Could a headband be the answer to chronic migraines?
NCT ID NCT07214454
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a headband-like device called Nettle that delivers gentle electrical stimulation to parts of the brain involved in pain. Twenty adults with chronic migraine will use it at home for 20 minutes each day over three months. The main goal is to see if people can stick with the treatment and complete daily headache diaries, not yet to prove it works.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subjects aged 18-70 years 2. Fulfil the International Classification of Headache Disorders -3 (ICHD-3) criteria for chronic migraine, diagnosed by a headache specialist, at least 1 year prior to entering the trial 3. Subject is willing to keep headache medications stable for two weeks prior to entering the study and for the duration of the study. 4. Access to a smart phone to use the mobile application to control the device and use the Headache Pro app to record headaches. A paper diary may be used instead of the Headache Pro app Id required by individual patients. 5. Subject is able to provide written informed consent prior to participation in the study 6. Females of childbearing potential agree to use an effective method of contraception from the time consent is signed until treatment discontinuation. Effective methods of contraception acceptable for this trial are the oral contraceptive pill, patch, implant, injection, ring, intra-uterine system, copper coil, barrier methods, partner vasectomy or abstinence. Participants are considered not of child bearing potential if they are surgically sterile (i.e. they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal 7. If there is any possibility of pregnancy, females of childbearing potential should have a negative pregnancy test within 7 days of commencing the treatment phase. 8. Subject must be willing and able to provide written informed consent. Exclusion Criteria: 1. Epilepsy or history of seizures 2. Current or planned pregnancy during the study timeframe 3. Active suicidal thoughts 4. Pre-existing neurological or neuropsychiatric condition 5. Lesion, tumour or other defect in skull or brain 6. Implant inside skill, cochlear implant or implanted hearing aid. 7. Implanted medical device e.g. pacemaker or neurostimulator 8. Use of other stimulation devices such as spinal cord stimulators, vagal nerve stimulation, auricular nerve stimulator or deep brain stimulation. 9. Concurrent medication overuse 10. Use of cranial botulinum toxin injections or CGRP inhibitors in the past 6 months 11. Current or recent (within three months) participation in another clinical trial. 12. Planned surgical or significant medical intervention during the study period which may affect the study results, at the discretion of the chief investigator. 13. Lacking mental capacity to give informed written consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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Other studies related to the condition(s) this trial covers.
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