Obesity disorder

This study tests a new medicine, maridebart cafraglutide, for adults with obstructive sleep apnea who are overweight or obese and already use a CPAP machine. The goal is to see if the drug can reduce breathing pauses during sleep and help with weight loss over 52 weeks. About 250…

This study tests a new drug called maridebart cafraglutide to help adults with obesity or overweight lose weight. About 3853 people will take either the drug or a placebo for 72 weeks. The main goal is to see how much weight they lose and if it is safe.

This study tests a new medicine called NNC0662-0419 in 230 adults with obesity (BMI 30 or higher). Researchers want to see if different ways of increasing the dose over time can reduce stomach side effects while still helping people lose at least 25% of their body weight. The stu…

Researchers at Stanford University are testing whether a program that combines weekly healthy food deliveries with group lifestyle coaching helps Latino patients with type 2 diabetes. The study enrolls adults who receive care at partner clinics, have type 2 diabetes, and report f…

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, for weight loss in adults with overweight or obesity. About 872 participants will receive either the drugs or a placebo injection. The main goal is to see how much weight they lose over…

This study tests a new, personalized version of a weight-loss surgery called SADI-S. Surgeons will measure each patient's small intestine and adjust the bypass length to maximize weight loss while lowering the risk of vitamin deficiencies. The study includes 40 adults with obesit…

This study tests whether a new medicine called NNC0487-0111, given as a weekly injection, is safe and effective for weight loss in adults with obesity. About 600 participants will receive either the active drug or a placebo (dummy injection) for comparison. The main goal is to me…

This study tests an experimental drug called BI 3034701 to help people with obesity or overweight lose weight. About 300 adults aged 18-74 will receive either the drug or a placebo injection for 42 weeks, along with diet and exercise advice. Researchers will measure weight change…

Researchers are studying how the length of bypassed intestine during gastric bypass affects weight loss, complications, and metabolic changes in people with severe obesity. Participants will have different lengths of intestine bypassed and will provide blood and stool samples bef…

This study compares the experimental drug CagriSema (cagrilintide and semaglutide) to a calorie-reduced diet in 80 adults with obesity. It measures how each approach changes the body's energy use, like sleeping metabolic rate. The study lasts about 1.5 years, and all participants…

Researchers compare a very low calorie ketogenic diet with a Mediterranean-style low-calorie diet in 40 adults who have type 2 diabetes, obesity, and non-alcoholic fatty liver disease. Participants follow one of the two diets for several weeks. The study measures changes in weigh…

Researchers are testing whether high-intensity interval training (HIIT) helps overweight and obese adults improve physical activity, waist-to-hip ratio, sleep quality, self-esteem, stress, and motivation. The trial compares two ways of doing HIIT: online sessions supervised by a …

This study tests an experimental drug called BGE-102 in 160 adults with obesity and heart risk factors. The goal is to see if it lowers inflammation (measured by hsCRP) safely. Participants take either BGE-102 or a placebo daily for 12 weeks.

This early-stage study tests an experimental oral drug called RO7795081 in 40 healthy overweight or obese adults. The main goals are to check safety and how the drug interacts with common statins (rosuvastatin and pitavastatin). Participants will receive the drug or a placebo in …

This study is testing whether two different versions of the drug survodutide are equally effective in the body. It involves 80 healthy overweight or obese adults who will receive both formulations in a crossover design. The goal is to see if the new formulation matches the origin…

This pilot study tests a new approach to childhood obesity treatment: before starting a 12-week family weight management program, families work with a community health worker for three months to address social needs like food, housing, or healthcare access. The study enrolls 120 …

This study tests whether a once-weekly injection of semaglutide helps children and teenagers (ages 6 to 17) with obesity or overweight lose weight. About 210 participants will receive either the drug or a placebo for up to 2.5 years, along with healthy lifestyle counseling. The m…

This study tests whether an online weight management program for child care providers can improve the diet and physical activity of 2-5-year-old children in their care. About 84 child care centers and 924 participants (directors, teachers, and children) will take part. Some cente…

This early-stage trial is testing a new drug called AMG 513 in 80 adults with obesity. The main goal is to see if the drug is safe and how the body handles it. Participants will receive either the drug or a placebo by injection, and researchers will monitor for side effects and m…

This study tests an experimental oral medication, KAI-7535, taken once daily to help people with obesity or overweight lose weight. About 320 adults with at least one weight-related condition (like high blood pressure or sleep apnea) will receive either the drug or a placebo for …

This study tests whether adding an experimental drug (RO7204239) to an existing weight-loss medication (tirzepatide) helps adults with obesity or overweight lose more weight over 48 weeks. About 285 participants without diabetes will receive either the combination or a placebo pl…

This Phase 3 trial tests a new medicine called MET097, given as a weekly injection, to help adults with overweight or obesity and type 2 diabetes lose weight. About 999 people will take part, with two-thirds getting the real drug and one-third getting a placebo. The study lasts a…

This study looks at whether drinking water before meals helps people aged 50 and older with overweight or obesity lose weight. 375 participants will be split into three groups: one drinks water before each meal, one drinks water throughout the day, and one follows a diet without …

This study tests a new medicine called cagrilintide to help people who are overweight or have obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to see how much weight they lose and how …

This Phase 2b trial tests whether adding enobosarm (a muscle-preserving drug) to semaglutide (a weight-loss drug) helps older adults lose more fat and keep muscle. About 200 people aged 65 and older who are overweight or obese will take both drugs or semaglutide alone. The goal i…

This large phase 3 trial is testing a new once-weekly injection called MET097 for weight loss in 3501 adults with obesity or overweight (but without diabetes). Participants will receive either the drug or a placebo for up to 84 weeks. The main goal is to see how much weight peopl…

This phase 2 trial tests whether MWN109 tablets can help non-diabetic adults with overweight or obesity maintain weight loss over 24 weeks. Participants who already lost at least 5% of their body weight in a prior study will take the tablet either once daily or once weekly. Resea…

This study compares three treatments for severe obesity: two types of bariatric surgery (gastric bypass and sleeve gastrectomy) and two newer weekly injectable medications (semaglutide and tirzepatide). About 125 adults with a BMI of 35 or higher will be followed for one year to …

This trial tests whether nutrition counseling delivered over video calls can help people with spinal cord injury eat healthier and lower their risk of obesity, high cholesterol, and diabetes. Participants, who are at least one year post-injury and overweight, will receive six ses…

This Phase 2 trial tests two experimental drugs, trevogrumab and garetosmab, added to the weight-loss drug semaglutide (Wegovy) in about 1,000 people with obesity. The goal is to see if the combination improves weight loss and body composition (more fat loss, less muscle loss) co…

This study tests whether a gentle electrical current applied to a brain area involved in fullness can reduce food intake and promote weight loss. Over 4 weeks, 148 obese adults will receive either real or fake stimulation while following a reduced-calorie diet. The goal is to see…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, type 2 diabetes, or high blood pressure. Participants use a tablet, scale, and activity tracker at home, and some get extra support from a co…

This Phase 3 study tests a once-weekly injection called CagriSema, which combines two drugs (cagrilintide and semaglutide), to help people with overweight or obesity lose weight. About 3,400 adults will receive either CagriSema, one of the drugs alone, or a placebo for 1.5 years,…

This trial tests whether eating a cup of black beans or chickpeas every day for 12 weeks can reduce inflammation and improve insulin sensitivity in adults who are overweight or have elevated blood sugar. Participants are randomly assigned to eat beans, chickpeas, or rice as a con…

This study follows overweight and obese adults aged 45-65 to see if a tailored program of counseling, supervised exercise, and digital tools helps them lose weight and improve heart health over 18 months. Participants are compared to a group that only gets general written advice.…

This trial tests whether MWN109, an investigational injection, can help non-diabetic adults with overweight or obesity lose weight. About 125 participants will receive either MWN109 or a placebo once a week for 36 weeks. The main goal is to see how much body weight changes from t…

