare pain levels and opioid use before and after treatment to see i…

This study tests whether a common back operation (microdiscectomy) actually relieves sciatica leg pain better than a pretend surgery. 122 adults with a herniated disc and persistent leg pain will be randomly assigned to get either the real operation or a sham procedure. Neither t…

This study tests if a lidocaine infusion into blood vessels in the skull can reduce chronic migraine pain, frequency, and duration. It involves 40 adults aged 18-75 with severe, hard-to-treat migraines. The treatment numbs pain receptors to provide relief.

This study tests a small, FDA-cleared device that gently stimulates nerves in the ear to reduce pain and improve daily function in 240 veterans with fibromyalgia. Half will get the real device, half a sham, and researchers will track pain levels and brain activity over 24 weeks. …

This study tests an internet-based guided self-help program for adults with chronic pain. The program uses Acceptance and Commitment Therapy (ACT) to help participants accept their pain and focus on meaningful activities. Over seven weeks, participants complete weekly online modu…

This study tests a new spinal cord stimulator device for people with long-term pain in the trunk or limbs. The device uses closed-loop technology to adjust stimulation based on nerve signals. Researchers will enroll 200 participants to see if the new features improve pain control…

This study tests whether a gel containing pregabalin, applied through the skin using ultrasound (phonophoresis), combined with calf muscle stretching, can reduce nerve pain and improve walking in people with grade III knee osteoarthritis. The trial includes 35 adults aged 40-70 w…

This study tests whether a physiotherapy program that combines gentle exercise with pain education can reduce pain and improve daily life for women with endometriosis. About 62 women will take part, with half receiving the combined program and half receiving pain education alone.…

This study tests whether Gou-Teng-San (GTS), a traditional herbal medicine, can help adults with episodic migraine. About 40 participants will be randomly assigned to receive GTS or a placebo. Researchers will measure if GTS reduces the number of migraine days per month and eases…

This study tests whether a synthetic THC drug (dronabinol) can safely reduce chronic low back pain. About 75 adults with pain lasting at least 3 months will take either the drug or a placebo daily for 8 weeks. The goal is to see if the drug is safe enough for larger trials.

This study tests a 9-week online program called RAMP that teaches mind-body skills to help rural veterans manage chronic pain. Participants attend weekly group sessions with videos, skill practice, and discussions. The goal is to see if the program reduces how much pain interfere…

This study tests whether taking oral magnesium can reduce pain and other symptoms in people with fibromyalgia who haven't gotten better with standard treatments. About 86 adults aged 18-65 will be randomly assigned to receive magnesium or a placebo. The main goal is to see if mag…

This study tests whether giving calcitonin early after a spinal cord injury can lower the chance or severity of nerve pain. About 126 adults with a recent spinal injury will receive either calcitonin or a placebo. Researchers will track pain levels and side effects for up to a ye…

This study compares two online treatments for chronic pain: an 8-week cognitive behavioral therapy program (16 hours total) and a single 2-hour pain relief skills class. Researchers want to see which works better for reducing pain intensity and interference. The study will enroll…

This study looks at whether the antidepressant vortioxetine can help people who suffer from both depression and migraine. Researchers will track 31 adults over 12 weeks to see if their mood and headache symptoms improve. The goal is to find a treatment that works for both conditi…

This study compares two numbing drug recipes for a nerve block given before leg surgery. One group gets a mix of lidocaine and bupivacaine, while the other gets bupivacaine alone. Researchers want to see which combination works faster and provides better pain control after the op…

This study tests a short behavioral treatment delivered over Zoom to help adults with fibromyalgia, lupus, chronic pelvic pain, or chronic low back pain. The goal is to reduce pain, disability, and related issues like anxiety or depression. Participants will learn strategies to m…

This study tests a personalized approach to magnetic brain stimulation for people with chronic pain. Instead of a one-size-fits-all method, researchers will use each participant's brain signals to tailor the treatment. The goal is to improve pain relief and quality of life for th…

This study tests whether personalized health coaching can reduce chronic muscle and joint pain in people aged 60 and older. 268 participants will either receive four face-to-face coaching sessions focused on exercise, diet, stress, sleep, social support, and avoiding risky substa…

This study tests whether combining brain stimulation (rTMS) with virtual reality mirror therapy can reduce hard-to-treat nerve pain. 64 adults with chronic neuropathic pain that hasn't responded to drugs will receive either real or sham mirror therapy alongside rTMS. The goal is …

This study compares two exercise approaches for dead butt syndrome, a condition where the gluteal muscles become inactive, causing pain and discomfort. Forty participants will be randomly assigned to either gluteal activation exercises alone or combined with core strengthening. T…

This study tests whether physiotherapy and a special light therapy (photobiomodulation) can reduce pain in women with provoked vestibulodynia, a condition that causes pain during intercourse or tampon use. About 240 Canadian women will receive one of four treatments: light therap…

This study tests a psychosomatic program for people with fibromyalgia, a condition causing widespread pain. The program combines group talks to reframe how patients think about their symptoms, plus museum therapy. Researchers aim to see if this approach reduces distress and impro…

This pilot study tests whether Well-Being Therapy, a short psychotherapy focused on building positive mental health, can reduce disability and distress in 30 adults with chronic migraine. Participants will receive either the therapy or a control condition. The goal is to see if t…

This study tests whether combining spinal cord stimulation with a rehabilitation program can reduce chronic nerve pain in the legs and improve physical function. Ten adults aged 18-60 with nerve pain lasting over 6 months will receive the treatment bundle. The goal is to see if t…

