Can acupuncture replace painkillers for facial nerve pain?
NCT ID NCT06977932
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can reduce pain in people with trigeminal neuralgia, a condition causing severe facial pain. 126 participants will either get real electroacupuncture or a sham version, while continuing their usual medication. The goal is to see if electroacupuncture can offer a safer alternative to carbamazepine, which can cause addiction and other side effects.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- electroacupuncture
- What this could lead to
- If it works, this could offer a drug-free option to manage trigeminal neuralgia pain with fewer side effects.
- What could go wrong
- This is a small, early-stage trial with only 126 participants. The sham acupuncture group may also show some benefit, making it hard to prove real effect.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 126 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Diagnostic Criteria Diagnosis was based on the criteria for trigeminal neuralgia (TN) as defined in the third edition of the International Classification of Headache Disorders (ICHD-3) published by the International Headache Society (IHS) in 2018. The diagnostic criteria included: 1. recurrent unilateral facial pain occurring in the distribution of one or more divisions of the trigeminal nerve, without radiation outside the trigeminal territory, and meeting criteria (2) and (3); 2. pain presenting with all of the following characteristics: ① paroxysmal attacks lasting from a few seconds to 2 minutes; ② severe intensity; * electric shock-like, stabbing, or sharp quality; 3. pain triggered by innocuous stimuli within the affected trigeminal distribution; 4. exclusion of other facial pain disorders classified in ICHD-3. Inclusion Criteria All of the following criteria had to be met for study enrollment: * fulfillment of the TN diagnostic criteria as stated above; * age between 18 and 80 years, inclusive, irrespective of sex; * receiving a stable daily dose of carbamazepine (200-400 mg); ④ consciousness clear, with intact pain perception and discrimination, and able to communicate effectively; ⑤ voluntary participation with written informed consent provided by the patient or their legal guardian/authorized representative. Exclusion Criteria Participants were excluded if they met any of the following: * comorbid epilepsy, head injury, or other relevant neurological disorders; * significant impairment of cardiac, hepatic, or renal function; * cognitive dysfunction, aphasia, psychiatric conditions, or inability to cooperate with treatment; * poorly controlled hypertension or hyperglycemia; ⑤ recent diagnosis of severe anxiety or depression; ⑥ pregnancy or lactation; ⑦ presence of a cardiac pacemaker or other contraindications to electroacupuncture therapy; ⑧ current participation in another clinical trial.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Pain relief showdown: one drug vs. two for facial nerve pain
- New combo therapy aims to calm face pain attacks
- Laser showdown: which light therapy zaps facial pain best?