This study tests whether using a handheld breathing trainer for a few minutes each day can lower blood pressure in adults with obesity. Researchers will compare high-resistance versus very-low-resistance breathing exercises over eight weeks. The goal is to find a time-efficient w…

This study tests a new drug combination (AZD9550 and AZD6234) for weight loss in 166 adults who are overweight or obese, with or without type 2 diabetes. The main goals are to check safety, tolerability, and how the drug moves through the body. It is an early-stage trial, so it f…

This trial tests four different video laryngoscopes to see which one works best for placing a breathing tube in severely obese patients undergoing weight-loss surgery. About 100 adults will take part, and the study will measure how often the tube is placed successfully on the fir…

This study compares an intensive weight loss program—including meal replacements, behavioral support, and weight-loss medication—against standard care for adults with severe and complex obesity. The goal is to see if the intensive approach leads to better health outcomes and is c…

This study tests whether tirzepatide, a drug approved for weight management, can help people who are obese and have a moderate to severe stimulant use disorder (like methamphetamine or cocaine). Participants receive weekly injections for 20 weeks, along with counseling and brain …

This study tests tirzepatide, a once-weekly injection, in 344 Indian adults with type 2 diabetes or obesity. Over 46 weeks, researchers will check for serious side effects and measure weight loss and blood sugar control. The goal is to see if this drug is safe and effective for t…

This trial tests whether a newer surgical technique, which combines sleeve gastrectomy with a rerouting of the digestive tract, can control acid reflux as well as the standard gastric bypass in adults with obesity. The new approach aims to keep the entire digestive tract visible …

This study tests a new daily pill, orforglipron, to help adults with obesity or overweight who also have weight-related conditions like high blood pressure or sleep apnea lose weight. About 3,100 participants will take either the pill or a placebo for 72 weeks, with some continui…

This pilot study tests whether a daily probiotic supplement containing L. acidophilus (strain TW01), originally isolated from fermented coffee grounds, can improve gut health, body composition, and markers of inflammation. Overweight or obese adults aged 18-60 will take either th…

This study looks at whether eating only during a set window each day combined with short, intense exercise can help overweight adults lose fat and improve health markers like blood sugar and cholesterol. One hundred participants will follow this routine remotely for 12 months, wi…

This study tests whether offering personalized financial incentives can help 80 adults with obesity stick to a weight-loss program. Participants attend virtual group classes, log their calories, and weigh themselves regularly. The goal is to see if tailored rewards improve diet t…

This study looks at whether game-like features and social rewards can help overweight veterans with high blood pressure become more physically active. About 725 veterans will take part in a 9-month program where they either compete or cooperate to increase their daily steps. The …

This study tests a program that teaches parents how to help their child, a childhood cancer survivor, eat healthy and exercise more. The goal is to prevent or reduce obesity, which is a major risk for heart disease in these children. About 520 families will take part in one of tw…

This pilot trial tests whether the timing of carbohydrates and protein across meals can improve glucose metabolism in people with prediabetes or type 2 diabetes who are overweight or obese. Participants follow two different isocaloric diets—one with a high-protein breakfast and h…

This study tests an experimental drug called CS060380, taken with the weight-loss drug semaglutide, in adults with both fatty liver disease (MASH) and obesity. About 120 participants will be randomly assigned to get either CS060380 or a placebo for 36 weeks, then everyone gets CS…

This early-stage study tests a new daily pill, RO7795081, in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body handles it. Participants will receive either the drug or a placebo, and researchers will monitor…

This trial tests whether adding self-monitoring of breath acetone—a marker of fat burning—to an app-based lifestyle program helps overweight adults lose more weight. Participants will use the LIM-App for 12 months and report their weight. The study compares those who also monitor…

This Phase 3 trial tests whether cagrilintide, a new injectable drug, helps people with overweight or obesity lose weight. About 300 adults will receive either cagrilintide or a placebo for up to 18 months, along with lifestyle counseling. The study measures weight change and wai…

This study tests whether a brief, personalized online tool (MyHealthPath) can increase the number of adults with obesity who start a comprehensive behavioral weight loss program. Participants will be randomly assigned to receive either the tailored tool or informational material.…

This two-year study will follow 1,250 people with obesity who are starting Wegovy (semaglutide) as part of their regular medical care. Researchers will track changes in weight, waist size, and quality of life to see how the drug performs outside of clinical trials. The goal is to…

This pilot trial tests whether tirzepatide, a drug used for diabetes and weight loss, can help people who still have obesity one year after gastric bypass surgery. Thirty participants will either receive the drug or standard care. The study tracks weight changes and any stomach-r…

This study tests a weekly oral medication called ecnoglutide (VRB-101) to see if it can help people with obesity or overweight maintain their weight. Participants must have already been on weekly injections of semaglutide or tirzepatide for at least 6 months. The goal is to find …

This trial tests whether a nutritional supplement, designed with the help of artificial intelligence to target the gut microbiome, can help adults with overweight or obesity lose weight. Eighty participants will receive either the active supplement or a placebo for 24 weeks, alon…

This early-stage trial tests an experimental drug called SYH2069, given as an injection under the skin, in healthy volunteers. The goal is to see if it is safe and how the body processes it at different doses. The study includes people who are overweight or obese, as the drug is …

This study tested whether adding stress management techniques to a standard weight loss program helps Black women with obesity lose more weight. Over 300 women with high stress levels took part. The goal was to see if a culturally-tailored approach could improve weight loss resul…

This Phase 1 trial tests whether a single dose of an experimental drug called SYH2082 is safe and tolerable in healthy adults aged 18 to 55 who are overweight or have obesity. Participants receive either the drug or a placebo injection, and researchers monitor for side effects an…

This early study tests a brain implant that monitors and stimulates brain activity to reduce loss-of-control eating in people with severe obesity who haven't been helped by other treatments. Only 6 participants will receive the device, and the main goal is to check safety and see…

This study tests a web-based tool called the BMI-CDS (Weight Loss Wizard) in 40 primary care clinics. The tool gives doctors and patients with type 2 diabetes and obesity personalized estimates of the benefits and risks of treatments like weight-loss surgery or medication. Over 1…

This trial tests whether 16 weeks of supervised exercise, with or without daily taurine supplements, can reduce fat stored inside the muscles of women aged 60–75 with obesity. Researchers will use MRI scans, muscle biopsies, and blood tests to measure changes in muscle compositio…

This study tests whether a home-visit program called PAT+HEALTH can help pregnant women with obesity in Nigeria improve their heart health and manage weight. About 1,000 women will be randomly assigned to receive the program or standard care. Researchers will track weight, lifest…

This phase 2 trial tests the drug setmelanotide in one person with pseudohypoparathyroidism type 1a (PHP1a), a rare genetic disorder that often causes severe obesity. The participant will receive daily injections of setmelanotide for six months to see if it leads to weight loss a…

This study investigates whether tirzepatide, a drug used for diabetes and weight loss, can reverse biological aging in people with HIV who are virally suppressed and have obesity. Participants receive tirzepatide for 25 weeks after a diet program. Researchers measure epigenetic a…

This phase 3 trial tests whether retatrutide is better than tirzepatide for weight loss in 800 adults with obesity. Participants receive one of the two drugs for about 89 weeks. The study measures changes in body weight, BMI, waist size, and other health markers.

