Can a High-Tech Hot-Cold wrap beat a classic whirlpool for chronic pain?
NCT ID NCT07744269
First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time
Summary
This study tests whether a device that combines hot and cold therapy with gentle compression can reduce pain, swelling, and improve hand function in people with Complex Regional Pain Syndrome (CRPS) after a hand or wrist injury. Half of the participants will use this combined therapy, while the other half will receive standard whirlpool therapy. The goal is to see which approach offers better relief for this often painful and disabling condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Combined contrast therapy with intermittent compression using the Game Ready MED4 Elite device
- What this could lead to
- If effective, this approach could offer a more targeted, non-drug way to ease pain and swelling and speed recovery of hand function in people with post-traumatic CRPS.
- What could go wrong
- This is a small, early-stage trial, so results may not apply broadly. The therapy may not outperform whirlpool, and individual responses can vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2026
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients diagnosed with Complex Regional Pain Syndrome Type 1 (CRPS-I) according to the Budapest Criteria * Age between 18 and 80 years * CRPS developed following upper extremity trauma (e.g., hand or wrist fracture, soft tissue injury) * Symptom duration less than 3 months (subacute stage) * Ability and willingness to provide written informed consent and voluntarily participate in the study Exclusion Criteria: * Patients diagnosed with Complex Regional Pain Syndrome Type 2 (CRPS-II) or with evidence of peripheral nerve injury * History of peripheral neuropathy, Raynaud's phenomenon, or vascular circulation disorders * Presence of impaired skin integrity, open wounds, infection, or dermatological disease in the affected area * History of cold or heat intolerance, cold urticaria, or hypersensitivity to thermal modalities * Active infection or severe edema in the affected extremity * Presence of serious systemic diseases (cardiovascular, pulmonary, renal, or neurological) * Receipt of similar physical therapy or modality-based treatment within the past 3 months
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Etlik City Hospital, Department of Physical Medicine and Rehabilitation
RECRUITINGAnkara, Yenimahalle, 06370, Turkey (Türkiye)
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