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Stress and pain: scientists uncover hidden gene changes in fibromyalgia

NCT ID NCT06475859

Knowledge-focused Sponsor: Vrije Universiteit Brussel Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looked at how stress changes gene activity in women with chronic widespread pain (fibromyalgia). Researchers compared 84 women with and without the condition, using mental stress tests and relaxation breathing. They measured changes in DNA methylation, a process that can turn genes on or off. The goal was to understand why stress makes pain worse, which could lead to better treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could point toward new ways to understand and eventually treat stress intolerance in chronic pain conditions.
What could go wrong
This is an observational study with only 84 participants. It looks at biological markers, not a treatment, so it may not lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

84 people

The number who actually took part.

Started

Apr 2023

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Potential study participants will be recruited mainly through online advertisements, but also in hospitals.

Ages

18 to 70 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * female * age between 18 and 70 years old * body mass index (BMI) below 30 * inactive lifestyle * for patients only: received the diagnosis of fibromyalgia Exclusion Criteria: * other neurological, endocrine, cardiac, or systemic syndromes * history of cancer or heart failure * women that are pregnant or within one year after pregnancy

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Conditions

The condition(s) this trial relates to.

Chronic Pain fibromyalgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic widespread pain

Contacts and locations

Locations

  • Vrije Universiteit Brussel - UZ Brussel

    Brussels, Brussels Capital, 1050, Belgium

More trials for these conditions

Other studies related to the condition(s) this trial covers.