This study tests whether using a pedal-assist electric bike for commuting can improve physical activity, fitness, and health in overweight or obese college students. Participants are randomly assigned to either use an e-bike for at least four trips per week for 12 weeks or to a c…

This study investigates whether GLP-1 receptor agonists (semaglutide or tirzepatide), combined with diet and exercise, can improve physical function, reduce biological aging, and enhance vascular health in postmenopausal women with obesity. Participants will take the medication a…

This study tests whether semaglutide, a drug already used for obesity and type 2 diabetes, can reduce liver scarring in people with non-alcoholic fatty liver disease (NAFLD). Participants are adults aged 40 to 80 who are overweight or have type 2 diabetes. The trial will also val…

This study investigates whether adding two common drugs—valsartan (for high blood pressure) and celecoxib (for arthritis pain)—to standard metformin therapy can improve blood sugar control in people with type 2 diabetes. The trial enrolls adults with obesity, high blood pressure,…

This early-stage trial is testing a new drug called brenipatide in 150 healthy people with overweight or obesity. Participants receive different doses of the drug or a placebo as injections under the skin. The study lasts about 42 weeks and aims to see how well the drug works for…

This study tests a new medicine called KAI-9531 (ribupatide) given as a weekly shot to help people with obesity lose weight. It includes 250 adults who have a BMI of 35 or higher and have tried to lose weight before without success. Participants will receive either the drug or a …

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This trial tests a culturally adapted program called Health Without Barriers/Salud Sin Barreras for teens aged 11–19 and their families in Northern Colorado. The program combines mindfulness, nutrition education, physical activity, and parenting support over several sessions. Res…

This study looks at whether a GLP-1 receptor agonist, a drug already used for diabetes and obesity, can improve fat buildup in the liver and blood in people with MASLD. Researchers will measure changes in fats, proteins, and genes in 30 participants who already take the drug. The…

This study looks at whether weight-loss surgery (sleeve gastrectomy) combined with lifestyle changes, or lifestyle changes alone, can help women who have had early-stage breast cancer and are obese. The goal is to see if losing weight might lower the chance of the cancer returnin…

This study tests whether a culturally tailored plant-based diet, guided by community health workers, can help Latino adults with obesity lose weight and improve metabolic health. Forty participants will be randomly assigned to either the plant-based diet program or standard healt…

This study tests whether virtual group visits—where patients meet online for diabetes education, support, and goal setting—can improve blood sugar control in people with type 2 diabetes who also have heart-related conditions. About 720 adults from participating clinics will take …

This study is testing different combinations of diet and exercise to find the best weight loss plan for people with prediabetes who also have physical or mobility disabilities. Thirty participants will start with either a high or reduced carbohydrate diet. After four weeks, those…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This study tests a procedure that reroutes part of the small intestine to help control type 2 diabetes and weight. About 15 adults with diabetes and obesity will be followed for a year to see if their blood sugar and weight improve. The goal is to reduce the need for diabetes med…

This study tests a program called SANOS that teaches Mexican adults how to eat healthy without spending a lot of money and how to be more active. About 1,785 overweight or obese participants will receive counseling and be followed for up to a year. The goal is to see if this appr…

This pilot study tests whether personalized herbal medicine can help obese adults with spinal or joint pain lose weight and reduce pain. Forty participants will receive either herbal treatment plus lifestyle guidance or lifestyle guidance alone. The study measures changes in BMI …

This trial tests whether an immersive virtual reality exercise program, done three times a week during school breaks, can improve body composition and fitness in children aged 12 to 16 with overweight or obesity. Participants wear a head-mounted display and play active video game…

This study tests three home-based programs—healthy eating, physical activity, and gardening—designed to prevent obesity in Hispanic children aged 3 to 4 living in rural West Texas. Over 24 months, researchers will measure changes in body mass index, waist-to-height ratio, and bod…

This study tests whether tirzepatide, a once-weekly injection, helps teenagers with obesity or overweight (with related health issues) lose weight. About 160 teens will receive either tirzepatide or a placebo for 72 weeks, alongside lifestyle advice. The main goal is to see if bo…

This study tests whether adding an AI chatbot to a 12-week smartphone weight loss program helps young adults with overweight or obesity lose more weight and stay engaged. Twenty participants will either get the standard program or the program plus a chatbot for extra support. Res…

This Phase 2a trial tests whether adding an oral drug called ECC4703 to the weekly injection semaglutide helps adults with obesity lose more weight and reduce liver fat. About 151 participants will take either ECC4703 or a placebo alongside semaglutide for 20 weeks. The study is …

This study tests a new procedure called BEAM (Bariatric Endoscopic Antral Myotomy) to help people with obesity lose weight. The procedure uses a tube down the throat to make small cuts in the stomach muscle, aiming to change how the stomach empties. Twenty adults with a BMI betwe…

This study tests a 4-month program called GOAL that helps 5th-8th graders eat healthier and be more active. It includes after-school clubs, parent meetings, and a website. About 935 teens and their parents from Michigan schools are taking part. The goal is to lower heart disease …

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose monitor and, if in the intervention group, used …

This study tests a new drug, olatorepatide, for weight loss in people who are overweight or obese but do not have diabetes. The drug works by targeting hormones that control appetite and blood sugar. Researchers will check how safe the drug is, how the body processes it, and how …

This study looks at whether sewing shut a specific incision site (the epigastric trocar) during sleeve gastrectomy can prevent hernias from forming later. People having their first sleeve gastrectomy for obesity are included, while those with prior stomach banding or repeat sleev…

This study tests whether a stepped-care program using digital tools like smart scales, activity trackers, and text messages, plus in-person counseling if needed, can help adults with obesity maintain at least 5% weight loss for a year. About 258 participants first lose weight thr…

This study aimed to see if blocking blood vessels to part of the stomach (bariatric embolization) could help super obese patients lose weight before sleeve gastrectomy surgery, potentially lowering surgical risks. It planned to enroll patients with a BMI over 50 and at least thre…

This study tests whether adding a specially trained doula, along with home blood pressure and weight monitoring, can improve blood pressure in women who had high blood pressure during pregnancy. About 454 women will be randomly assigned to usual care or the doula program. The goa…

This study looks at whether adding Traditional Chinese Medicine (TCM) to standard weight-loss drugs helps people lose more weight. About 296 adults with obesity (BMI 27 or higher) in Taiwan are being followed for 6 to 12 months. Researchers are measuring weight loss, body fat, an…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study compares two digital weight loss programs for people with obesity. One program uses weekly live video meetings, while the other uses a private Facebook group that participants can access anytime. The goal is to see if the flexible, on-demand option works as well as the…

This study looks at whether adding a combination of two drugs (naltrexone and bupropion) or a behavioral weight-loss program can help people who didn't lose enough weight after bariatric surgery. About 84 participants will receive either the drugs, behavioral therapy, both, or a …

This study looks at whether taking a synbiotic supplement (a mix of probiotics and prebiotics) and eating more fruits and vegetables can lower the risk of obesity and related health problems in Hong Kong Chinese adults. One hundred overweight or obese participants will follow the…

This phase 3 trial is testing different ways to increase the dose of retatrutide, a new weight-loss drug, in 600 people with obesity or overweight who do not have type 2 diabetes. The study lasts about 113 weeks and measures weight loss, waist size, and other health markers. The …

This study looks at whether the diabetes drug metformin, combined with a low-calorie diet, helps overweight or obese adults with a large waistline lose weight. About 150 participants will take either metformin or a placebo for 24 weeks. The main goal is to see if at least 5% of b…

This study tests an online weight loss program for couples. It includes 762 married or cohabitating partners who are overweight or obese. The program adds four strategies—like joint goal setting and partner feedback—to a core behavioral weight loss plan. The goal is to see which …

This study tests a 3-month lifestyle program called the PILI Pasifika Program for Native Hawaiian and Pacific Islander adults who are overweight or have conditions like high blood pressure or diabetes. The program includes group lessons on healthy eating and physical activity, pl…

This study tests a family-based program called LEADS for overweight African American teens and their parents. The program teaches stress-coping skills, mindfulness, and positive parenting to help teens become more physically active. Researchers will measure changes in daily exerc…

This study tests whether using a connected scale at home can help people who had bariatric surgery avoid regaining too much weight. About 182 adults who had surgery one year ago will either get standard follow-up or also weigh themselves weekly with a smart scale. If the scale sh…

This study tests a telehealth program for Latino families with children aged 5 to 12 who have overweight or obesity. The program helps caregivers support healthy changes, and is compared to standard health education. The goal is to see if this approach improves children's weight …

This study looks at whether children and teens being treated for acute lymphoblastic leukemia can follow a low-glycemic (low-sugar) diet for six months. The goal is to see if this diet is practical and helps manage weight during cancer treatment. About 88 participants will track …

