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Electric zaps to the brain may tame chronic migraine

NCT ID NCT07743814

Symptom relief Sponsor: Dr. Ram Manohar Lohia Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This trial tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce the number of headache days in people with chronic migraine. Participants will receive either real or sham (inactive) stimulation over the motor cortex during three sessions, while continuing their usual preventive medications. The study tracks headache frequency over 12 weeks to see if the stimulation makes a meaningful difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial direct current stimulation (tDCS) — a non-invasive brain stimulation technique using a mild electrical current applied to the scalp over the primary motor cortex.
What this could lead to
If effective, tDCS could offer a drug-free option to reduce headache frequency in chronic migraine, potentially helping those who cannot tolerate preventive medications.
What could go wrong
This is a small early-stage trial with only 32 participants, and the effect may be modest or not lasting. As with any brain stimulation, there is a small risk of discomfort or side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients aged 18-60 years diagnosed with chronic migraine as per ICHD-3. 2. Patients who were on a minimum of one concomitant preventive medication for not less than three months duration and a dose that was stable for at least one month prior to randomization. 3. Willingness to provide informed consent and maintain a headache diary. Exclusion Criteria: 1. Patients with neurologic diseases such as tumours, seizures, dementia, meningitis, stroke, etc. 2. Patients with barbiturate/opioid overuse or complications due to NSAID overuse. 3. Patients failing to complete headache diary for more than 6 non-consecutive days during baseline. 4. Illiterate patients without a caregiver to maintain the diary. 5. Patients with pacemakers, cochlear implants. 6. Pregnant women.

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Conditions

The condition(s) this trial relates to.

Headache headache disorder migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic migraine headache

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital

    New Delhi, 110001, India

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