Veterans test CBD for pain relief in new study
NCT ID NCT06213233
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether cannabidiol (CBD), a compound from cannabis, can ease chronic pain in 468 veterans. Participants take either CBD or a placebo for 28 days and report their pain levels. The goal is to see if CBD improves pain symptoms better than a dummy pill.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cannabidiol (CBD, Epidiolex)
- What this could lead to
- If it works, this could point toward a safe, non-opioid option for managing chronic pain in veterans.
- What could go wrong
- This is a mid-stage trial with a short 28-day treatment period, so long-term benefits are unknown. CBD may not outperform placebo, and individual responses vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 468 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2024
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Ability to read and speak English sufficiently to allow for written informed consent and patient-reported outcomes measures * Armed Services Veteran * All participants must have been enrolled in the MIVetsCan Pain Registry (HUM00223894) for at least 4 weeks and agree to continue participation in that study. * Reports moderate to severe chronic pain defined by protocol * Currently using or interested in using cannabis for pain management * Self-reported willingness to refrain from or not increase current Tetrahydrocannabinol (THC) or other cannabis product use (including CBD) during the study intervention or other cannabinoid use during the study intervention * Individuals of reproductive potential must agree to use acceptable birth control per protocol * Participants must also agree not to donate sperm or eggs during study drug administration * Willingness to attend all study visits (may be done virtually) * Ability to take and to swallow the study medication and be willing to adhere to the treatment regimen * Willingness to wear Fitbit or other similar sensor for passive-data collection * Willingness to fill out daily diary via smartphone to assess symptom status, study drug use, and other cannabis use Exclusion Criteria: * Not an Armed Services Veteran * Inability to provide informed consent (e.g., cognitive impairment, unable to sufficiently communicate in English) * Participant reports pregnancy or are nursing * Planning to move out of a state with legal recreational marijuana use during course of study * Risk for imminent harm - Suicidal ideation or wish to die as assessed per protocol * Any impairment, activity, behavior, or situation that in the judgment of the study team would prevent satisfactory completion of the study protocol * Participation in any other clinical trials over the course of this study * Medical or psychiatric conditions that in the judgment of study personnel would preclude participation in this study (e.g., psychosis, suicidal ideation; note that stable anxiety and depression are not exclusions) * Having a serious or unstable hepatic disease (e.g., non-alcoholic fatty liver disease or liver cirrhosis) * Individuals with major neurological disorders, such as dementia, Parkinson's disease, cognitive impairment, epilepsy, and seizures * Recent/new diagnosis of cancer within the past 3 years (other than localized melanoma, localized basal cell carcinoma, localized squamous cell carcinoma treated or untreated) * Current valproate and clobazam use per self-report or medical records * Self-reported allergies to sesame oil or cannabis/cannabinoids
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
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