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Acupuncture with a jolt: new hope for shingles nerve pain?

NCT ID NCT04560361

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 11, 2026 · Updated 3 times

Summary

This completed trial tested whether electroacupuncture (acupuncture with a mild electric current) can reduce pain in people with postherpetic neuralgia, a lingering nerve pain after shingles. 448 adults aged 45-75 with moderate-to-severe pain were randomly assigned to real or sham electroacupuncture. The main goal was to see if pain scores dropped by at least 30%.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
electroacupuncture
What this could lead to
If it works, this could offer a non-drug option for managing nerve pain after shingles.
What could go wrong
The trial is completed but results are not yet widely confirmed. Sham acupuncture may also provide some relief, making it hard to know the true effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

448 people

The number who actually took part.

Started

Oct 2020

Finished

Sep 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who meet the diagnostic criteria for postherpetic neuralgia (with a clear history of acute herpes zoster, and the duration of postherpetic pain exceeds 90 days) * Aged 45 to 75 years old * Patients who were diagnosed with moderate or above pain during the observation period (the daily pain score was continuously collected within 7 days during the observation period, and the average NRS-11 pain score was \>=4) * Subjects who did not participate in other ongoing clinical studies * Sign informed consent and volunteer to participate in the study Exclusion Criteria: * Patients who are currently receiving or receiving more than one of the "permitted combinations" or any "prohibited combination and treatment" for PHN listed in the following part at least 14 days before screening, and are unwilling to undergo washout period, or patients with serious safety problems during washout period or observation period * Patients who are expected to receive any new prescription drug or other treatment for PHN after the start of the trial * Patients with serious uncontrolled medical conditions, such as cardiovascular, lung, liver, kidney, gastrointestinal tract, metabolism, endocrine, nervous system, respiratory system, urogenital system and other serious diseases, or systemic organ dysfunction, malignant tumor, hematologic disease such as bleeding tendency or coagulation dysfunction, serious mental illness such as depression or schizophrenia Symptoms, hepatitis B antigen or hepatitis C antibody positive known state or history of immune dysfunction, history of HIV infection, etc. * Patients with severe pain unrelated to PHN, such as after surgery for clinical major diseases * Patients with PHN who have received nerve intervention or other neurosurgical treatment, such as selective nerve damage, percutaneous radiofrequency thermocoagulation or pulsed nerve modulation technology, etc. * Patients with some special types of herpes zoster, such as those with meninges, cornea, conjunctiva, ear involvement, visceral herpes zoster, generalized herpes zoster * Patients with skin ulceration, new herpes, or skin infection * Patients with cardiac pacemaker, metal allergy or severe fear of needle * Patients who are unable to give full informed consent or cannot cooperate with pain scale assessment due to mental, mental, linguistic or behavioral disorders * Patients who have poor compliance or are prone to fall off due to other reasons, such as the current residence is not in the city where the recruitment hospital is located, or the working environment changes frequently * Pregnant and lactating women

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Conditions

The condition(s) this trial relates to.

Neuralgia, Postherpetic postherpetic neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Huai'an Hospital of Traditional Chinese Medicine

    Huai'an, Jiangsu, 223001, China

  • Jiangsu Province Hospital of Chinese Medicine

    Nanjing, Jiangsu, 210029, China

  • Lianyungang Hospital of Traditional Chinese Medicine

    Lianyungang, Jiangsu, 222004, China

  • Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine

    Nanjing, Jiangsu, 210001, China

  • Nantong Hospital of Traditional Chinese Medicine

    Nantong, Jiangsu, 226001, China

  • Shuyang Hospital of Traditional Chinese Medicine

    Suqian, Jiangsu, 223600, China

  • Wuxi Hospital of Traditional Chinese Medicine

    Wuxi, Jiangsu, 214071, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.