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New combo therapy targets ringing ears without drugs

NCT ID NCT07468318

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether combining physiotherapy, structured exercise, and psychological support can reduce the burden of chronic tinnitus (ringing in the ears) in 160 adults aged 18-70. Participants will be randomly assigned to either the 8-week multimodal program or a control group, with follow-ups up to 24 months. The main goal is to measure changes in tinnitus-related handicap using a standard questionnaire.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-70 years (inclusive) * Chronic subjective tinnitus present for ≥6 months * Tinnitus Handicap Inventory (THI) score ≥18 points (indicating at least mild tinnitus handicap) * Positive somatosensory modulation test: ability to reproducibly modulate tinnitus (change in loudness, pitch, or quality) through at least one of the following manoeuvres: * Jaw movements (mouth opening, lateral excursion, protrusion, clenching) * Neck movements (flexion, extension, rotation, lateral flexion) * Pressure on specific head/neck muscles * Eye movements or shoulder elevation * Willing and able to attend all study sessions over 28 weeks * Adequate cognitive capacity to understand study procedures and complete questionnaires in the Czech language * Signed written informed consent Exclusion Criteria: * Audiological/ENT Exclusions: * Objective or pulsatile tinnitus * Active ear pathology requiring treatment: * Acute otitis media or externa * Chronic suppurative otitis media * Cholesteatoma * Meniere's disease with recent vertigo attacks (\<3 months) * Suspected retrocochlear pathology: * Acoustic neuroma (vestibular schwannoma) * Cerebellopontine angle tumor * Neurological Exclusions: * Neurological disease affecting brainstem or auditory pathways: * Multiple sclerosis with brainstem involvement * Stroke affecting auditory pathways * Brain tumor * Epilepsy or active seizure disorder * Musculoskeletal Exclusions: * Contraindications to manual therapy: * Severe cervical spine instability * Rheumatoid arthritis with atlantoaxial instability * Down syndrome * Vertebrobasilar insufficiency * Severe osteoporosis with fracture risk * Recent cervical spine surgery (\<6 months) * Recent head or neck trauma (\<3 months) * Ongoing physiotherapy or manual therapy for temporomandibular joint or cervical spine (\<3 months prior to enrollment) * Psychiatric Exclusions: * Severe psychiatric disorder: * Active psychosis * Severe depression requiring inpatient treatment * Acute suicidal ideation (PHQ-9 item 9 score ≥2) * Active substance abuse disorder * Other Exclusions: * Pregnancy (due to modifications needed in physical examination and treatment) * Ongoing litigation or compensation claims related to tinnitus or hearing loss * Current participation in another interventional clinical trial * Expected change of residence or long-term absence (\>2 weeks) during the study period * Unable or unwilling to comply with study procedures and attend all sessions

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Charles University Faculty of physical education and sport

    Prague, Czechia

More trials for these conditions

Other studies related to the condition(s) this trial covers.