This study tests a new type of deep brain stimulation called 'Burst-DBS' for people with long-term facial pain or pain after a stroke. Twenty adults will have electrodes placed in the thalamus (a pain-related brain area) and try both standard and burst stimulation patterns. The g…

This study tests whether eye drops made from cord blood plasma can reduce pain in people with long-term nerve-related eye pain. Twenty adults with persistent eye pain and abnormal corneal nerves will receive the drops. Researchers will measure pain levels and nerve health to see …

This study tests whether a device that gently stimulates a nerve in the ear (transcutaneous vagus nerve stimulation) can help people with chronic fatigue from fibromyalgia or long COVID get more benefit from exercise. 60 adults who still feel very tired after a standard exercise …

This study tests whether avoiding opioids during breast cancer surgery can reduce pain and side effects afterward. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard anesthesia. Researchers will measure pain leve…

This study tests three different injections—exosomes, platelet-rich plasma (PRP), and steroids—to see which best eases long-term nerve pain after shingles. 45 adults with pain lasting at least 3 months will get four treatments every two weeks. Researchers will measure pain, quali…

This study explores whether structured dog-assisted therapy can reduce pain, anxiety, and depression in people with fibromyalgia. Sixty adults with confirmed fibromyalgia will attend 10 sessions with a therapy dog and complete surveys on pain, mood, and daily function. Researcher…

This study tests a program called the Transitional Pain Service Program for adults who have chronic pain and take opioids before surgery. The program includes pain education, therapy, and a mobile app to help patients manage pain and safely reduce opioid use. Researchers will com…

This study tests whether an 8-week program of mindfulness and body awareness, held in a university museum, can reduce pain and improve quality of life for women with fibromyalgia. About 44 women will be randomly assigned to either the museum program or a control group. The goal i…

This study looks at whether adding osteopathic care (a type of hands-on therapy) to a flexible low-FODMAP diet can further reduce IBS symptoms in people with fibromyalgia. About 96 adults will receive either real or sham osteopathic sessions alongside the diet. Researchers will t…

This early-stage study tests if a single infusion of donor stem cells can reduce long-term pain from chronic pancreatitis. Researchers will enroll 48 adults with persistent pain and track changes in pain scores, opioid use, and quality of life over 6 months. The goal is to see if…

This study tests whether very short, controlled exercise sessions (called microdoses) can help women with fibromyalgia feel better. Researchers will measure changes in muscle strength, pain, and quality of life in 36 women. The goal is to find a gentle, effective exercise plan th…

This study tests whether giving Gamma Knife radiation early—within 2 years of diagnosis—can provide better pain relief for trigeminal neuralgia than waiting. About 80 adults with classic or idiopathic TN will be assigned to early treatment or standard care. Researchers will track…

This study tests whether a machine learning algorithm can predict the best way to deliver repetitive transcranial magnetic stimulation (rTMS) to reduce headaches and body pain in veterans with Gulf War Illness. 140 veterans will receive 13 active rTMS sessions over 3-4 months, an…

This study tests whether a small, home-use device that gently stimulates a nerve in the ear can help young adults (ages 18-29) manage pain and other symptoms of irritable bowel syndrome (IBS). Eighty participants will use either the active device or a sham (inactive) version twic…

This early-stage trial tests whether stem cells taken from a patient's own bone marrow can reduce pain caused by chronic pancreatitis and possibly improve pancreas function. Forty adults with long-term painful pancreatitis will receive either the stem cells or a placebo. The stud…

This study looks at how three different levels of physical activity—45, 90, or 150 minutes per week—affect arthritis symptoms like pain and mobility. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. Participant…

This study tests a new hormone-free gel for women with genitourinary syndrome of menopause (GSM), which causes vaginal dryness, pain, and other symptoms. About 80 postmenopausal women will use the gel for 8 weeks. Researchers will measure changes in quality of life using a questi…

This study tests whether a newer therapy called Pain Reprocessing Therapy (PRT) works better than standard Cognitive Behavioral Therapy (CBT) or usual care for veterans with chronic back or neck pain. About 360 veterans will be randomly assigned to one of three groups and complet…

This study compares two different exercise programs combined with dietary advice to see which better reduces symptoms in people who have both fibromyalgia and irritable bowel syndrome. Researchers will enroll 30 adults aged 30 to 65 with moderate to severe IBS and confirmed fibro…

This study tests a non-invasive brain stimulation technique called deep rTMS to see if it can reduce chronic pain from nerve damage or fibromyalgia. About 70 adults with daily pain will receive either real or fake (sham) treatment over 3 months. The goal is to measure pain relief…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can prevent headaches after a brain aneurysm procedure. About 440 adults will either get the real stimulation or a fake version. The goal is to find a safe, drug-free way to reduce pain …

This study is testing whether a single injection of botulinum toxin (similar to Botox) around major nerves can safely reduce pain in people with Complex Regional Pain Syndrome (CRPS), a chronic condition causing severe pain and disability. Twenty adults with CRPS in one arm or le…

This study tests whether a digital sleep therapy program (Sleepio) can improve quality of life and movement in 142 adults with fibromyalgia who also have trouble sleeping. Participants will use the program at home for 10 weeks and wear devices to track sleep and activity. Researc…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a nonsteroidal anti-inflammatory drug (NSAID) only before planned walks to reduce pain while avoiding long-term side effects. The program also includes proper footwear, educat…

This phase 2 trial is testing whether cannabis-based medicines—THC, CBD, or a combination—can safely reduce chronic nerve pain in Veterans. 320 participants will receive one of these treatments or a placebo for six weeks. The goal is to see if these options offer better pain reli…

