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Teens' chronic pain linked to stress hormones and brain changes, study finds

NCT ID NCT04488757

Knowledge-focused Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looks at how stress affects the brain and body in 70 teenagers (ages 11-17) with chronic widespread pain. Participants will have an MRI scan while experiencing mild heat pain, and provide saliva samples to measure stress hormones. The goal is to understand the link between stress, brain function, and pain, which could lead to better treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal how stress contributes to chronic pain in young people, pointing toward new ways to treat or manage the condition.
What could go wrong
This is an observational study, not a treatment trial. It is small (70 participants) and early-stage, so findings may not apply to everyone or lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2021

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

11 to 17 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Chronic Widespread Pain (CWP) group: Inclusion Criteria: * Between ages 11-17 years * Referred to the Boston Children's Hospital Pain Treatment Service for evaluation of a CWP condition with duration \> 3 months * Right-handed Exclusion Criteria: * Inability to speak sufficient English to complete questionnaires * Severe cognitive impairment * Prescription steroidal (interference with cortisol measures) or psychotropic medication * Any other chronic pain diagnosis (e.g., migraines, abdominal pain, CRPS) * fMRI contraindications (e.g., dental appliances) Healthy Control (HC) group: Inclusion Criteria: * Between ages 11-17 years * Right-handed Exclusion Criteria: * Inability to speak sufficient English to complete questionnaires * Severe cognitive impairment * Prescription steroidal (interference with cortisol measures) or psychotropic medication * Any chronic pain diagnosis * Presence of documented chronic (\> 3 months) medical condition with an identifiable, organic cause (e.g., diabetes, cystic fibrosis) * fMRI contraindications (e.g., dental appliances)

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Conditions

The condition(s) this trial relates to.

Chronic Pain fibromyalgia Stress, Psychological

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic widespread pain Stress, physiological Stress, psychological

Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.