Could a simple mineral calm the stress of fibromyalgia?
NCT ID NCT03887000
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This trial tests whether taking magnesium can reduce stress in people with fibromyalgia, a condition marked by widespread pain and fatigue. Participants will be randomly assigned to receive magnesium or a placebo, and researchers will measure stress levels along with pain, sleep, and quality of life. The goal is to see if this mineral could be a helpful addition to managing the condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- magnesium
- What this could lead to
- If magnesium helps, it could offer a simple, low-cost way to reduce stress and improve quality of life for people with fibromyalgia.
- What could go wrong
- This is a small early-stage trial, and magnesium may not outperform placebo. Results will need confirmation in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
75 people
The number who actually took part.
- Started
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Mar 2019
- Finished
-
May 2020
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient over the age of 18, * Patient with fibromyalgia according to the criteria of the 2016 ACR, * Patient presenting a score on the DASS-42 \> 18 scale, * Patient free from any initiation of new treatment or diet at the time of inclusion, * Cooperation and understanding sufficient to comply with the requirements of the study, * Acceptance to give written consent, * Affiliation to the French Social Security system, * Registration or acceptance of registration in the National Register of Volunteers participating in research. Exclusion Criteria: * having a contraindication to the administration of magnesium: hypersensitivity to magnesium chloride, or to any of the excipients, * with a magnesium concentration of \> 1.05 mmol / l,- with severe renal impairment with a creatinine clearance \< 30 ml / min, * receiving a treatment or dietary supplement containing magnesium at the time of inclusion, * treated with antibiotics in the three months prior to inclusion,- who has reported gastroenteritis in the two months prior to inclusion, * physically unfit to place the palms or soles of the feet on the Sudoscan® electrodes, * having a medical and / or surgical history judged by the investigator or his representative to be incompatible with the test (in particular a disease known to cause small fiber neuropathies: diabetes, Sjögren's disease, vasculitis, sarcoidosis, chronic ethylism ....), * using anticoagulant therapy or allergy to local anesthetics,- of childbearing age not using an effective contraceptive method, pregnant or breastfeeding woman. * participating in another clinical trial, or being in the exclusion period, or having received a total amount of benefits exceeding EUR 4500 over the 12 months preceding the start of the trial, * having cooperation and understanding that does not allow strict compliance with the conditions laid down in the Protocol, * benefiting from a measure of legal protection (guardianship, guardianship, deprivation of liberty, safeguard of justice), * not affiliated to the French Social Security system.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Chu Clermont-Ferrand
Clermont-Ferrand, 63003, France
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Other studies related to the condition(s) this trial covers.
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