Nerve block may ease headaches after brain bleed, reduce opioid use
NCT ID NCT06008795
First seen Nov 28, 2025 · Last updated Jun 20, 2026 · Updated 25 times
Summary
This study tests whether a nerve block injection near the cheek can relieve severe headaches after a brain bleed (subarachnoid hemorrhage). The injection contains a numbing medicine and a steroid. The goal is to see if it reduces the need for opioid painkillers. About 195 adults who recently had a brain bleed will be randomly assigned to get the real injection or a placebo (salt water). The study is double-blind, meaning neither patients nor doctors know who gets which treatment.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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Albany Medical College
RECRUITINGAlbany, New York, 12208, United States
Contact
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55009, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Oregon Health and Sciences University
RECRUITINGPortland, Oregon, 97239, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Thomas Jefferson University
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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University of Cincinnati
RECRUITINGCincinnati, Ohio, 45267, United States
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University of Florida
RECRUITINGGainesville, Florida, 32610, United States
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University of Maryland Baltimore
RECRUITINGBaltimore, Maryland, 21201, United States
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University of Rochester Medical College
RECRUITINGRochester, New York, 14642, United States
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University of Washington
RECRUITINGSeattle, Washington, 98104, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ropivacaine and dexamethasone
What this could lead to
If it works, this could offer a non-opioid way to manage severe headaches after a brain bleed, reducing reliance on painkillers.
What could go wrong
This is an early phase 2 trial, so it's not yet proven. The nerve block may not work better than placebo, and there are risks like bleeding or infection from the injection.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.