Unlocking the genetic roots of fibromyalgia's pain puzzle
NCT ID NCT04624581
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This study investigates whether genetic differences and altered pain processing contribute to fibromyalgia, a condition marked by widespread pain and increased sensitivity to painful stimuli. Researchers will compare 260 adults with fibromyalgia to a matched control group, measuring pain thresholds via a nerve reflex test and analyzing genetic variations. The goal is to better understand the biological mechanisms behind fibromyalgia, which could inform future diagnostic or treatment strategies.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Electrophysiological measurement of reflex nociceptive flexion threshold (RIII reflex) using Nicolet Vicking device
- What this could lead to
- If successful, this research could uncover genetic markers that help explain why fibromyalgia develops, potentially leading to more personalized diagnosis or treatment approaches.
- What could go wrong
- This is an observational study, so it won't test a treatment. The findings may not directly translate into new therapies, and genetic associations may be complex and require further validation.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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260 people
The number who actually took part.
- Started
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Nov 2020
- Finished
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Jan 2022
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Patient Inclusion criteria : * Patient between 18 and 65 years old (included), * Patient with fibromyalgia according to the criteria of the 2016 ACR, * Patient weighing more than 45kg * Cooperation and understanding sufficient to comply with the requirements of the study, * Acceptance to give written consent, * Affiliation to the French Social Security system, Patient exclusion criteria : * treated with antibiotics in the three months prior to inclusion, * who has reported gastroenteritis in the two months prior to inclusion, * having a medical and / or surgical history judged by the investigator or his representative to be incompatible with the test * of childbearing age not using an effective contraceptive method, pregnant or breastfeeding woman. * participating in another clinical trial, or being in the exclusion period, or having received a total amount of benefits exceeding EUR 4500 over the 12 months preceding the start of the trial, * benefiting from a measure of legal protection (guardianship, guardianship, deprivation of liberty, safeguard of justice), Subject inclusion criteria: * Aged of more than 18 years, * weighing more than 45kg * non-painful subjects matched by age (+/- 5 years), by sex, and by menopausal status for women, * Cooperation and understanding sufficient to comply with the requirements of the study, * Acceptance of written consent, * Affiliation to the French Social Security system, * Registration or acceptance of registration in the National Register of Volunteers participating in research. Subject exclusion criteria : * treated with antibiotics in the three months prior to inclusion, * who has reported gastroenteritis in the two months prior to inclusion, * Medical and / or surgical history judged by the investigator or his representative to be incompatible with the test, * Intake of any drugs in the 7 days before inclusion, * Pregnant or nursing woman * Participating in another clinical trial, or within the exclusion period, or having received a total amount of compensation in excess of EUR 4500 over the 12 months preceding the start of the trial, * Benefiting from a measure of legal protection (curatorship, guardianship, safeguard of justice ...)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU de Clermont-Ferrand
Clermont-Ferrand, 63000, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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