This study tests a new drug called MET097, given as a shot, to help people with obesity or overweight lose weight. After 12 weekly doses, participants switch to monthly shots for up to 64 weeks. The trial compares four different dose schedules against a placebo to see which works…

This study tests a new drug called CRB-913 for weight loss in people with obesity. It involves 252 participants and has two parts: first, measuring how the drug works in healthy adults, then comparing three doses against a placebo over 12 weeks. The goal is to check safety and ho…

This study looks at whether taking a yerba mate extract can help improve health markers in overweight adults. Eighty people aged 40-65 will take either the extract or a placebo for 90 days. Researchers will measure changes in weight, blood sugar, cholesterol, and inflammation to …

This study tests a health support program for 600 people with disabilities who also have chronic conditions like diabetes or obesity. The program includes weekly nutrition classes, three exercise sessions per week, and help managing chronic conditions. Researchers want to see if …

This study looks at a 12-week program called 'GameDay Ready' to help Black men living in rural South Carolina lose weight. About 29 men will take part, and their weight changes will be compared to a group that does walking and general health education. The goal is to see if the n…

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This study was designed to see if a dietary supplement called WM Formula could help people with obesity lose weight and improve blood sugar and fat levels. It planned to enroll adults with high body fat who were not taking weight-loss or diabetes drugs. However, the study was wit…

This study tests whether whole-body electromyostimulation (WB-EMS), a technology that stimulates muscles with mild electrical pulses, can lower resting blood pressure and improve other heart risk factors in overweight adults aged 50+ with mild hypertension. Over 12 weeks, 28 part…

This study tests whether the drug liraglutide, combined with healthy lifestyle changes, can help children aged 6 to 12 with severe obesity lose weight and improve heart function. Thirty children will receive either liraglutide injections plus lifestyle advice or lifestyle advice …

This study tests whether a probiotic called Limosilactobacillus fermentum CRL 1446 can improve health in 80 adults with heart disease risk factors like obesity, high blood pressure, and high cholesterol. Participants take either the probiotic or a placebo daily, and researchers m…

This study tests whether a new weekly injection called IBI362 works better than the existing drug semaglutide for weight loss and reducing liver fat in overweight or obese Chinese adults with metabolic dysfunction-associated fatty liver disease (MAFLD). About 479 participants wil…

This study tests whether guiding people to use free online weight loss tools helps them lose weight. About 473 adults with obesity from primary care clinics will take part. One group gets extra support and motivation to use these tools, while the other group gets basic informatio…

This phase 3 trial tests tirzepatide, a once-weekly injection, in 905 adults with type 1 diabetes who are also overweight or obese. Participants will receive either tirzepatide or a placebo for about 49 weeks. The study measures changes in blood sugar control (HbA1c) and body wei…

This study tests a community-based program to help Black and Latino adults with diabetes, prediabetes, high blood pressure, or obesity. Participants receive lifestyle coaching, help connecting to health and social services, and digital skills training. The goal is to see if this …

This study looks at whether combining high-intensity interval training with recovery in low oxygen (hypoxia) and taurine supplements can improve body composition, metabolism, and mitochondrial function in women with obesity. Fifty women aged 25–45 with a BMI of 30–35 will exercis…

This study tests a new device called the Luso-Cor esophageal stent for closing leaks (fistulas) that can happen after weight-loss or cancer surgery on the stomach or esophagus. About 180 adults will be enrolled and their outcomes compared to those treated with standard stents or …

This study tests whether a structured high-protein diet with meal replacements helps adults with overweight or obesity lose more weight than a standard low-calorie diet. About 60 participants will follow a calorie-restricted plan and attend visits for body measurements and blood …

This study tests a smartphone-based weight loss program (EVO) against the standard Diabetes Prevention Program (DPP) in 524 adults with obesity. Participants use an app to track diet, activity, and weight, with remote coaching. The goal is to see which approach leads to more weig…

This study tests a 6-month home-based program called FIT Families, designed to help African American teens with obesity and their caregivers lose weight. The program includes coaching sessions, family counseling, and small prizes for completing tasks. Researchers will measure cha…

This pilot study explores how a 6-month low-carbohydrate diet affects blood sugar control, body composition, and gut-brain interactions in 40 obese adults with or without glucose intolerance or diabetes. Participants follow a low-carb eating plan, and researchers measure changes …

This study tracks 30 adults with obesity who are starting anti-obesity medications like Wegovy or Mounjaro. Researchers will measure how these drugs affect 24-hour energy expenditure and body composition (fat vs. muscle) over 6 months using a metabolic chamber and DXA scans. The …

This study tests whether semaglutide, a drug used for diabetes, can reduce harmful belly fat and improve heart health in people with HIV who have excess fat around the midsection (lipohypertrophy). About 108 participants will receive either semaglutide or a placebo for 32 weeks. …

This study uses brain scans (fMRI) to see how the weight-loss drug lorcaserin changes activity in brain areas that control appetite and food intake. Forty obese adults will receive either lorcaserin or a placebo pill. Researchers will also measure changes in body composition. The…

This study looks at how the weight-loss drug Saxenda (liraglutide) changes brain activity related to appetite. Researchers will scan the brains of 28 obese adults to see how they respond to food cues after treatment. The goal is to understand the underlying mechanisms that help p…

This study tests a telehealth program that teaches parents of children with autism and overweight or obesity how to help their child manage weight through nutrition, activity, and behavior skills. About 140 families will take part, with one group receiving the parent-based progra…

This study is testing a new digital weight management program for adults with obesity who are referred to NHS Tier 3 services. The program uses a smartphone app to help people manage their weight. Researchers want to see if it improves health, saves money, and works well for pati…

This study tests whether semaglutide (Wegovy), a weekly injection for weight loss, can help people in secure mental health care who have gained weight from antipsychotic drugs like clozapine or olanzapine. About 20 adults with a BMI of 35 or higher will receive the drug along wit…

This study tests a new daily pill, aleniglipron, in 58 adults with type 2 diabetes who are overweight or obese. The main goal is to check if the drug is safe and tolerable at different doses. Researchers will also measure weight loss and blood sugar changes. The study is not yet …

This study tests a 10-week program called Healthy Dads, Healthy Kids for Hispanic families in Houston. Dads aim to lose weight, while kids increase physical activity through group sessions and joint exercise. About 187 fathers and their children are taking part to see if the prog…

This study tests whether a diet with more protein (25% of daily calories) helps children aged 7-14 with overweight or obesity lose weight and reduce diabetes risk. Over 10 weeks at a lifestyle camp, one group eats a higher-protein diet while another eats a lower-protein diet, bot…

This study planned to test whether a virtual weight control program (WW, formerly Weight Watchers) could help adults with type 2 diabetes and obesity lower their blood sugar levels. Participants would have used the WW SmartPoints system and attended weekly online workshops. Howev…

This study follows 120 teenagers aged 13 to 18 with severe obesity to see if weight-loss surgery (gastric bypass) leads to better health than standard treatments like diet and exercise. Participants are tracked for up to 10 years, measuring weight loss, quality of life, and menta…

This study looks at whether a non-surgical stomach-reducing procedure called endoscopic sleeve gastroplasty (ESG) can help obese people with nonalcoholic fatty liver disease lose weight and improve liver health. Researchers will measure changes in liver fat and stiffness, as well…

This study tests whether a Mediterranean diet combined with intermittent fasting can reduce liver scarring (fibrosis) better than the weight-loss medication naltrexone/bupropion. About 70 adults with overweight or obesity and heart or metabolic risks (like type 2 diabetes or high…

This study tests whether group nutrition education based on Brazil's dietary guidelines can help overweight adults eat better and lose weight. Sixty participants will attend monthly group sessions or receive individual counseling. Researchers will compare diet quality, BMI, and w…

This study planned to test a procedure called bariatric embolization for people with morbid obesity who cannot have standard weight-loss surgery. The procedure involves injecting tiny particles into blood vessels near the stomach to reduce blood flow, which may lower hunger hormo…

