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Brain scans reveal hidden inflammation in chronic back pain sufferers

NCT ID NCT03106740

Knowledge-focused Sponsor: Marco Loggia Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study used special brain scans to look for signs of inflammation in the brains and spinal cords of 60 people with chronic low back pain. Researchers also tested whether a short course of the antibiotic minocycline could reduce both inflammation and pain. The goal was to better understand the role of brain inflammation in chronic pain and explore a potential new treatment approach.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

60 people

The number who actually took part.

Started

Oct 2017

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * the ability to give written informed consent * fluency in English * on a stable pain treatment * Chronic or sub-acute low back pain Exclusion Criteria: * no interventional pain procedures during drug trial * contraindications to MRI and PET scanning (including presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia) * pregnancy or breast feeding * any use of recreational drugs in the past 6 months * allergy to minocycline or other tetracyclines, or taking medications known to interact with minocycline * any other contraindications to minocycline administration

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Conditions

The condition(s) this trial relates to.

Back Pain Chronic Pain chronic pain syndrome cyclopia sequence Low Back Pain Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Back ache Back pain lower back chronic Back pain with radiation Back pain without radiation Low back pain Pain, chronic

Contacts and locations

Locations

  • Massachusetts General Hospital

    Charlestown, Massachusetts, 02129, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.