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Could a Nerve-Zapping ear device ease chronic pain?

NCT ID NCT07711392

Symptom relief Sponsor: Liv Hospital Vadistanbul Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study tests whether adding a gentle electrical stimulation to the ear — targeting the vagus nerve — can improve pain and function in adults with complex regional pain syndrome type I (CRPS-I) affecting the hand or arm. All participants receive standard rehabilitation, but half also get active nerve stimulation while the other half gets a sham device. Researchers measure pain, swelling, hand function, and quality of life over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcutaneous auricular vagus nerve stimulation (taVNS) added to standard rehabilitation
What this could lead to
If effective, this approach could offer a non-invasive, drug-free way to ease pain and improve daily function for people with CRPS.
What could go wrong
This is a small, early-stage trial with only 20 participants, so results may not apply widely. The treatment may not provide significant benefit over standard rehab alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of complex regional pain syndrome type I according to the Budapest diagnostic criteria * Age 18 to 65 years * CRPS type I affecting the hand following a traumatic cause, including surgery, fracture, and/or immobilization of the hand or upper extremity * Willingness to participate in the study and provision of written informed consent Exclusion Criteria: * Diagnosis of complex regional pain syndrome type II * CRPS type I developing after stroke * Acute or post-acute rehabilitation following hand tendon repair * Presence of a comorbid condition that may substantially affect functional status or health-related quality of life, including decompensated heart failure, chronic kidney failure, or malignancy * Arthritis affecting the hand * Acute arterial or venous thrombosis of the upper extremity * History of arterial or venous injury of the upper extremity

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Conditions

The condition(s) this trial relates to.

complex regional pain syndrome complex regional pain syndrome type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Complex regional pain syndrome type I

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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Other studies related to the condition(s) this trial covers.