This study tests a once-weekly injection called retatrutide to help people with obesity or overweight lose weight. About 250 participants without type 2 diabetes will receive either the drug or a placebo for 65 weeks. The main goal is to see how much weight they lose and if it is…

This study looks at whether adding a small bypass (gastroenteroanastomosis) to the standard sleeve gastrectomy can prevent or reduce acid reflux in people with obesity. Sixty patients will be split into two groups: one gets the added bypass, the other does not. Researchers will c…

This study tests whether semaglutide (Wegovy), a once-weekly injection, can preserve the pancreas's ability to produce insulin and reduce liver fat in 60 obese youth with prediabetes or early type 2 diabetes and fatty liver disease. Participants receive either semaglutide or a pl…

This study tests whether a new drug called XW003 works better than the existing drug semaglutide for weight loss in Chinese adults with obesity. About 163 participants with a BMI of 30 or higher will receive either drug, and researchers will measure changes in body weight, waist …

This study looked at whether time-restricted eating (eating only during a set window each day) helps overweight or obese people with prediabetes return to normal blood sugar levels. Over 12 months, 142 participants either followed this eating pattern or received standard care. Th…

This study tests a 6-month online weight loss program designed for Arab adults in Saudi Arabia. Participants are randomly assigned to either the online program or standard hospital-based dietary care. The online program includes 12 Arabic educational sessions and dietitian suppor…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits and infections. About 49 adults who had a kidney transplant in the past 2–12 months and have h…

This study looks at whether the weight-loss medication Contrave (naltrexone/bupropion) increases the risk of serious heart problems like heart attacks, strokes, or heart-related death. About 8,600 obese or overweight adults with heart risk factors will be randomly assigned to tak…

This study tests whether the weight-loss drug phentermine, currently approved for only 12 weeks, can be safely used for up to 2 years. About 870 adults with obesity will take phentermine and receive online lifestyle coaching. Researchers will track weight loss, blood pressure, an…

This study looks at whether eating only during certain hours of the day (time-restricted eating) helps adults with obesity lose weight and improve health. About 162 participants will be assigned to either early or late eating windows or standard daily calorie restriction for one …

This study compares two approaches for treating type 2 diabetes in teenagers: weight-loss surgery (vertical sleeve gastrectomy) versus intensive medical therapy (including metformin and other drugs). The goal is to see which method provides better blood sugar control and reduces …

This study tests whether a gamified mobile health program, including a neurotraining video game, can help overweight men lose weight. 228 men will use either a standard mHealth app or a fully gamified version with team competition and digital rewards. The goal is to see if gamifi…

This study tests whether limiting food intake to an 8-hour window each day (between 10am and 6pm) for 2 months helps children and teens with obesity lose weight. Researchers will also check if any benefits last and explore how the gut microbiome and body clock might play a role. …

This phase 2 trial tests different doses of tirzepatide in 414 adults with type 2 diabetes and obesity who already take metformin. The goal is to see if the drug helps with weight loss and blood sugar control. Participants receive either tirzepatide or a placebo for about 89 week…

This study tests a postbiotic supplement called ABB C3 in 70 children and teens with obesity. Half take the supplement and half take a placebo for 3 months, with an optional 3-month extension for all. Researchers will measure changes in body fat and blood sugar levels to see if t…

This study tests a new drug called taldefgrobep alfa (BHV-2000) to help adults with overweight or obesity lose weight. About 150 participants will receive either the drug or a placebo as a weekly or monthly injection for 24 weeks. The main goal is to see how much body weight chan…

This trial compares two versions of a procedure called TORe, which is used to help people who have regained weight after gastric bypass surgery. One version is the classic TORe, and the other is a newer version called ESD-TORe. The study will look at which one leads to more weigh…

This study will offer shared medical appointments (group visits) for obesity treatment to over 140,000 patients across 56 Cleveland Clinic primary care practices. About 3,600 adults aged 20-75 with a BMI of 30 or higher will take part. The goal is to see if offering these group v…

This study tests whether a Mediterranean diet adapted to use local Indonesian foods can help obese women lose weight and improve health markers like inflammation and gut bacteria. Fifty-four women will follow either this diet or a standard low-calorie diet for 4 weeks. Researcher…

This study looks at whether a very low-calorie diet (800-960 calories per day) can reduce fat and scarring in the liver for people with obesity and non-alcoholic fatty liver disease (NAFLD). Twenty participants will follow either the low-calorie diet or a standard lower-calorie d…

This study tests whether personalized nutrition coaching, delivered online, can help overweight or obese nurses at an Indonesian hospital lose weight, eat better, and become more active. Over 8 weeks, 44 nurses will receive individual guidance to make lasting lifestyle changes. T…

This study tests whether a probiotic supplement containing Bifidobacterium longum can help overweight or obese children aged 3 to 14 improve their body mass index (BMI). Sixty children will receive either the probiotic or a placebo for 8 weeks, along with lifestyle advice. Resear…

This Phase 2 study tests an experimental drug called AZD6234, given as a weekly injection, for weight loss in adults with overweight or obesity and type 2 diabetes. Participants are already on a stable dose of a GLP-1 medication. The study will compare AZD6234 to a placebo over 2…

This study tests a procedure called Revita DMR, which uses a thin tube to treat the lining of the upper gut, to help people with obesity keep weight off after they stop taking the weight-loss drug tirzepatide. About 315 participants who lost at least 15% of their body weight on t…

This study tests an investigational drug called retatrutide in 643 adults with obesity. The goal is to see if it helps maintain weight loss over about 2.5 years. Participants first take the drug for 80 weeks, then are randomly assigned to continue the drug or switch to a placebo …

This study tests whether taking Urolithin A daily for 6 months helps adults with obesity lose weight while keeping muscle mass and improving metabolism. About 100 participants aged 30-60 with a BMI over 30 will follow a structured diet and sleep program, with half receiving the s…

This study compares two weight-loss surgeries for people with severe obesity (BMI over 45). One is the standard duodenal switch, and the other is a simpler version called SADI. Researchers track weight loss, health improvements like diabetes and high blood pressure, and complicat…

This phase 3 trial tests tirzepatide, a once-weekly injection, in 465 adults with type 1 diabetes who are also overweight or obese. Participants receive either tirzepatide or a placebo for about 20 months. The study measures changes in blood sugar control (HbA1c) and body weight …

This study tests whether adding relationship skills training to a standard weight management program helps Mexican American mothers and adult daughters lose weight and keep it off. The program includes nutrition and physical activity education along with behavior change technique…

This study looks at whether giving tranexamic acid (a drug that helps blood clot) during weight-loss surgery can reduce dangerous bleeding. About 1000 adults having bariatric surgery will be split into two groups: one gets the drug, the other gets standard care. The goal is to se…

This study compares two weight loss surgeries for people with severe obesity: sleeve gastrectomy with transit bipartition (SG+TB) and Roux-en-Y gastric bypass (RYGB). About 320 participants will be followed for two years to see which surgery leads to greater weight loss and fewer…

This study compares an intensive weight loss program—using meal replacements, behavior coaching, and weight-loss medication—against standard care for 480 adults with obesity. The goal is to see if the intensive approach leads to greater weight loss, better quality of life, and is…

This study looks at whether a high-protein diet plus resistance training helps people with obesity keep fat off better than a standard low-calorie diet. Sixty adults will follow either a high-protein diet with supervised strength training or a balanced diet alone for 10 weeks, th…

This study is testing a smartphone app that uses artificial intelligence and cognitive behavior therapy to help people with obesity lose weight and improve their health. About 100 adults aged 18 to 65 with a BMI of 27 or higher will use the app for 12 months. The app tracks food …

This pilot study at Mayo Clinic is testing a special low-calorie, high-protein tube feeding formula called Peptamen Intense VHP in 12 obese patients who rely on tube feeding. The goal is to see if it helps them lose weight while maintaining muscle mass, and also improves blood pr…

This study looks at whether adding the drug insulin detemir to a low-calorie diet helps obese adults with type 2 diabetes lose more weight and improve brain function related to food reward. About 240 people will be split into two groups: one on diet only, the other on diet plus d…

