New combo therapy targets ringing ears without drugs
NCT ID NCT07468318
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining physiotherapy, structured exercise, and psychological support can reduce the burden of chronic tinnitus (ringing in the ears) in 160 adults aged 18-70. Participants will be randomly assigned to either the 8-week multimodal program or a control group, with follow-ups up to 24 months. The main goal is to measure changes in tinnitus-related handicap using a standard questionnaire.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 160 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2027
An estimate. Start dates often move.
- Expected to finish
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Dec 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18-70 years (inclusive) * Chronic subjective tinnitus present for ≥6 months * Tinnitus Handicap Inventory (THI) score ≥18 points (indicating at least mild tinnitus handicap) * Positive somatosensory modulation test: ability to reproducibly modulate tinnitus (change in loudness, pitch, or quality) through at least one of the following manoeuvres: * Jaw movements (mouth opening, lateral excursion, protrusion, clenching) * Neck movements (flexion, extension, rotation, lateral flexion) * Pressure on specific head/neck muscles * Eye movements or shoulder elevation * Willing and able to attend all study sessions over 28 weeks * Adequate cognitive capacity to understand study procedures and complete questionnaires in the Czech language * Signed written informed consent Exclusion Criteria: * Audiological/ENT Exclusions: * Objective or pulsatile tinnitus * Active ear pathology requiring treatment: * Acute otitis media or externa * Chronic suppurative otitis media * Cholesteatoma * Meniere's disease with recent vertigo attacks (\<3 months) * Suspected retrocochlear pathology: * Acoustic neuroma (vestibular schwannoma) * Cerebellopontine angle tumor * Neurological Exclusions: * Neurological disease affecting brainstem or auditory pathways: * Multiple sclerosis with brainstem involvement * Stroke affecting auditory pathways * Brain tumor * Epilepsy or active seizure disorder * Musculoskeletal Exclusions: * Contraindications to manual therapy: * Severe cervical spine instability * Rheumatoid arthritis with atlantoaxial instability * Down syndrome * Vertebrobasilar insufficiency * Severe osteoporosis with fracture risk * Recent cervical spine surgery (\<6 months) * Recent head or neck trauma (\<3 months) * Ongoing physiotherapy or manual therapy for temporomandibular joint or cervical spine (\<3 months prior to enrollment) * Psychiatric Exclusions: * Severe psychiatric disorder: * Active psychosis * Severe depression requiring inpatient treatment * Acute suicidal ideation (PHQ-9 item 9 score ≥2) * Active substance abuse disorder * Other Exclusions: * Pregnancy (due to modifications needed in physical examination and treatment) * Ongoing litigation or compensation claims related to tinnitus or hearing loss * Current participation in another interventional clinical trial * Expected change of residence or long-term absence (\>2 weeks) during the study period * Unable or unwilling to comply with study procedures and attend all sessions
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Charles University Faculty of physical education and sport
Prague, Czechia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Brain-Training trial aims to turn down the ringing
- Turmeric compound tested against the ringing in millions of ears
- Rewiring the brain to silence Tinnitus's grip?
- Ancient cupping therapy put to the test for ringing ears
- Tinnitus relief from your couch: online counseling tested
- Could migraine meds silence tinnitus? new trial investigates