Can a new pill quiet the lingering fire of shingles nerve pain?
NCT ID NCT07758920
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This trial tests whether an experimental tablet called HL-1186 can reduce the persistent nerve pain that sometimes lingers after a shingles rash heals, a condition known as postherpetic neuralgia. About 200 adults with this pain will receive either HL-1186, a placebo, or the standard drug pregabalin for 12 weeks. Researchers will measure changes in daily pain scores and watch for side effects to see if HL-1186 is both safe and effective.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- HL-1186 tablet
- What this could lead to
- If successful, HL-1186 could offer a new oral option to reduce chronic nerve pain after shingles, potentially with fewer side effects than current treatments.
- What could go wrong
- This is an early Phase 2 trial with 200 participants, so results may not hold up in larger studies. The drug could also fail to outperform existing treatments or cause unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Aged ≥ 18 years, of either sex. 2. Pain persists for 1 month or more after healing of skin lesions in patients with herpes zoster. 3. Participants fully understand the purpose, characteristics, methods of the trial and possible AEs, voluntarily participate in the trial and sign the ICF, or have their legal guardian sign the ICF on their behalf. Exclusion Criteria: 1. Participants with any pain other than PHN, or with other diseases that the researcher considers to potentially affect the evaluation of PHN. 2. Participants who may be allergic to the active ingredients or excipients of HL-1186 Tablet, HL-1186 Tablet placebo, pregabalin capsule or pregabalin capsule placebo, have an allergic constitution, or have a history of allergies to ≥ 3 substances. 3. Participants who have used drugs that may damage nerves (such as tumor chemotherapy drugs) after being diagnosed with PHN. 4. The baseline NRS collection begins within the 5 half-lives following the last use of the prohibited drug. 5. Participants who have previously used pregabalin with inadequate efficacy or intolerance. 6. Clinically significant abnormalities in the 12-lead electrocardiogram (ECG) during the screening period, or complicated with severe cardiopulmonary diseases, which are deemed unsuitable for inclusion by the researcher. 7. Participants with a history of malignant tumors within 2 years prior to screening. 8. Participants who have undergone major surgery within 8 weeks prior to enrollment or plan to undergo any surgery during the trial period. 9. Participants with positive human immunodeficiency virus antibody, positive syphilis serological test, positive hepatitis B virus surface antigen with hepatitis B virus DNA \> ULN, or positive hepatitis C virus antibody with hepatitis C virus RNA \> ULN. 10. Participants with a history of alcoholism or drug abuse within 2 years before screening. 11. Female participants who are pregnant, breastfeeding (within 1 year after delivery), or with a positive pregnancy test. 12. Participants deemed by the investigator to be unsuitable for participating in this trial for any reason.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
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Genom att skicka in godkänner du våra Användarvillkor
Study contacts
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Contact
Email: •••••@•••••
Locations
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Peking University First Hospital
RECRUITINGBeijing, China
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