This study tests whether a high-dose capsaicin patch (made from chili pepper extract) can reduce chronic tailbone pain (coccygodynia) better than a low-dose patch. About 188 adults with pain lasting over 3 months will receive either the 8% patch or a control patch applied once fo…

This study tests if freezing the nerves around the knee (cryoneurolysis) one day before total knee replacement surgery can lower pain and help patients move better afterward. About 100 adults with knee arthritis will be randomly assigned to get the freezing procedure plus surgery…

This study tests a new way to treat severe migraines by using a mild electrical current on an artery in the head. Researchers want to see if the procedure is safe and practical for people whose headaches don't get better with standard treatments. About 12 adults with chronic migr…

This study tests whether a 6-month mobile program can help 200 older adults (65+) with knee or hip arthritis pain become more active, lose weight, and feel less pain. Participants will join weekly group or individual coaching calls and track their steps. After the program, they w…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study looks at whether a surgery called RPNI can reduce nerve pain in people who have had a leg amputated. The surgery takes the cut nerve end and wraps it in a small piece of the patient's own muscle to help it heal. Researchers will follow 20 adults for 24 months to see if…

This study is testing whether a 3-month online pelvic health program can reduce pain and improve sexual wellbeing in adult women with provoked vestibulodynia, a condition causing chronic genital pain. The program includes pain education, relaxation exercises, and pelvic floor exe…

This study tests whether a smartphone app can help Black and LGBTQ+ adults with long-term chronic pain manage their symptoms and improve daily life. Participants will use the app for pain self-management and report changes in pain interference and confidence. The goal is to see i…

This study looks at whether taking ubrogepant (a migraine medication) during the earliest phase of a migraine—called the prodrome—can prevent moderate to severe headache pain. About 189 adults who already use ubrogepant will take it as usual and report their symptoms over 13 week…

This study tests whether cognitive behavioral therapy (CBT) can help veterans with serious mental illness (like schizophrenia or bipolar disorder) who also have chronic low back pain. Researchers will measure changes in pain interference, quality of life, and pain severity after …

This study tests whether a single, 2-hour group class called Empowered Relief can help reduce pain and improve recovery after elective orthopedic surgery compared to standard care. The class teaches pain education, self-regulation skills, and mindfulness. Researchers will follow …

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study tests a smartphone app called QoLibri designed to help people with chronic pain manage their symptoms and improve their quality of life. About 410 adults with moderate or worse pain lasting over 3 months will be randomly assigned to use the app right away or after a wa…

This study tests a new, faster type of brain stimulation (called AiTBS) to see if it relieves nerve pain better than the standard method. 120 adults with long-term nerve pain will receive either AiTBS or standard stimulation over 10 days. Researchers will measure pain levels and …

This study tests a brief, 4-session cognitive behavioral therapy (CBT) program for people with urologic chronic pelvic pain syndrome (UCPPS), including interstitial cystitis and chronic prostatitis. The treatment is mostly home-based with minimal therapist contact, teaching skill…

This study is testing a new, noninvasive ultrasound device to see if it can reduce pain and other symptoms in people with fibromyalgia. About 50 adults with fibromyalgia will receive 6 treatment sessions over 2 weeks. Researchers will measure pain levels and symptom impact using …

This study tests whether giving magnesium along with the standard migraine drug prochlorperazine reduces pain more than the drug alone. About 100 adults with migraines in the emergency department will receive either the combination or a placebo. Researchers will measure pain chan…

This study is testing how well and how safely the drug rimegepant works for treating migraine attacks as they happen. Researchers will follow 100 people with migraine (with or without aura, or chronic migraine) who take a 75 mg rimegepant tablet when they have an attack. The main…

This study looks at whether the migraine drug eptinezumab can stop a migraine attack while it is being given through an IV. Researchers want to know how fast the headache goes away and if other bothersome symptoms also disappear. The study will include 50 adults who have migraine…

This study tests whether a 12-week progressive resistance exercise program can reduce chronic pain in people with multiple sclerosis. 116 participants will be randomly assigned to either the exercise group or a waitlist control group. The goal is to see if exercise provides a mea…

This pilot study tests whether scrambler therapy, a device that uses mild electrical signals on the skin, can reduce nerve pain in people with corticobasal syndrome (CBS). Twenty-five adults with CBS and moderate-to-severe pain will be randomly assigned to receive either scramble…

This study tests a new method for placing spinal cord stimulators in people with chronic back pain. The device uses electrical recordings to confirm the lead is in the right spot. Twenty adults with long-term back pain will take part, and researchers will measure pain relief and …

This study looks at whether teaching older adults about how pain works, combined with supervised exercise, can reduce chronic pain and improve daily life. One hundred people aged 65 and older with pain lasting over 3 months will be split into three groups: exercise only, exercise…

This study compares a home-use brain stimulation device (tDCS) to the drug duloxetine for treating fibromyalgia in 610 women. Participants use the device daily for 4 weeks or take duloxetine, both combined with exercise and pain education. The goal is to see if tDCS works as well…

This study tests whether taking ginger root extract daily for 8 weeks can reduce pain and improve gut health in people with chronic sciatica. Researchers will measure pain levels, gut bacteria, and brain changes in 80 adults. The goal is to see if ginger affects the gut-brain con…

This study tests if a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) can help reduce widespread pain in people with lupus. Thirty adults with lupus and fibromyalgia or chronic pain will attend 8 weekly online sessions. Researchers will check if the …

This study tests whether a scalp block (a numbing injection) can reduce severe headaches in patients who have had a brain aneurysm rupture. About 22 adults in intensive care will receive either standard care plus the scalp block or standard care alone. The goal is to see if the b…