This 16-week study tests whether an avocado-based dietary supplement (Metavo) can help overweight adults manage their weight and blood sugar. Sixty participants will take either the supplement or a placebo daily, and researchers will track changes in body weight, glucose levels, …

This study tests a new injectable drug called nimacimab, given weekly, to see if it helps overweight or obese adults lose weight. Some participants will receive nimacimab alone, others will get it together with semaglutide (a known weight-loss drug), and some will receive a place…

This study tests whether three culturally tailored diet patterns (U.S.-style, Mediterranean, and vegetarian) can improve eating habits and reduce type 2 diabetes risk in 198 African American adults. Participants attend weekly classes for 6 months, then bi-weekly for another 6 mon…

This study tests whether a device that gently stimulates the vagus nerve through the ear can improve how the body handles sugar and affect mood in people with obesity and prediabetes. Seventy participants will use the device for 45 minutes, three times a week for three months. Th…

This phase 3 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can reduce the risk of heart attacks, strokes, heart failure, and death in over 15,000 adults with obesity. Participants either have established heart disease or are at high risk. The …

This study looks at whether intermittent fasting (eating only two small meals one day per week) can help overweight veterans maintain weight loss after a 12-week diet and exercise program. Researchers will compare this approach to a standard heart-healthy maintenance plan in 175 …

This study tests whether adding a weekly injection of exenatide (Bydureon) to family-based behavioral treatment helps children aged 10-12 with obesity lose weight more effectively. The trial involves 63 children and their parents, with weekly sessions over 24 weeks. Researchers w…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This study tests a new medication, maridebart cafraglutide, to see if it helps adults with type 2 diabetes who are overweight or obese lose more weight than a placebo. About 1,100 participants will receive either the drug or a placebo for 72 weeks. The main goal is to measure the…

This was a planned phase 3 study to test a new combination of two drugs, sibutramine and topiramate, for weight loss in overweight and obese adults. The study aimed to see if the combination worked better than either drug alone or a placebo. However, the trial was withdrawn befor…

This study tests a new drug called IBI362 in 98 Chinese adults with moderate to severe obesity (BMI ≥ 32.5). Participants receive weekly injections of IBI362, tirzepatide, or a placebo for several weeks. The main goals are to check safety, side effects, and how the drug behaves i…

This study tests a new drug called maridebart cafraglutide to help adults in Japan with obesity lose weight. About 279 participants will receive either the drug or a placebo for 72 weeks. The main goals are to see how much weight they lose and if at least 5% of body weight is los…

This study tests whether combining anti-obesity medications with a structured lifestyle program can help people with obesity lose weight and keep muscle. 150 participants will first take tirzepatide or semaglutide for 9 months, then switch to another oral medication for 12 months…

This study will follow 5,000 adults who have had endoscopic procedures for weight loss, such as stomach stapling through a scope or gastric balloons. Researchers will track weight, blood pressure, diabetes, and cholesterol for up to 10 years to see how well these procedures work …

This study tests an experimental drug called VK2735, given as a weekly injection, to help people with obesity or overweight lose weight. About 4500 adults without diabetes will receive either the drug or a placebo for 78 weeks. The main goal is to see how much weight they lose an…

This study tests whether a weight loss program delivered through a patient portal (like a health app) helps overweight adults lose more weight than standard health education. About 250 participants will be randomly assigned to either the active program or a comparison group. The …

This study was designed to treat toddler obesity by improving the food environment at home. Parents would take part in a free online nutrition program and could also take weight-loss medication. The goal was to help both parent and child lose weight. However, the study was withdr…

This study looks at whether taking a daily multivitamin can prevent vitamin and mineral deficiencies in people using GLP-1 drugs (like tirzepatide) for weight loss. About 246 adults with obesity who have been on a stable GLP-1 dose for at least 3 months will be randomly assigned …

This pilot study is testing the drug tirzepatide (Zepbound) in 40 older adults with obesity to see how it affects body composition, bone density, and physical function over nine months. Participants take weekly injections, track their diet and activity, and attend regular check-i…

This study looks at whether a very-low-calorie ketogenic diet (VLCKD) helps people with severe obesity and metabolic syndrome lose more weight and improve heart health over three years compared to a standard Mediterranean diet. About 100 adults aged 55-75 will be randomly assigne…

This study tests whether a year-long program that teaches cooking, nutrition, mindfulness, and exercise can help adults with obesity improve their health. 320 participants will attend weekly classes for 16 weeks, then monthly boosters. Researchers will measure changes in eating h…

This trial tests whether actively screening adults with obesity for early signs of heart failure can improve their health outcomes. Adults aged 45 and older with a BMI of 30 or higher, who have no known heart disease, will be randomly assigned to receive either standard care or a…

This study follows 300 children aged 9 to 14 with obesity to see if ultrasound and MRI can detect early signs of liver disease. Researchers will compare imaging markers like liver fat and stiffness with standard tests. The goal is to improve diagnosis and monitoring without invas…

This study looks at whether two blood markers, PLIN2 and RAB14, can accurately diagnose NASH (a serious liver disease) and advanced scarring, without needing a liver biopsy. Researchers will test these markers in 828 adults with NASH, type 2 diabetes, or obesity. If successful, t…

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This study tests community-based programs in six countries to help children ages 6-13 eat healthier and be more active. The goal is to prevent obesity and improve quality of life in disadvantaged urban communities. Researchers will track changes in body mass index and health-rela…

Researchers are testing a school program that teaches children about healthy eating, physical activity, and sleep to improve heart health. The trial involves 840 children in 50 elementary schools in Spain. Schools are assigned to either start the program in 2nd grade with a boost…

This study tests a program that uses kindergartens, families, and hospitals to prevent obesity in children aged 4-6. About 980 children in China will take part. The program includes teacher training, health lessons, parent education, and check-ups. Researchers will measure change…

Researchers at Cornell University are testing whether a produce prescription program helps adults who have diet-related conditions and trouble affording food. Participants receive weekly boxes of fresh local produce for 8 to 24 weeks and attend eight nutrition education classes. …

This study tested a program that improved the food served in school breakfasts and lunches in six rural Arkansas school districts. Over 11,500 students were involved, with some schools using the new program and others sticking with their usual meals. The goal was to see if health…

This trial tests a combined nutrition education package for mothers of children under five in Debre Berhan, Ethiopia. The program promotes dietary diversity, limits high-energy foods, and guides food choices to address undernutrition and overnutrition at the same time. Researcher…

This study tests a culturally tailored healthy eating program for Hispanic mothers and their children aged 7–12 in rural Arkansas. The program includes home lessons and cooking workshops to improve diet and cooking habits. Researchers will compare 16 mother-child pairs who get th…

This study tests two behavioral programs—Appetite Awareness Training and the Diabetes Prevention Program—to see if they can reduce binge eating and prevent weight gain in Black women aged 18-25 who are at risk for type 2 diabetes. Participants will attend 16 core sessions over si…

This study tests a program called BasketballRx, which combines basketball activities with lessons on healthy eating, exercise, sleep, and stress management. The program is designed for teens aged 10 to 15 who are overweight or have obesity, and who identify as Black or Latino. Ov…

This study tests whether a high-fiber diet centered on legumes like dry beans can help overweight or obese adults who have had colon polyps lose weight and reduce their risk of colon cancer. Participants follow a diet with pre-portioned meals for up to a year, with nutritionist s…

This study tests whether community health workers can help adults with chronic illnesses get up-to-date on COVID-19 and flu vaccines. Participants receive up to three counseling sessions in English or Spanish to address their vaccine concerns. The goal is to reduce health dispari…

This study tests whether a smartphone app that sets daily step goals can help middle-aged adults (30-70 years old) who are overweight walk more. Participants use a Fitbit and receive adaptive goals to increase light physical activity. The goal is to see if this simple approach ca…

This study looks at how to best bring MINISTOP 3.0, a mobile app for parents, into Swedish primary child healthcare. The app aims to help parents of 2.5- to 3-year-olds encourage healthy eating, physical activity, and less screen time. Researchers will compare two ways of rolling…

