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Could a single dose of ketamine during heart surgery stop Long-Term pain?

NCT ID NCT07490457

Symptom relief Sponsor: Bursa City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will test whether giving a single dose of ketamine during open-heart surgery can reduce chronic pain that often lingers for months after the operation. Researchers will compare 100 adults who receive either ketamine or a placebo during surgery, then track their pain levels and painkiller use for up to 6 months. If successful, this simple addition to anesthesia could improve recovery and reduce reliance on opioids.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketamine
What this could lead to
If it works, this could point toward a simple way to prevent long-term pain after open-heart surgery and reduce the need for strong painkillers.
What could go wrong
This is a small, early-stage trial (100 people) that hasn't started yet. The results may not apply to all heart surgery patients, and ketamine can cause side effects like confusion or hallucinations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA II-III, * Patients scheduled for elective on-pump open cardiac surgery via median sternotomy. Exclusion Criteria: * Emergency surgery requirement * Need for reoperation * Requirement for postoperative re-intubation * History of opioid use * Preoperative diabetic neuropathy or autonomic dysfunction * Hepatic or renal dysfunction * History of neuropathic pain * Neurocognitive disorders such as psychosis or dementia * Use of antidepressants or antipsychotics * Body mass index (BMI) \> 40

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac anaesthesia Chronic pain Ketamine Pain Post operative pain, acute Post operative pain, chronic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Bursa City Hospital,

    Bursa, nilüfer, Turkey (Türkiye)

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