This study tests whether taking rimegepant before a known trigger (like exercise, alcohol, or stress) can prevent a migraine from developing. It involves 60 adults with migraine who have reliable triggers. Participants take the medication ahead of the trigger and report if a head…

This study is testing whether a closed-loop spinal cord stimulator can reduce pain and improve quality of life in people with nerve damage from chemotherapy. The device automatically adjusts stimulation based on nerve responses. Twenty adults with persistent pain will be followed…

This study tests whether two natural supplements—silymarin (from milk thistle) and a hesperidin/diosmin combination (from citrus)—can reduce pain and improve quality of life in people with fibromyalgia. About 90 adults with fibromyalgia will take one of the supplements or a place…

This study tests whether playing a virtual reality walking game at home can help reduce neuropathic pain in adults with chronic spinal cord injury. 250 participants with complete injuries will use a VR headset to see virtual legs walking from a first-person view. They will play t…

This study is testing a smartphone app called Digital SPA, designed with input from teens, to help adolescents aged 12–17 manage chronic pain. The app uses Acceptance and Commitment Therapy techniques to reduce pain interference and emergency room visits. About 195 teens and thei…

This study tests whether adding a non-invasive brain stimulation technique called tDCS to a structured exercise program can reduce pain and disability in adults with chronic spinal pain that hasn't improved with usual care. Forty-two participants will be randomly assigned to rece…

This study tests whether amiloride, a drug used for high blood pressure, can reduce the number of migraine aura attacks. About 40 adults with migraine with aura will take amiloride or a placebo for several weeks, then switch. The goal is to see if amiloride can prevent the visual…

This study tests if a new biodegradable heart implant can reduce migraine days better than a standard metal implant in people with a small hole in the heart (PFO). The new implant is designed to dissolve over time, potentially avoiding long-term complications like metal allergies…

This study tests whether a spinal cord stimulator can reduce long-term leg pain in people who still have pain after lumbar spine surgery. Fifty adults aged 18-70 who have not improved with other treatments will receive either active stimulation or sham (no stimulation) for 3 mont…

This study tests a personalized approach to magnetic brain stimulation for people with chronic pain. Instead of a one-size-fits-all treatment, researchers will use each person's brain signals to customize the stimulation. The goal is to improve pain relief for the 90 participants…

This small study looks at whether combining chiropractic care with group medical visits is a practical way to help adults 65 and older who have chronic neck or back pain. Ten participants will receive both chiropractic adjustments and virtual group support sessions. The goal is t…

This study tests whether using opioid-free anesthesia during mastectomy can reduce chronic pain one year after surgery. 230 breast cancer patients will be randomly assigned to receive either opioid-free or standard opioid-based anesthesia. Researchers will also look at how psycho…

This study tests if adding laser acupuncture to standard care can reduce migraine days and medication use in people with chronic migraine who don't get enough relief from drugs. About 60 adults will receive either real or sham laser acupuncture over several months. Researchers wi…

This study tests whether deep brain stimulation (DBS) can safely reduce severe, long-lasting pain after a stroke. Thirty adults with pain that hasn't improved with other treatments will have a DBS device surgically implanted. Over 10 months, researchers will compare different sti…

This study tests a 10-week program called GetActive+ that combines gentle walking with mind-body techniques to help older adults (55+) with long-term muscle or joint pain. Researchers want to see if it improves physical function, mood, and daily activity compared to usual care. T…

This pilot study tests a new program called CRISP to help young adults aged 18-29 recover from concussion and manage headaches. The program focuses on support and recovery strategies. Researchers will measure how acceptable the treatment is and track changes in headache severity …

This study aims to understand how a light-based treatment called photobiomodulation affects sexual quality of life in women with breast cancer who have menopausal symptoms like vaginal dryness and pain. About 25 women will be asked about their sexual health before and after the t…

This study tests whether taking vitamin K2 supplements daily for 6 months can reduce the number of migraine days in adults with episodic migraine. Researchers will also measure if it improves artery stiffness, which is often higher in people with migraines. 160 participants will …

This study tests whether a 6-week virtual reality exercise program can help people with fibromyalgia manage their symptoms better than standard exercise. 80 adults with fibromyalgia will be randomly assigned to either the VR exercise group or a regular exercise group. The goal is…

This study is testing three treatments one after another for people with chronic pain who are already taking long-term opioids. First, participants try a low-dose buprenorphine patch (a safer opioid) without going through withdrawal. Then, they receive a brief cognitive behaviora…

This study compares two short behavioral therapies—mindfulness (B-MORE) and cognitive-behavioral therapy (CBT)—for adults with chronic pain. Both treatments are just two hours long and offered in English or Spanish. The goal is to see if these brief programs are practical and acc…

This study tests a safe, home-use device that sends mild electrical current to the brain (tDCS) to help people with long-term pain who only got short-term relief from a similar hospital treatment. About 70 adults with chronic nerve or pain-sensitization pain will use the device 2…

This study tests whether wearing compression garments (gloves or sleeves) can reduce nerve pain in people with Complex Regional Pain Syndrome (CRPS) of the upper limbs. Sixty participants will either receive usual care plus the garment or usual care alone for three months. Pain l…

This study tests a new program called PREP-Y, designed to help adolescents aged 12-17 with chronic musculoskeletal pain become more physically active and better manage their pain. The program includes four weekly virtual sessions teaching resilience skills like motivation and cop…

This study tests whether a personalized rehabilitation program helps people with persistent spinal pain syndrome type II (failed back surgery syndrome) return to work after receiving a spinal cord stimulator. 112 participants will be randomly assigned to either the personalized p…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce chronic nerve pain in people with cancer. Sixty participants will receive both real and sham (placebo) stimulation in a crossover design, with an 8-week break in between. The goal is to see…

