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Shingles nerve pain linked to higher dementia risk in massive study

NCT ID NCT07399288

Knowledge-focused Sponsor: China Medical University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at health records of nearly 69,000 adults aged 40 and older to see if those who develop lasting nerve pain after shingles (postherpetic neuralgia) have a higher chance of getting dementia later. Researchers compared people with and without this nerve pain, matching them by other health factors. The goal was to understand if the nerve pain itself is a risk factor for dementia, which could help with early detection or prevention.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the link is confirmed, it could lead to earlier monitoring or prevention strategies for dementia in people who have had shingles with nerve pain.
What could go wrong
This is an observational study, so it can only show an association, not cause and effect. The results may be influenced by other health factors not fully accounted for.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

68,786 people

The number who actually took part.

Started

Oct 2015

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population comprises adults aged 40 to 120 years with incident herpes zoster identified in the TriNetX Global Collaborative Network from 1 October 2015 to 31 December 2024. Exposure groups are defined by the presence or absence of recorded postherpetic neuralgia diagnoses within 90 to 365 days after the index herpes zoster date. Follow-up for outcomes starts at a 365-day landmark after index among individuals alive and free of the outcome at the landmark. Replication analyses are performed in the TriNetX Asia Pacific (APAC) network.

Ages

40 to 120 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 40 to 120 years with an incident herpes zoster diagnosis recorded between 1 October 2015 and 31 December 2024 in the TriNetX network. * A 3-year washout period with no recorded herpes zoster diagnosis before the index date. * Eligible for analysis at the 365-day landmark after the index date, defined as being alive and free of the specified outcome at the landmark. Exclusion Criteria: * Any record of the specified outcome before the 365-day landmark. * Missing data elements required to define exposure status within the prespecified time window.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease dementia herpes zoster Neuralgia, Postherpetic postherpetic neuralgia vascular dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dementia Herpes zoster Postherpetic neuralgia ( PHN )

Contacts and locations

Locations

  • China Medical University Hospital

    Taichung, Taichung City, 40447, Taiwan

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