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Rewiring the brain to fight back pain?

NCT ID NCT05169918

Symptom relief Sponsor: Istanbul University - Cerrahpasa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial tests whether sensory discrimination training—a technique that sharpens the brain's ability to sense touch—can reduce pain and improve function in people with chronic low back pain linked to central sensitization. Participants will be randomly assigned to receive either this brain-focused training or standard core stabilization exercises over 10 weeks. Researchers will measure changes in touch accuracy, pain sensitivity, and daily function to see if retraining the brain offers a new way to ease persistent back pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sensory discrimination training (a type of brain retraining that sharpens touch perception) compared with core stabilization exercises
What this could lead to
If it works, this could point toward a new non-drug therapy for chronic low back pain that targets the brain's role in pain.
What could go wrong
This is a small early-stage trial, so results may not apply broadly. The training may not outperform standard exercises, and benefits could be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

27 people

The number who actually took part.

Started

Nov 2022

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * To be between 30 and 60 years old * To have pain lasting longer than 3 months * To have pain intensity greater than 4 out of 10 * To have pain that is not compatible with anatomical structures and is widespread * To get score of 40 or more from the Central Sensitization Inventory Exclusion Criteria: * Inability to perceive the sense of touch in the waist * Being pregnant * Using a pacemaker or being diagnosed with heart disease * Having an open wound in the waist * Using drugs that affect the central system (dopamine, etc.) * Having a history of surgery related to the spine * Presence of a neurological injury or disease * Having a Body Mass Index of 30 or more * To have a diagnosis of fibromyalgia

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Conditions

The condition(s) this trial relates to.

Back Pain Chronic Pain chronic pain syndrome Low Back Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Back pain Central sensitisation Chronic pain

Contacts and locations

Locations

  • Istanbul University-Cerrahpaşa

    Istanbul, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.