Teen headache mystery: could uric acid be a clue?
NCT ID NCT07460830
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares uric acid levels in 80 adolescents (12-18 years) with and without primary headaches. Researchers aim to see if there is a link between uric acid and headaches, which could help understand what causes them. Participants will provide a blood sample and have their height and weight measured.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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May 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of adolescents aged 12-18 years who present to pediatric neurology outpatient clinics with a confirmed diagnosis of primary headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3). The control group includes age- and sex-matched adolescents attending general pediatric outpatient clinics who have no history of recurrent headaches or any chronic medical or psychiatric disorders. Participants in both groups must have adequate cognitive ability to understand and complete the study instruments. Exclusion criteria include any neurological disorder other than primary headache, previously diagnosed psychiatric or autoimmune diseases, chronic infections, severe cardiac failure, metabolic or inflammatory disorders, obesity, significant hepatic or renal impairment, regular use of psychotropic medications, history of polycythemia, or use of drugs known to affect uric acid metabolism within 2-4 weeks before enrollment.
- Ages
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12 to 18 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Inclusion Criteria (Cases): Adolescents aged 12-18 years presenting to pediatric neurology outpatient clinics Diagnosis of primary headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3) (e.g., 1.1, 1.2, etc.) Diagnosis confirmed by a pediatric neurologist following a comprehensive clinical evaluation Sufficient cognitive ability to understand and complete study instruments * Inclusion Criteria (Controls): Adolescents aged 12-18 years presenting to general pediatric outpatient clinics No history of recurrent headaches No chronic medical or psychiatric disorders Matched with the case group for age and sex Exclusion Criteria: * History of neurological disorders other than primary headache * Previously diagnosed psychiatric conditions * Autoimmune diseases, chronic infections, severe cardiac failure, metabolic or inflammatory disorders, obesity, or significant hepatic or renal impairment * Regular use of psychotropic medications or a history of polycythemia * Use of drugs known to affect uric acid metabolism within 2-4 weeks prior to enrollment * Cognitive or developmental disabilities limiting the ability to understand or complete study instruments
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
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The official record
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A doctor treating you
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