This study looks at a telephone-based program called SUSTAIN that helps older adults (65+) manage depression, anxiety, and chronic pain. Participants receive brief phone assessments and care management over 12 weeks. Researchers want to see what factors influence treatment succes…

This study tests whether low doses of psilocybin, the active ingredient in magic mushrooms, can reduce pain in people with fibromyalgia. Thirty-five adults will receive a placebo and two different low doses on separate days. Researchers will measure pain tolerance and self-report…

This pilot study tests a procedure called cryoneurolysis, which uses a tiny freezing tool to temporarily numb the nerves around broken ribs. The goal is to see if it's practical to run a larger study comparing this technique plus standard pain care to standard care alone. Twenty-…

This study compares two hands-on techniques—SNAG (a gentle spinal glide) and sciatic nerve mobilization exercises—for easing non-specific sciatica pain. Thirty adults with pain lasting over 12 weeks will try both methods in a crossover design, with each session separated by 10 da…

This study tests whether adding shiatsu—a gentle Japanese bodywork therapy—to standard medical care can improve quality of life for children aged 10 to 18 with chronic non-inflammatory pain. About 40 participants will receive one 30-minute shiatsu session per week for six weeks a…

This study tests whether adding ozone therapy to standard care can reduce nerve pain caused by chemotherapy. 42 adults with cancer and persistent nerve pain will receive either ozone or oxygen gas via rectal insufflation for 16 weeks. The main goal is to see if pain and quality o…

This study follows 105 adults with chronic pain, nerve damage, or slow wound healing from cancer treatments. They receive ozone therapy as an add-on to their usual care. Researchers track changes in quality of life, anxiety, and depression to see if ozone therapy helps.

Fibromyalgia causes widespread pain, fatigue, and trouble with daily activities, and these symptoms can shift from day to day even when their average level stays the same. Researchers at Mardin Artuklu University are studying 150 adults with fibromyalgia to see whether daily chan…

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Researchers will use non-invasive brain stimulation and computer tasks to record brain signals.…

This study is testing how well a culturally adapted screening and brief counseling program works for American Indian and Alaska Native adults who have chronic pain or misuse opioids. Researchers will work with three clinics to see if the program is easy to use and helpful. The go…

This study tests whether a special band-aid (called the A-Band) and a smartwatch can measure pain in women with chronic pain using AI. About 115 women with chronic pain and healthy women will wear the devices for a week and report their pain levels. The goal is to see if the devi…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…

This study uses a technique called Quantitative Sensory Testing (QST) to understand different pain patterns in people with chronic pancreatitis. By mapping how the nervous system processes pain, researchers hope to predict which patients will benefit from specific treatments like…

This study looks at whether a special pain test called Pancreatic Quantitative Sensory Testing (P-QST) can predict how well people with chronic pancreatitis will respond to treatments like endoscopy or surgery. About 150 adults with chronic pancreatitis and ongoing pain will take…

This study evaluates a questionnaire called the Emotional Allodynia Questionnaire (AEQ), which measures how people with fibromyalgia react emotionally to everyday social cues. Researchers want to see if the tool can reliably identify fibromyalgia and tell it apart from other type…

This study looks at whether people with HIV have chronic pain because their bodies don't make enough natural painkillers (opioid peptides). Researchers will test pain sensitivity in 200 adults (with and without HIV) using heat, touch, and pressure. The goal is to understand the c…

Researchers at six Italian headache centers are following about 800 adults with trigeminal autonomic cephalalgias, a group of rare headaches that includes cluster headache, paroxysmal hemicrania, SUNCT, SUNA, and hemicrania continua. The study observes routine care rather than as…

This study looks at whether forward head posture (a common issue) is linked to worse fibromyalgia symptoms. Researchers will measure the angle of the neck in 134 adults with fibromyalgia and compare it to their symptom severity using a questionnaire. The goal is to better underst…

This study will look at the medical records of 15,000 people with chronic pain to see how well different treatments, like spinal cord stimulation, worked for them. The goal is to learn which approaches provide the best pain relief. No new treatments are being tested; instead, res…

This study uses an online questionnaire to gather information from 15,000 Spanish-speaking adults about their sexual health, behaviors, and any experiences of altered consciousness during orgasm. The goal is to better understand the range of sexual function and pleasure, and to e…

This study gives a natural brain chemical called adrenomedullin to 26 people with migraines to see if it triggers an attack. Participants first receive a migraine-preventing drug (erenumab) to block related receptors. The goal is to understand how migraines start, not to test a n…

This trial tests whether two types of upper neck therapy — a quick thrust or a gentle hold — can immediately change the size and shape of a tiny neck muscle linked to headaches. Researchers will use ultrasound to measure the muscle in 80 adults with head or neck pain. The goal is…

This study looks at whether a type of IV line called a midline catheter can be used safely and effectively for repeated lidocaine infusions in an outpatient clinic. About 500 adults with chronic pain will receive ten lidocaine infusions through a midline catheter. Researchers wil…

This study investigates how spinal cord stimulation, a device implanted to treat chronic back, leg, neck, or arm pain, affects the nervous system. Adults with a stable implant will have their device turned on or off for two-week intervals, and some will undergo brain imaging. The…

This study looks at whether certain biological signs—like genetic markers, blood chemicals, and heart rate patterns—can predict who will recover well from a wrist fracture and who might develop chronic pain or a condition called Complex Regional Pain Syndrome. Researchers will al…

This observational study aims to understand why some people with rheumatoid arthritis (RA) continue to experience chronic pain even when their inflammation is well-controlled. Researchers will compare two groups of RA patients—those with active disease and those in remission with…

