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Stitch showdown: which suture prevents hernia best?

NCT ID NCT07280975

Disease control Sponsor: Lady Reading Hospital, Pakistan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two common stitch materials—absorbable Vicryl and non-absorbable Prolene—for closing the abdominal wall after surgery. Researchers will track 156 patients in Pakistan for 6 months to see which suture leads to fewer hernias, infections, and less pain. The goal is to provide clear guidance for surgeons on the best choice.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Polyglactin 910 (Vicryl) suture and Polypropylene (Prolene) suture
What this could lead to
If this trial succeeds, it could show which suture material is better at preventing complications like hernia and infection after abdominal surgery.
What could go wrong
This is a small, early-stage trial (156 people) in one country, so results may not apply everywhere. The study hasn't started yet, and outcomes may not be conclusive.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 156 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age: 18-70 years. 2. Type of Surgery: Patients undergoing elective or emergency midline laparotomy. 3. Wound Classification: Clean or clean-contaminated wounds (CDC Class I or II). 4. Ability to Provide Informed Consent: Participants must be able to understand and sign the informed consent form. 5. Availability for Follow-Up: Participants must be available for 6 months follow-up. Exclusion Criteria: 1. Contaminated or Dirty Wounds: Patients with CDC Class III or IV wounds. 2. Immunocompromised Conditions: Patients on steroids, chemotherapy, or those with HIV. 3. Previous Midline Laparotomy with Incisional Hernia: Patients who have a history of incisional hernia after midline laparotomy. 4. Severe Malnutrition: Patients with BMI \< 16 kg/m² or albumin \< 2.5 g/dL. 5. Emergency Laparotomy with Hemodynamic Instability: Patients who are unstable or in a critical condition. 6. Pregnancy: Pregnant women. 7. Need for Temporary Abdominal Closure or Planned Reoperation: Patients requiring staged reoperation or temporary closure.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Incisional Hernia Postoperative Complications Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abdominal surgery Chronic pain Incisional hernia Rectus sheath closure Surgical site infection (SSI) Wound dehiscence

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Lady Reading Hospital, Department of General Surgery

    Peshawar, Khyber Pakhtunkhwa, 25000, Pakistan

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