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Vitamin c may ward off Post-Surgery pain syndrome

NCT ID NCT02390505

Prevention Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking vitamin C before and after planned upper limb surgery could prevent complex regional pain syndrome (CRPS), a chronic pain condition. Nearly 1,000 adults participated, receiving either vitamin C or a placebo. The goal was to see if vitamin C reduces CRPS occurrence at 6 months after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin C
What this could lead to
If it works, this could provide a simple, low-cost way to prevent a painful chronic condition after upper limb surgery.
What could go wrong
The trial is completed but results are not yet widely known. Vitamin C may not reduce CRPS risk, and individual factors like allergies or hemochromatosis could limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

995 people

The number who actually took part.

Started

Jul 2016

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients over 18 yo * patients undergoing major surgery of the upper limb * patients able to give their consent to follow the protocol of treatment and monitoring. Exclusion Criteria: * children, * patients under guardianship, * pregnant or lactating women, * patients with hemochromatosis, * allergy or known hypersensitivity to one of the molecules of treatment, * patients suffering or having already suffered from complex regional pain syndrome type 1 or type 2, * patients unable due to personal or professional mobility, to conduct post-operative follow up, * patients undergoing surgery with nerve suture with nerve graft, emergency surgery, * patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, * patients with chronic kidney disease

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Conditions

The condition(s) this trial relates to.

complex regional pain syndrome complex regional pain syndrome type 1 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Complex regional pain syndrome (CRPS) type I

Contacts and locations

Locations

  • CH Saint-Quentin

    Saint-Quentin, 02321, France

  • CHU Amiens

    Amiens, 80054, France

  • CHU Rouen

    Rouen, 76031, France