This study follows 436 women undergoing hysterectomy for non-cancerous reasons to see if certain pre-surgery assessments can predict who will develop chronic pain lasting months after the operation. Researchers measure pain sensitivity using a pressure device on the shoulders, an…

This study looks at whether a condition called alexithymia—difficulty recognizing and describing emotions—affects pain levels and quality of life in people with chronic pain who use a spinal cord stimulator. Researchers will ask 20 participants to fill out questionnaires about em…

This study investigates whether people with chronic tailbone pain (lasting 3 months or more) also have alexithymia — a condition where it's hard to identify and describe emotions. Researchers will use questionnaires to measure alexithymia, pain intensity, mood, childhood trauma, …

This study looks at how much of the migraine drug galcanezumab (Emgality) appears in breastmilk after a mother receives her usual injections. Researchers will measure drug levels in milk samples from 30 women with migraine who are breastfeeding, and also track infant growth, deve…

This study is building a large online registry of US adults who experience sinus, ear, dizziness, and headache symptoms, with or without a migraine diagnosis. Participants answer questions about their symptoms, how these affect daily life, and which treatments they have tried. Th…

This study looks at how the brain naturally reduces pain signals and whether that ability affects how well a lumbar medial branch block (a common injection for back pain) works. Researchers will test 40 adults with chronic low back pain using heat, pressure, and other sensations …

This study is testing whether a non-invasive eye scan called optical coherence tomography (OCT) can help track neurological diseases like multiple sclerosis, Alzheimer's, Parkinson's, and migraine. Over two years, researchers will measure the thickness of retinal layers in 840 pa…

This study investigates what brain and sensory changes happen before and after migraine starts in adolescents aged 10-13. Researchers will use MRI scans and apply mild heat or cold to see how the brain processes pain. The goal is to find factors that predict who will develop migr…

This study investigates why psilocybin may reduce headache burden after just a few doses. Researchers will measure brain connectivity, synaptic density, inflammation markers, and sleep patterns in migraine patients and healthy volunteers before and after a single dose of psilocyb…

This study investigates why endometriosis and migraine often occur together. Researchers will measure pain sensitivity and sex hormone levels in four groups: people with endometriosis, people with migraine, people with both conditions, and healthy controls. Participants complete …

This study investigates how a person's racial background and socioeconomic status—such as income, education, and employment—affect their experience of chronic low back pain. Researchers will compare pain severity, sensitivity, and psychological factors like depression and stress …

This study tests a mobile app called Navio that helps people with chronic pain track their pain levels, mood, and medication use twice daily. Researchers want to see if the app can reveal patterns that improve pain management. The study involves about 100 adults with chronic pain…

This study is collecting information from 10,000 people aged 12 and older with common headache disorders like migraine and tension-type headaches. Researchers will track their symptoms, brain scans, genetics, and thinking abilities over time. The goal is to better understand thes…

This study examines whether three specific signs seen on CT scans — nerve-root swelling, tissue infiltration around the nerve, and increased density of the nerve — can identify the exact nerve root causing sciatica. Researchers reviewed planning CT scans from 400 adults with low-…

This study investigates the sequence of early warning signs, called premonitory symptoms, that occur before a migraine headache starts. Researchers will follow 500 adults with migraine who will record their symptoms using an electronic diary for up to five attacks. The goal is to…

This study is looking for ways to predict which migraine patients will respond well to a class of drugs called anti-CGRP monoclonal antibodies. Researchers will analyze clinical, biological, and brain imaging data from 350 adults with frequent migraines. The goal is to find bioma…

This study explores whether migraine attacks can be predicted before the headache phase begins. Researchers will monitor people with episodic migraine (10–14 migraine days per month) using a wearable device that tracks heart rate and other body signals, along with a diary of earl…

This study will check if certain blood markers can predict how well a nerve block procedure works for people with nerve pain. Researchers will measure pain levels and blood inflammation markers before and after the procedure in 120 adults. The goal is to see if these blood tests …

This study uses MRI scans to look at brain and spinal cord structure and function in people with cerebral palsy who experience chronic pain. Researchers hope to find patterns in the brain that are linked to pain and sensory issues. Participants aged 8 and older with cerebral pals…

This study looks at how the location of brain-stimulating electrodes affects pain relief in adults with long-term nerve pain that hasn't improved with other treatments. Researchers will use brain scans to see which areas are activated and how that relates to pain reduction. The g…

This study follows 250 people who had ankle fractures to see how many develop nerve-related chronic pain after the bone heals. Participants answer pain questionnaires and undergo simple sensory tests. The goal is to better understand this type of pain, not to test any new treatme…

This study follows 50 children who had a nerve-freezing procedure (cryoneurolysis) before surgery to correct a sunken chest (pectus excavatum). Researchers check for long-term nerve pain, quality of life, and sensory recovery using questionnaires. The goal is to see if the pain r…

This study looks at whether people with migraine have different shoulder muscle activity and arm performance compared to those without migraine. Researchers will measure muscle signals and shoulder movement in 50 adults aged 18-55. The goal is to understand how migraine might aff…

This study asks 200 adults with chronic pain about their preferences between pain relief and common side effects like drowsiness, nausea, or addiction risk. Participants rate how much each side effect bothers them compared to the benefit of pain relief. The goal is to help doctor…

This study looks at how emotional intelligence—the ability to understand and manage emotions—relates to chronic orofacial pain (pain in the face or mouth lasting over three months). Researchers will compare 88 adults with and without this pain using questionnaires about emotions,…

This study aims to find out if chronic pelvic pain conditions like prostatitis and interstitial cystitis can be inherited. Researchers will collect DNA and urine from 500 participants, including family members, to look for genetic links. The goal is to better understand the cause…

