Turmeric and black pepper: a natural route to fibromyalgia relief?
NCT ID NCT07753018
First seen Aug 07, 2026 · Last updated Aug 12, 2026 · Updated 2 times
Summary
This trial tests whether a daily supplement containing curcumin (from turmeric) and piperine (from black pepper) can reduce pain and improve quality of life in women with fibromyalgia. Participants will be randomly assigned to receive either the active supplement or a placebo for three months. Researchers will measure pain intensity, disease impact, and markers of inflammation and oxidative stress to see if this natural approach offers real benefits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Curcumin and piperine dietary supplement
- What this could lead to
- If effective, this supplement could offer a natural, well-tolerated option to reduce pain and improve daily function for people with fibromyalgia.
- What could go wrong
- This is a small, early-stage trial, and supplements often show less benefit than hoped. Results may not apply to all patients, and side effects or interactions are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult women aged ≥18 years. * Patients with confirmed diagnosis of fibromyalgia, according to 2022 ACR Fibromyalgia criteria. Exclusion Criteria: * Diabetic patients (HbA1c ≥ 6.5). * Patients with chronic inflammatory or autoimmune diseases other than FM. * Patients allergic to curcumin or piperine. * Patients receiving other anti-inflammatory medications. * Severe hepatic or renal impairment. * Patients receiving anticoagulant medications (e.g., clopidogrel). * Pregnancy or lactation. * Participation in another clinical trial
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Get notified about this study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Suez Canal University hospitals
Ismailia, 41511, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Ear stimulation may tame both fibromyalgia pain and PTSD
- Social media support groups may ease loneliness in fibromyalgia
- Teaching the brain about pain may boost exercise benefits for chronic pain sufferers
- AI coach could help fibromyalgia patients exercise at home
- Brain zaps might quiet fibromyalgia pain without drugs
- Forest therapy tested as natural pain relief for fibromyalgia