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Blood clots after severe limb injuries may predict chronic pain

NCT ID NCT07475910

Knowledge-focused Sponsor: Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 150 adults with severe arm or leg injuries to see if developing a blood clot raises the risk of long-term pain. Participants are enrolled within 72 hours of hospital admission and monitored for six months. The goal is to understand how blood clots and pain are connected, which could improve care and recovery planning.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If it succeeds, this could help doctors better predict and prevent long-term pain after severe limb injuries.
What could go wrong
This is an observational study, not a treatment trial. It may find no clear link between blood clots and pain, or results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will include adult patients (≥18 years) with major upper or lower limb trauma requiring surgical treatment and/or prolonged immobilization (≥72 hours). Participants will be recruited from trauma centers managing severe civilian and combat-related injuries. Eligible patients will be enrolled within 72 hours of hospital admission. The cohort will include patients with various mechanisms of injury, including blast injuries, fragmentation injuries, gunshot wounds, and other high-energy trauma. Participants will be followed prospectively for up to 6 months to evaluate the association between venous thromboembolism (VTE) and the development of persistent post-traumatic pain.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Major upper or lower limb trauma * Surgical treatment and/or immobilization ≥72 hours * Enrollment within 72 hours of admission * Informed consent Exclusion Criteria: * Pre-existing chronic pain unrelated to trauma (investigator judgment) * Therapeutic anticoagulation prior to trauma * Cognitive inability to complete follow-up * Expected survival \<48 hours

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome neuralgia venous thromboembolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain Chronic pain due to injury Phantom limb pain after amputation Vte (venous thromboembolism)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Superhumans War Trauma Center

    Lviv, Ukraine

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