Magnetic pulses to the brain aim to quiet CRPS pain
NCT ID NCT03137472
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether transcranial magnetic stimulation (TMS) can reduce pain and improve thinking, mood, and physical function in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either real TMS or a sham treatment for two days. Researchers will track how long any pain relief lasts and whether symptoms return to baseline.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Transcranial magnetic stimulation (TMS) device
- What this could lead to
- If it works, this could offer a non-drug way to temporarily ease CRPS pain and related symptoms.
- What could go wrong
- This is a very small, early-phase trial with only 40 participants and just two days of treatment. The pain relief may be short-lived or no better than a sham procedure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2017
- Expected to finish
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Jun 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18-70 * Diagnosis of CRPS (complex regional pain syndrome) for at least 3 months * Average pain level reported on Numerical Rating Scale meets entry criteria * Ability to perform the experimental task and procedures. Exclusion Criteria: * MRI contraindication (metal implants or devices, claustrophobia) * TMS Contraindication (eg metal implant or devices near the site of stimulation) * History of epilepsy * History of a psychological or psychiatric disorder that would interfere with study procedures, at the discretion of the researcher. * Neurologic illness that would interfere with brain integrity * Current medical condition or medication use that would interfere with study procedures or data integrity, at the discretion of the researcher. * Currently pregnant or planning to become pregnant. * On going legal action or disability claim.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Stanford Pain Management Center
RECRUITINGRedwood City, California, 94043, United States
More trials for these conditions
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- Can a smart brain implant outsmart chronic pain?
- Pain drug lyrica put to the test for rare limb condition – but trial stalls
- Teens with chronic pain try dance as medicine
- Brain scans aim to unlock secrets of chronic pain in kids
- Apple watch study to track CRPS pain triggers in kids cancelled