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Could Botox-Like shots ease debilitating CRPS pain?

NCT ID NCT07473635

Symptom relief Sponsor: Bo Biering-Soerensen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a single injection of botulinum toxin (similar to Botox) around major nerves can safely reduce pain in people with Complex Regional Pain Syndrome (CRPS), a chronic condition causing severe pain and disability. Twenty adults with CRPS in one arm or leg will receive the injection and be followed for 12 weeks. The main goal is to see if the procedure is practical and safe, not yet to prove it works.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Incobotulinumtoxin-A (a type of botulinum toxin, like Botox)
What this could lead to
If this approach is safe and feasible, it could lead to a larger trial testing whether botulinum toxin injections can reduce pain and flare-ups in CRPS.
What could go wrong
This is a very small, early feasibility study with only 20 people. It is not designed to prove the treatment works, and there is a risk of side effects or worsening pain from the injection itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Are over the age of 18 * Have a diagnosis of CRPS type 1 or 2 in either one upper or one lower extremity which fulfils the Budapest research criteria * Have had the condition for at least 6 months * Rate CRPS as their primary pain condition * Have been on a stable analgesic regimen, including any rescue medications, for at least 1 month prior to the study and intend to maintain this regimen throughout the study * For pre-menopausal females: are using a safe and approved contraceptive * Speak, read, and understand Danish Exclusion Criteria: * Are allergic to botulinum toxin A * Have been treated with botulinum toxin A for any indication within 3 months prior to study start * Are diagnosed with myasthenia, Lambert-Eaton syndrome, amyotrophic lateral sclerosis, or any other condition which makes differentiation of CRPS-specific pain difficult * Have an ongoing infection in the affected limb * Do not intend to start physical therapy, psychotherapy, or any other non-pharmaceutical intervention aimed at reducing pain * Have used a topical analgesic treatment such as lidocaine patches within 1 week prior to study start or have been treated with capsaicin patches in the affected area within 3 months prior to study start * Have psychiatric comorbidities which are considered by the investigators to impact their ability to participate * Consume alcohol in excess of what is recommended by the Danish Health Ministry * Are active abusers of illicit narcotics * Are pregnant, lactating, or plan on becoming pregnant during the study period * Have any other condition or circumstance that, in the investigators' opinion, will hinder safe and timely participation and completion of the study

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Conditions

The condition(s) this trial relates to.

complex regional pain syndrome complex regional pain syndrome type 1 complex regional pain syndrome type 2

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRPS (complex regional pain syndrome) type I CRPS (complex regional pain syndromes) CRPS type II

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CRPS- and Nerve Pain Clinic, Rigshospitalet Glostrup

    RECRUITING

    Glostrup, Region Sjælland, 2600, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.