This pilot study will test whether providing Mediterranean diet groceries plus virtual nutrition classes helps overweight adults at risk for type 2 diabetes improve their diet and lose weight. Forty participants in the US South will be randomly assigned to receive either weekly g…

This study compares time-restricted eating (eating only between 12pm-8pm) to daily calorie restriction for weight loss and colorectal cancer risk reduction in 193 obese adults aged 45-70. Participants follow their assigned diet for 6 months, then a maintenance phase for another 6…

This study tests whether a weight loss program for overweight or obese women (and their partners) before pregnancy can reduce the risk of their child becoming overweight. 240 couples are randomly assigned to either a very low-calorie diet and counseling or no intervention. The ma…

This study tests an 8-week online program called EatGrow, where parents and their preschool-aged children (ages 3-5) learn about nutrition, cook together, and taste new foods. The goal is to see if it helps kids eat more fruits and vegetables and become more willing to try new fo…

This study is testing a digital health platform called STELA that creates personalized lifestyle plans to reduce risk factors for heart disease, like obesity, high cholesterol, and insulin resistance. About 100 adults without existing heart disease will use the platform for a yea…

This study tests a 2-year personalized program for overweight children aged 6-7 that includes diet advice, physical activity, psychology, and relaxation techniques. The goal is to reduce their body mass index (BMI) and prevent obesity. Researchers will compare results to a histor…

This study tests a school-based lifestyle program to prevent obesity in children aged 4-7 in Karachi, Pakistan. The program encourages healthy eating, drinking water, physical activity, and less screen time. Researchers will measure changes in teachers' and parents' knowledge, at…

This study tests a mobile health program called Fit for Duty-mobile to help 350 active-duty Air Force members aged 18-39 prevent weight gain over 2 years. Participants use a smartphone app, get coaching calls, and wear a Fitbit. The goal is to see if this approach can stop unheal…

This study tests whether giving breastfeeding mothers a natural nutrient called betaine can help prevent rapid weight gain in babies, which is linked to later obesity. About 47 mothers with overweight or obesity will take betaine or a placebo for 3 months while exclusively breast…

This study tests whether adding a natural nutrient called betaine to infant formula can safely prevent excessive weight gain in babies at risk for childhood obesity. Researchers will compare growth and gut bacteria in 50 formula-fed infants whose mothers had a higher pre-pregnanc…

This study tests a program where Black mothers and their 9th- or 10th-grade daughters work together to increase physical activity and improve diet, aiming to prevent obesity. About 120 pairs will join, with daughters at higher risk due to weight. The program uses activity tracker…

This study looks at how genetics, eating habits, and lifestyle affect obesity risk in adults aged 18 to 70 in Georgia. One hundred participants will be split into two groups: one follows a reduced-portion diet and exercise plan for 8 weeks, while the other serves as a control. Re…

This study looks at whether a community-based program focused on healthy eating and exercise during and after pregnancy can lower the chances of obesity and type 2 diabetes in mothers and their children. About 1,000 pregnant women in urban areas will take part. The goal is to see…

This study looks at whether adding CPAP (a machine that helps you breathe at night) to a healthy lifestyle program can lower the risk of diabetes in people with prediabetes and sleep apnea. About 174 overweight or obese adults with both conditions will be followed for 6 months. T…

This study tests a personalized coaching program for low-income Hispanic families with young children (ages 4-6) to prevent obesity. The program helps families overcome daily barriers to healthy eating and physical activity. 301 parent-child pairs will be followed for several yea…

This study tests a program to help new bus operators avoid gaining weight and succeed at work. About 284 new hires from several transit agencies will take part. Some will get the special program, while others follow usual routines. The goal is to see if the program helps them sta…

Researchers are comparing two ways to perform total knee replacement in patients with obesity and knee arthritis. One method uses custom-made guides based on each patient's knee scans, while the other uses standard surgical tools. The trial measures how well the knee aligns, how …

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study looks at whether time-restricted eating (a form of intermittent fasting) is a practical way for veterans with spinal cord injury and obesity to lose weight. Fifteen veterans with paraplegia will try eating all their daily calories within a set window of time for 6 week…

This study tested a 24-week weight loss program delivered via video calls for 22 breast cancer survivors who were overweight or obese. The goal was to see if the program was practical and well-liked, and whether it improved quality of life, physical activity, and mood. Participan…

This study looks at two ways to manage pain during weight-loss surgery (sleeve gastrectomy) in 70 adults. One group gets standard opioid painkillers, the other gets a mix of non-opioid drugs. The goal is to see if the opioid-free approach can reduce opioid use and still control p…

This study tests a once-weekly injection called retatrutide to see if it can reduce chronic low back pain and help with weight loss in people who have obesity or overweight. About 586 participants will receive either the drug or a placebo for up to 80 weeks. The goal is to find a…

This study tests whether a 4-week program addressing weight stigma and self-blame can help teens (ages 13-17) better manage their weight. Participants are randomly assigned to either the stigma-focused program or a general health education session, followed by a 16-week weight ma…

This study is testing a mobile app designed to help teenagers who struggle with binge eating and are overweight or at risk for obesity. The app uses strategies from cognitive-behavioral therapy to improve self-regulation and eating habits. Fifty teens will use the app for 16 week…

This pilot study is testing whether a mulberry leaf extract supplement (Reducose) can help control blood sugar spikes after meals in obese children and adolescents. Eighty participants will take either the supplement or a placebo twice daily for 12 weeks. Researchers will measure…

This study compares the effects of soy soft pretzels and wheat pretzels on inflammation in 30 men with obesity. Researchers want to see if the natural chemicals in soy can reduce chronic inflammation, which is linked to health problems like cancer. Participants will eat either so…

This study tests whether a 16-week mindfulness-based nutrition group program is feasible and acceptable for adults with obesity who are already taking GLP-1 medications. Forty participants will either join the group program plus usual care or receive usual care alone. The program…

This study tests an 8-week mindfulness program (MB-EAT) for people who had bariatric surgery at least six months ago and struggle with eating guidelines. About 85 participants will be split into two groups: one gets the mindfulness training, the other does not. Researchers will t…

This study tests whether drinking hydrogen-rich water can make a 4-week weight loss retreat more effective for overweight and obese teens. Sixty adolescents will be randomly assigned to get either hydrogen water or plain water, while all follow the same retreat program. Researche…

This study looks at how losing weight affects sexual function and sperm quality in men with severe obesity. About 59 men will either have weight-loss surgery or follow a standard diet plan. Researchers will measure changes in sexual health, hormone levels, and sperm quality to se…

This study looks at whether adding online yoga classes to an internet-based weight loss program can help people lose more weight and keep it off. About 210 adults with obesity will take part. Everyone gets a 12-month online weight loss program, and after 3 months, some also get y…

This study looks at whether a low dose of esketamine, given during and after weight-loss surgery, can help reduce depression in patients who were already depressed before surgery. Forty adults with a BMI over 35 and a Hamilton Depression score of 7 or higher are taking part. The …

This study looks at whether exercising once a week or three times a week is better at reducing liver fat in adults who are centrally obese and have non-alcoholic fatty liver disease (NAFLD). Three hundred Chinese adults aged 18-69 will be assigned to either a once-weekly or thric…

This study looks at whether two types of exercise training can improve body composition, heart and lung function, and quality of life in people who have had bariatric surgery. Researchers will compare high-intensity interval training (HIIT) and moderate-intensity continuous train…

This study tests whether adding virtual reality (VR) training to standard balance exercises can improve balance, stability, mobility, and quality of life in people with obesity. Sixty participants aged 20-40 with a BMI between 30 and 40 will be randomly assigned to either balance…

This study tests whether a mix of ketamine and dexmedetomidine (ketodex) can reduce the need for strong painkillers after laparoscopic sleeve gastrectomy in obese patients. Eight adults with a BMI over 35 are randomly assigned to receive either ketodex or standard opioid-based an…

