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Twitch test: simple muscle sign may predict neck pain relief success

NCT ID NCT05450679

Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 15, 2026 · Updated 3 times

Summary

This study looks at whether muscle twitching in the neck during a standard pain treatment (radiofrequency ablation) can help predict who will get good pain relief. Researchers will grade twitching in 60 adults with chronic neck pain and then check if those with more twitching had better outcomes. The goal is to find a simple, real-time clue that doctors can use during the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cervical Radiofrequency Ablation (RFA)
What this could lead to
If muscle twitching during the procedure predicts better pain relief, doctors could use this simple sign to improve treatment success for neck pain.
What could go wrong
This is a small, observational study (60 people) that only looks for a link, not a new treatment. The finding may not apply to all patients or guarantee better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

69 people

The number who actually took part.

Started

Sep 2022

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Only patients who have already been deemed candidates by their primary pain physician for a cervical radiofrequency ablation (RFA) (e.g. \>/= 50% relief from a diagnostic cervical medial branch block) will be recruited.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Cervical facet arthropathy based on history and physical exam (e.g. axial cervical neck pain, paraspinal tenderness, no pain referral below the ipsilateral shoulder) * Radiologic evidence of cervical pathology consistent with symptoms if MRI is available * Pain duration of greater than 3 months * Obtained 50% or greater pain relief from at least 1 diagnostic cervical medial branch block of the identical medial branch nerves targeted for RFA Exclusion Criteria: * Untreated coagulopathy * Signs or symptoms of cervical myelopathy * Signs or symptoms of cervical radiculitis/radiculopathy * Allergic reactions to local anesthetics * Serious psychiatric disorder (e.g. uncontrolled or refractory depression) that might preclude optimal outcome * Poorly controlled medical condition (e.g. pacemaker that cannot be switched off, unstable angina) * Pregnancy

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Neck Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical facet joint pain Chronic pain Neck pain

Contacts and locations

Locations

  • Johns Hopkins Hospital

    Baltimore, Maryland, 21287, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.