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AI decodes the mystery of persistent pain in rheumatoid arthritis

NCT ID NCT07769619

Knowledge-focused Sponsor: 4th Military Clinical Hospital with Polyclinic, Poland Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This observational study aims to understand why some people with rheumatoid arthritis (RA) continue to experience chronic pain even when their inflammation is well-controlled. Researchers will compare two groups of RA patients—those with active disease and those in remission without significant pain—using clinical assessments, blood tests, and optional brain activity monitoring. By analyzing genetic, molecular, and neurophysiological data with artificial intelligence, the study hopes to identify distinct pain-related subtypes and uncover biomarkers that predict persistent pain. The ultimate goal is to pave the way for more personalized, mechanism-based pain treatments in rheumatology.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better ways to predict and treat chronic pain in rheumatoid arthritis, even when inflammation is under control.
What could go wrong
This is an observational study, so it won't test any new treatment. The findings may not apply to all patients, and the AI models need validation before they can be used in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults with confirmed rheumatoid arthritis recruited during routine clinical care visits at a tertiary rheumatology referral center (4th Military Clinical Hospital with Polyclinic, Wrocław, Poland). The study population includes patients with active RA qualifying for biological therapy and patients in sustained clinical remission under biological therapy.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria - Study Group (Active RA) * Age ≥18 years. * Confirmed diagnosis of rheumatoid arthritis according to applicable classification criteria. * Active phase of the disease requiring initiation of biological therapy. * Qualification for treatment under the national drug program B.33: "Treatment of rheumatoid arthritis and juvenile idiopathic arthritis with aggressive course (ICD-10: M05, M06, M08)". * Ability to provide written informed consent. * Willingness to participate in clinical assessments, EEG, biological sample collection, and questionnaire-based evaluation. Exclusion Criteria - Study Group * Contraindications to biological therapy as defined by the Polish Society of Rheumatology recommendations and the National Health Fund (NFZ) requirements under the B.33 drug program. * Inability to provide informed consent. * Any condition that, in the opinion of the investigator, may interfere with study participation or data interpretation. Inclusion Criteria - Control Group (RA in Remission) * Age ≥18 years * Confirmed diagnosis of rheumatoid arthritis. * Ongoing biological therapy with sustained remission for at least 1.5 years and good tolerance of the treatment. * No current chronic pain reported in the clinical interview. * Ability to provide written informed consent. * Willingness to participate in study procedures, including biological sampling, EEG and questionnaire assessments.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Nociplastic Pain rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain Rheumatoid arthritis (RA

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 4th Military Clinical Hospital with Polyclinic (4WSzKzP SPZOZ)

    RECRUITING

    Wroclaw, 50-981, Poland

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