Surgery offers new hope for chronic pain sufferers
NCT ID NCT07263256
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested surgery to treat Complex Regional Pain Syndrome (CRPS) in the upper limb. 74 adults with CRPS who had not improved with other treatments received either nerve decompression or correction of a specific structural problem. Pain levels were measured before surgery, at 10-12 days, and at three months to see how much and how quickly pain changed.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Surgery (median nerve decompression and lesion-specific correction)
- What this could lead to
- If successful, this surgical approach could offer a new way to reduce pain for people with Complex Regional Pain Syndrome who haven't improved with other treatments.
- What could go wrong
- This is a small, completed study without a control group, so results may not apply to everyone. Surgery carries risks like infection or nerve damage, and pain relief may not last.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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74 people
The number who actually took part.
- Started
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Jan 2014
- Finished
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Dec 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosed Complex Regional Pain Syndrome (CRPS) according to Budapest criteria * Age ≥ 18 years * Persistent symptoms despite previous conservative treatment * Ability to understand the study information and provide informed consent * Ability to adhere to postoperative follow-up Exclusion Criteria: * Active local or systemic infection * Severe uncontrolled psychiatric illness * Coagulopathy or anticoagulation therapy contraindicating surgery * Pregnancy * Previous extensive surgical interventions on the same site interfering with planned procedure * Inability to comply with follow-up * Any other condition that, in the opinion of the investigator, makes participation unsafe
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital Nové Město Na Moravě
Nové Město na Moravě, Czech Republic, 592 31, Czechia
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