Back surgery pain mystery: study hunts for clues

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria For All Participants: * Ability to read and speak English to allow for written informed consent, phenotyping, and patient-reported outcomes measures Exclusion Criteria For All Participants: * Individuals receiving or applying for compensation or disability and other aspects associated with potential secondary gain * Inability to provide written informed consent * Severe physical impairment * Co-morbid medical conditions that may significantly impair physical functional status * Illicit drug or unreported opioid use * Medical or psychiatric conditions that in the judgment of study personnel would preclude participation in this study * Pregnant or nursing * Liver failure * Self-reported liver cirrhosis * Self-reported hepatitis * Severe Cardiovascular disease Inclusion Criteria for Candidates for Lumbar Spine Surgery: * Deemed to be a candidate for primary lumbar spine surgery including but not limited to: lumbar laminectomy, discectomy, and fusion/instrumentation * Diagnostic clinical and radiographic findings including but not limited to: lumbar degenerative disc disease, lumbar disc protrusion, herniation, or extrusion, lumbar spondylosis, lumbar spinal stenosis, lumbar spondylolisthesis or spondylolysis * Willingness to participate in longitudinal follow-up or 6-months after their surgery. Exclusion Criteria for Candidates for Lumbar Spine Surgery: * History of previous lumbar spine surgery * Indication for lumbar spine surgery is due to spinal cancer-related diagnosis * Need for urgent or emergent lumbar spine surgery Inclusion Criteria for Candidates with Lumbar Failed Back Surgery Syndrome: * Chronic low back pain (+/- leg pain) for \>= to 6 months duration after lumbar spine surgery (with or without instrumented fusion) * Low back pain severity is moderate to severe (Numerical Rating Scale \[NRS\] Score \>=4) Exclusion Criteria for Candidates with Lumbar Failed Back Surgery Syndrome: * Have a structural spinal lesion that would make them a current candidate for a revision lumbar spine surgery Inclusion Criteria for Healthy Volunteers: * No major diseases or diagnoses influencing pain or function Exclusion Criteria for Healthy Volunteers: * No chronic pain condition * Score 3 or greater on the 2011 FM Survey Criteria (i.e. individuals with very mild fatigue or sleep problems will be allowed to participate as this is extremely common in the general population)