Which pain pill works best? new study aims to end the guesswork
NCT ID NCT04441034
First seen Apr 24, 2026 · Last updated Jun 20, 2026 · Updated 6 times
Summary
This study compares two widely used drug classes—anti-convulsants and anti-depressants—for treating chronic pain in 450 real-world patients. Unlike typical trials that exclude many patients, this one includes people with other health issues to get results that apply to more people. The goal is to see which drug works better and to build a tool that predicts which patients will respond best to each medication.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Stanford Pain Management Center
RECRUITINGRedwood City, California, 94063, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
anti-convulsant and anti-depressant medications
What this could lead to
If successful, this could help doctors choose the right pain medication for each patient, improving pain relief and reducing guesswork.
What could go wrong
This is a pragmatic trial focused on comparing existing drugs, not testing a new treatment. Results may show no clear winner, and the prediction model may not be accurate enough for widespread use.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.