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Neck injection may stop Post-Mastectomy depression

NCT ID NCT06263907

Prevention Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a nerve block given before mastectomy can prevent depression and chronic pain afterward. Researchers will compare 140 women who receive the block to those who do not. The goal is to see if this simple procedure can improve recovery and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
stellate ganglion block (a nerve block injection in the neck)
What this could lead to
If it works, this could give doctors a simple way to prevent depression and chronic pain after mastectomy.
What could go wrong
This is a small, early-stage trial with no phase. The nerve block carries risks like allergic reaction or nerve damage, and the results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2024

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients * Age ranging from 18 to 65 years * American Society of Anesthesiologists (ASA) no more than II * Had unilateral cancer breast * Scheduled to do unilateral modified radical mastectomy Exclusion Criteria: * Pregnant female * Existing Horner syndrome * Had any neuromuscular disease * Had allergy to local anesthetics * History of use of analgesics * Had any deformity or a previous surgery in the neck or ipsilateral arm or breast * Had any contraindication to the procedure (coagulation disorders, local infection, sepsis) * Had any contraindication to the sympathetic blockade (decompensate cardiopulmonary or hemodynamic disorders) * History of psychotic disorder including depression, bipolar disorder or personality disorder * Patient with Beck Depression Inventory (BDI) score more than 13

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Conditions

The condition(s) this trial relates to.

Acute Pain breast cancer Chronic Pain chronic pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mastectomy Pain, acute Pain, chronic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Maha

    RECRUITING

    Al Mansurah, Egypt

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