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Hidden clues on CT: three signs that may pinpoint the nerve behind sciatica pain

NCT ID NCT07690449

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study examines whether three specific signs seen on CT scans — nerve-root swelling, tissue infiltration around the nerve, and increased density of the nerve — can identify the exact nerve root causing sciatica. Researchers reviewed planning CT scans from 400 adults with low-back and leg pain who were scheduled for CT-guided steroid injections. If these signs prove reliable, they could help doctors decide where to inject treatment more precisely.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If these CT signs reliably point to the painful nerve root, doctors could better target treatments like steroid injections, potentially improving outcomes for people with sciatica.
What could go wrong
This is a small, single-center retrospective study, so results may not apply to all patients. The signs are not yet proven to be accurate or useful in routine care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2024

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients referred to the Department of Diagnostic and Interventional Radiology of Pasteur 2 Hospital (Nice) for CT-guided infiltration of low-back sciatica, over the period 30 Jan 2024 to 11 Jul 2024.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult (\>= 18 years) * Low-back sciatica / radicular pain with a systematized distribution * Referred for CT-guided foraminal or peri-radicular infiltration at Pasteur 2 Hospital (Nice) between 30 Jan 2024 and 11 Jul 2024. * Available and interpretable pre-infiltration planning CT Exclusion Criteria: * Planning CT missing or not interpretable * Missing data on the three studied signs * Radicular pain of tumoral, infectious or recent traumatic origin * Spinal history precluding analysis of the studied root

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Conditions

The condition(s) this trial relates to.

Low Back Pain radiculopathy sciatica

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Low back pain Lumbosacral radiculopathy Sciatica

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU NICE

    RECRUITING

    Nice, Alpes Maritimes, 06000, France

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