This study looks at whether women with Ehlers-Danlos syndrome (EDS) experience more severe period pain than those without the condition. Researchers will compare pain levels and other gynecological issues in 156 women using an online questionnaire. The goal is to better understan…

This study uses brain scans (fMRI) and sensory tests to explore how different types of chronic pain affect the brains of children and teens aged 10-17. Researchers hope to find shared and unique brain patterns across conditions like migraines, fibromyalgia, and abdominal pain. Th…

This study looks at how spinal cord stimulation (SCS) affects brain activity in veterans with long-term nerve pain. Researchers will use non-invasive brain scans (fNIRS and EEG) to compare brain connectivity in SCS users and those being evaluated for SCS. The goal is to understan…

This study looks at how inhaled cannabis affects the brain in people with chronic low back pain. Researchers will use MRI scans to measure changes in brain blood flow and oxygen levels, and ask participants to rate their pain. The goal is to understand the brain mechanisms behind…

This study looks at why some people with chronic migraine don't get better with standard treatments. Researchers want to see if a person's level of suggestibility—how easily they respond to suggestions or expectations—might help predict who could benefit from placebo effects. The…

This study looks at how long-term opioid therapy changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain and/or opioid use to healthy women. The goal is to find new ways to treat chronic pain without relyi…

This study compares two widely used drug classes—anti-convulsants and anti-depressants—for treating chronic pain in 450 real-world patients. Unlike typical trials that exclude many patients, this one includes people with other health issues to get results that apply to more peopl…

This study looks at 600 teens and young adults (ages 14-26) with conditions like juvenile arthritis, fibromyalgia, or past surgeries to understand why some develop long-lasting pain while others don't. Researchers will examine pain sensitivity, immune markers, and social factors …

This study explores how dopamine, a brain chemical linked to motivation, influences chronic pain. Ten adults with chronic pain will receive two dopamine-boosting drugs (methylphenidate and carbidopa-levodopa) or a placebo, then undergo brain scans to measure changes in key pain-r…

This study looks at how sleep problems and stress can trigger migraines in adults. Participants wear a WHOOP band to track sleep and body signals, and answer daily questions via a smartphone app. The goal is to find personal patterns and give tailored advice to reduce migraine at…

This study follows pregnant women with migraine who took rimegepant (Nurtec) and those who did not, to compare rates of birth defects and other pregnancy complications. About 780 participants will be tracked through 12 months after birth. The goal is to gather safety data, not to…

This study looks at two proteins in the blood—S100B and BDNF—to see if they are linked to pain sensitivity and poor sleep in people with fibromyalgia. Researchers will compare 60 women with fibromyalgia to healthy women. The goal is to better understand what causes fibromyalgia s…

This online registry is studying the safety and effectiveness of the CEFALY device, a non-invasive nerve stimulator worn on the forehead, for treating migraines during and after pregnancy. Pregnant women aged 18-44 with migraines can join, regardless of whether they use the devic…

This study aims to uncover genetic and biological differences between people with Menière's disease, those with vestibular migraine, and healthy individuals. Researchers will analyze blood samples from 250 participants to look for specific gene variations and biohumoral factors. …

This pilot study looks at how lowering doses of pain medications like opioids and gabapentinoids changes the way the spinal cord responds to closed-loop spinal cord stimulation. Twenty adults with failed back surgery syndrome will be followed during a 21-day trial and up to 6 mon…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study aims to create a large e-cohort of 5,000 chronic pain patients using a smartphone app called eDOL. The app lets patients report their pain, treatments, and daily life, while doctors can monitor them through a web platform. The goal is to better understand chronic pain …

This study will enroll 200 adults who have ongoing low back pain for at least 3 months after back surgery. Researchers will classify each person's pain as nerve-related, muscle/joint-related, or other, and then compare how these pain types affect pain severity, disability, and qu…

This study watches how daily emotional stress impacts memory and thinking in adults aged 60 and older living in Seoul, Korea. Participants use a smartphone app to report their feelings and do quick brain games, wear a smartwatch, and give blood samples. Researchers will check in …

This study follows 20,000 adolescents aged 12-17 who receive opioids after major surgery. Researchers track pain, opioid use, and other factors for one year to identify early warning signs of opioid use disorder. Participants complete surveys and allow access to their medical rec…

This study looks at why over 20% of migraine patients don't respond well to triptans, a common migraine medication. Researchers will compare tryptophan and related substances in the blood of 144 people who either respond or don't respond to triptans. The goal is to understand the…

This study looks at children and teens who had a limb removed before age 15-16 to see if they experience nerve pain (phantom limb or stump pain). Researchers will review medical records and use questionnaires during regular check-ups. The goal is to better understand how common t…

This observational study is gathering data from 150 adults with muscle or joint pain to see how their answers on a pain questionnaire (PainDETECT) relate to where it hurts and their official diagnosis. Researchers hope to better understand when nerve pain is involved in common mu…

This study is observing 120 people with chronic pain to learn how to design a more effective pain clinic. Researchers will track pain levels, medication use, and overall well-being. The goal is to understand what patients need, not to test a new treatment.

This study is gathering information from 1,500 people with cluster headache or trigeminal neuralgia to learn more about these painful conditions. Researchers will collect surveys, genetic samples, and other health data. The goal is to better understand what causes these headaches…

This study looks at 1,000 women to see how ultrasound features of adenomyosis (a condition where the uterine lining grows into the muscle wall) match up with their symptoms like pain and heavy bleeding. Participants get one routine ultrasound and fill out a symptom questionnaire.…

This study tests a training program called the Pain Identification and Communication Toolkit (PICT) for family caregivers of people with Alzheimer's disease or related dementias. The program teaches caregivers how to spot signs of pain and talk about it with doctors. Researchers …

This study looks at how migraine affects thinking, memory, and emotions in 150 adults. Researchers will test cognitive skills and link them to mood, anxiety, and headache patterns. The goal is to better understand the full impact of migraine on daily life.

