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Can a detailed map of pain nerves unlock new chronic pain treatments?

NCT ID NCT07740681

Knowledge-focused Sponsor: King's College Hospital NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study aims to create a detailed map of the sensory nerves that transmit pain signals in humans, to better understand why chronic pain develops. Researchers will use a technique called microneurography, which involves inserting a fine electrode into a nerve to record the activity of individual nerve fibers. This will be done in both healthy volunteers and people with chronic pain, and the results will be combined with lab studies to link nerve activity to molecular characteristics. The goal is to identify specific nerve types involved in chronic pain, which could guide the development of more effective, personalized treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Microneurography (a diagnostic test that records electrical activity from individual nerve fibers)
What this could lead to
If successful, this research could create a detailed map of the human pain system, potentially guiding the development of more effective, personalized treatments for chronic pain.
What could go wrong
This is an early-stage, observational study focused on understanding mechanisms, not testing a treatment. It may not directly lead to new therapies, and the technique is invasive, carrying risks of discomfort or nerve injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

100 patients with ongoing neuropathic pain in the context of a possible small fibre neuropathy or C-fibre dysfunction. 100 healthy volunteers.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between 18 and 75 years of age. * Male and female. * In the capacity to understand and sign an Informed Consent Form. * Willing and able to comply with scheduled visits and study procedures. * Criteria for chronic pain participants: * Ongoing neuropathic pain in the context of a possible small fibre neuropathy or C-fibre dysfunction * Criteria for healthy participants: * Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history and a full physical examination. Exclusion Criteria: * Previous diagnosis of an established autoimmune condition or dermatological conditions affecting skin afferents (e.g. psoriasis, lupus, vitiligo, dermatitis…). * Application of local anaesthetics or steroid injections within 35 days prior to the microneurography visit. * Unsuitable anatomy of the superficial peroneal nerve (i.e. nerve cannot be seen or palpated at the dorsum of the foot/ankle) * Infection, disease (dermatologic or vascular), ongoing pain or recent trauma or surgery that may affect study assessments. * Current use of anticoagulant therapy.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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More trials for these conditions

Other studies related to the condition(s) this trial covers.