Can a single ketamine infusion ease daily headaches for months?

NCT ID NCT05306899

Recruiting now Symptom relief Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

First seen Nov 17, 2025 · Last updated May 22, 2026 · Updated 17 times

Summary

This study tests whether a single high-dose intravenous ketamine infusion can reduce the number and severity of headache days in people with chronic daily headaches (15+ headache days per month). 56 adults aged 18-75 will receive either ketamine or a placebo (saline) and be followed for three months. The goal is to see if ketamine can safely provide lasting relief and improve quality of life.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Toronto Western Hospital
RECRUITING

Toronto, Ontario, M5T 2S8, Canada

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Women's College Hospital
RECRUITING

Toronto, Ontario, M5S 1B2, Canada

Contact Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

CHRONIC DAILY HEADACHE