This study is investigating why some people with migraine with aura also have a small hole in the heart called a PFO. Researchers will compare genetic differences and blood flow patterns between 240 adults who have migraine with aura, some with a PFO and some without. No new trea…

This observational study looks at why some people with knee osteoarthritis have worse pain than others, even when their knee damage looks similar on X-rays. Researchers will study 300 adults aged 45-80 with chronic knee pain. Participants will complete surveys, physical tests, kn…

This study aims to understand what causes Visual Snow Syndrome (VSS), a condition where people see constant flickering dots across their vision. Researchers will use brain scans and visual tests to find which brain pathways are involved. About 100 adults with VSS, migraine, or he…

This study looks at two types of spinal cord stimulation for people with long-term nerve pain after back surgery. One type causes a tingling sensation, while newer types do not. Researchers will use brain scans and pain questionnaires to figure out how each type works and which p…

This study is testing whether conversational AI software can effectively collect health information from people with chronic pain. Participants will chat with a digital tool that asks about their physical symptoms, emotions, and social life. The goal is to see if patients find th…

This study looks at whether taking prescription opioids for chronic pain changes the brain structure of adults aged 65 and older. Researchers will use MRI scans to measure brain changes over time. The goal is to understand the risks of long-term opioid use on brain health.

This study looks at why people with long-term nerve pain often feel less motivated. Researchers will use brain scans (fMRI) and a reward-learning task to compare 50 chronic pain patients with healthy volunteers. The goal is to understand brain changes linked to motivation, not to…

This study is creating a data bank to better understand vaginal conditions like vulvodynia, yeast infections, bacterial vaginosis, and preterm labor. Researchers will look at proteins, immune markers, and vaginal bacteria in 550 women, including healthy volunteers and those with …

This study looks at how chronic knee pain and fibromyalgia change the way nerves talk to muscles. Researchers will test pain sensitivity, muscle activity, and physical function in 135 adults. No treatment is given—the goal is to better understand the role of the central nervous s…

This observational study tracks the safety of Ubrelvy and Qulipta, two migraine drugs, when used during pregnancy. Researchers will follow about 1,884 pregnant women with migraine in the US and Canada, comparing those who take either drug to a group who does not. The goal is to s…

This study aims to create a large database and sample bank to better understand headaches. Researchers will collect health information and treatment records from 50,000 people with headaches. The goal is to develop a system that helps doctors diagnose and treat headaches more pre…

This study is testing a new tool called CANoPy that predicts whether a cancer patient will develop long-term nerve pain. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer as they undergo treatments like chemotherapy or surgery. By collectin…

This study looks at how thinking skills, personality, and pain sensitivity affect headache treatment in 64 adults with chronic or episodic headaches. Researchers will track participants for about six months to understand what helps or hinders treatment success. The goal is to fin…

This study follows 800 adults who spent at least 48 hours in the ICU to understand why some develop chronic pain. Researchers will call participants at 90 and 180 days after discharge to ask about pain, sleep, and quality of life. A smaller group will also have a detailed physica…

This study uses a special thermal camera to take pictures of the feet of people with complex regional pain syndrome (CRPS) before and after they receive spinal cord stimulation. The goal is to see if the stimulation changes blood flow and temperature in the painful limb. Research…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study looks at how quitting smoking temporarily increases pain in people with chronic pain, and how the brain processes this. Researchers will use brain scans and daily reports from 132 smokers—some with chronic back pain, some without—to understand these changes. The goal i…

This study looks at whether keeping a regular sleep schedule can improve heart and metabolic health in healthy adults aged 18-40, and also in people with chronic pain. Over 12 weeks, researchers will measure changes in sleep timing, blood pressure, heart rate, and other health ma…

This study looks at how mood, brain inflammation, and exercise are linked to pain in 60 veterans with fibromyalgia. Participants will do a 6-week supervised walking program and complete pain, mood, and blood tests. The goal is to understand these connections and design a better e…

This study follows 5,000 children aged 0-16 before and up to one year after surgery to learn how many develop chronic pain and why. Parents and children fill out questionnaires about pain, anxiety, and recovery. The goal is to find risk factors so doctors can better prevent long-…

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study is testing whether a supplement called Boswellia serrata (also known as frankincense) can change how healthy people feel pain. Twelve volunteers will take either the supplement or a placebo for a short time, then have a small amount of capsaicin (the stuff that makes c…

This study looks at how chronic pain affects sleep in teenagers aged 15-17. Researchers will test whether listening to a relaxing story before falling asleep can improve sleep quality and help process emotions related to pain. Twenty teens with persistent pain will have their sle…

This study aims to find out how common small fiber neuropathy is in people with fibromyalgia compared to those with other chronic pain conditions and healthy volunteers. Researchers will use skin biopsies and other tests to check for nerve damage. The goal is to better understand…

This large observational study will follow over 2,000 adults with migraine in Italy for two years. Researchers will collect data on symptoms, treatments, and healthcare use to better understand how migraine evolves and how patients are managed. The goal is to improve diagnosis an…

This study looks at nerve-related problems like numbness, tingling, and pain in people who have been treated for oral cavity or throat cancer. Researchers will use simple tools like brushes and temperature tests to map these sensations. The goal is to better understand how common…