This study tests whether adding group weight-loss classes to standard cardiac rehabilitation helps people with atrial fibrillation and obesity lose at least 10% of their body weight. About 120 adults will take part, with half getting the extra classes. The goal is to see if this …

This pilot study aimed to test a parent-only training program for children aged 8-12 with both ADHD and overweight or obesity. Parents would learn weight management skills and strategies to help their child's focus and planning. However, the study was withdrawn before any partici…

This study looks at whether 8 weeks of resistance training with blood flow restriction can improve muscle strength, body measurements, and health markers in adults with obesity. Thirty participants aged 18 to 40 with a BMI between 30 and 40 will do leg and arm exercises using lig…

This study tests whether high-flow oxygen therapy can prevent low oxygen levels (hypoxemia) in patients at higher risk during sedated digestive endoscopy. The trial includes 326 adults with obesity, sleep apnea, or stable lung or heart conditions. Researchers will compare high-fl…

This study tests a smartphone app called eTRIP, which uses artificial intelligence to help people with overweight or obesity make healthier food choices and stick to their weight loss goals. Some participants also wear a continuous glucose monitor for 10 days to see how their blo…

This study tests whether virtual reality sessions with a psychologist can improve body image dissatisfaction in people who had bariatric surgery 18 to 30 months ago. Eleven participants will either receive 10 weekly VR sessions or standard follow-up care. The main goal is to see …

This study aimed to see if making physical activity into a game could help older hospital patients move more. Participants would have received daily text messages, set step goals, earned points, and worn a Fitbit to track their steps. The study was withdrawn before any patients w…

This study tests a 6-month program for adults with a BMI of 30 or higher that aims to improve mental, social, and physical health without targeting weight loss. It uses intuitive eating and therapy techniques to help people eat based on internal cues and manage body image concern…

This study compares two types of weight-loss surgery—sleeve gastrectomy alone versus sleeve gastrectomy with transit bipartition—to see which leads to fewer cases of dumping syndrome (nausea, diarrhea, dizziness after eating) and better quality of life. Researchers will follow 20…

This study looks at whether taking probiotics after sleeve gastrectomy (a type of weight-loss surgery) can reduce constipation and other stomach issues. About 200 adults with severe obesity will take either a probiotic blend or a placebo for three months after surgery. Researcher…

This study compares two approaches to help rural adults with obesity lose weight. One method involves quarterly one-on-one visits with a primary care doctor. The other adds a group lifestyle program over Zoom plus quarterly team meetings with the doctor and a lifestyle coach. Res…

This study looks at whether a low-fat diet can increase reproductive hormones in women with obesity. Thirty women with regular cycles and no other hormone issues will follow a carefully controlled diet. The goal is to see if diet alone can improve hormone levels linked to fertili…

This study tests an internet-based treatment program for adults with obesity. The program includes 12 modules over six months, focusing on lifestyle changes and weight control. Researchers want to see if it improves quality of life and leads to weight loss. About 100 people are t…

This study looks at how different types of ultra-processed foods—like those high in fat, sugar, or both—affect feelings of reward and overeating. Fifty adults with obesity will eat various snack foods in the lab and report their cravings and mood. The goal is to understand what m…

Researchers are studying HDM1005, an experimental injection for overweight and obesity, to see if the body absorbs it differently depending on where it is injected. The trial compares injections given in the upper arm and thigh against injections in the abdomen. About 135 healthy…

This early-stage study looks at how taking a new tablet called CX11 with or without food changes the amount of drug in the blood. It involves 32 healthy adults and does not aim to treat any disease. The results will help researchers decide how to give the drug in future studies f…

This study looks at how compounds from mango (gallotannins) and a probiotic called Lactiplantibacillus pentosus affect gut bacteria and inflammation in people with obesity. Researchers will analyze stool samples from 20 participants (lean and obese) after giving them mango juice,…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…

This observational study follows adults with morbid obesity who undergo bariatric surgery to see if substantial weight loss changes the alignment of their hips, knees, and ankles. Researchers measure leg alignment using standing X-rays before surgery and at 3, 6, and 12 months af…

This observational study follows adults with morbid obesity who undergo bariatric surgery to see how substantial weight loss affects the alignment of the spine and pelvis. Researchers measure spinal and pelvic positions on X-rays before surgery and again at 3, 6, and 12 months af…

This study looks at whether overweight girls start puberty earlier than girls of normal weight. Researchers will use breast ultrasound and other tests to tell the difference between breast tissue and fatty tissue. The study involves 150 healthy girls ages 8-14 who have some breas…

This study follows 500 obese adults to see how different factors like diet, exercise, stress, and sleep affect weight loss. Researchers collect blood tests, measurements, and questionnaires at the start and during follow-up. The goal is to find patterns that could lead to more pe…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study investigates why brown fat, which burns calories to generate heat, stops working when it's warm. Researchers will use cold vests on 8 healthy and obese adults to see how genes and proteins change. The goal is to find new targets for treating obesity and related metabol…

Researchers are testing a transition program for 17-year-olds with type 1 diabetes, asthma, or obesity who are preparing to move from pediatric to adult healthcare. The program includes a consultation with the teen and family, a solo visit where the teen completes a readiness che…

Researchers at the Royal Free Hospital are testing whether electrical impedance tomography (EIT), a radiation-free imaging method that uses a chest belt and low-level electrical currents, can help clinicians adjust breathing machines for people with chronic respiratory failure. T…

This early-stage study looks at how the experimental drug BI 456906 attaches to receptors in the liver and pancreas that control appetite and weight. About 30 adults with obesity will receive either BI 456906 or the approved weight-loss drug semaglutide for 17 weeks. Researchers …

This study looks at how a baby's emotions, attachment to mom, and feeding habits work together to affect weight gain in the first year of life. Researchers will follow 250 mother-infant pairs to understand what leads to healthy growth or future obesity. The goal is to find ways t…

Researchers are studying whether a mother's weight and blood sugar during pregnancy affect the makeup of her breast milk, and whether those differences influence how her baby grows. The study will follow pregnant women with a range of body sizes, including those with gestational …

Researchers at a South African hospital are asking whether two questionnaires can reliably capture how patients feel after metabolic surgery for obesity. Adults scheduled for the procedure will rate their comfort, pain, nausea, and return to normal activities before surgery and a…

This study follows up on children who were first tested between ages 8-12, some with obesity and some without, to see how their lungs and exercise tolerance have changed after about 6 years. Researchers will measure lung volumes, oxygen use during exercise, and breathlessness. Th…

This study is testing a 24-week program that combines nutrition counseling, exercise, sleep tips, and stress management for cancer survivors who are overweight. Researchers want to see if the program is practical and helpful for improving sleep quality, reducing stress, and boost…

This study looks at how the body handles different types of meals after losing about 16-18% of body weight through either a low-calorie diet or gastric bypass surgery. Researchers will measure insulin, blood sugar, fats, and other markers in 30 adults with obesity but without dia…

This study follows 250 obese adults who are having a weight-loss procedure—either surgery or an endoscopic stomach reduction. The goal is to see how often acid reflux (GERD) develops afterward, including silent reflux with no symptoms. By tracking symptoms and using tests, resear…

This study looks at how not having reliable access to enough food might make it harder to lose weight. Researchers are giving 12 women who face food insecurity and have obesity and prediabetes a steady supply of healthy, low-calorie meals for a period. They will measure changes i…

This study looks at ways to help adults in rural Pennsylvania become more physically active. It includes 880 people who are overweight, have type 2 diabetes, or are not very active. Researchers will track activity levels using questionnaires and wearable devices to see what works…

This study looks at whether reducing exposure to everyday chemicals called endocrine disruptors (found in plastics, cosmetics, and food) can help people with overweight or obesity lose weight. About 226 participants will either follow a program to lower chemical exposure or use a…

This study tests a smartphone app designed to help adults taking GLP-1 medications for obesity or type 2 diabetes eat better. About 50 participants will use the app for 6 weeks to track their diet and learn about nutrition. The goal is to see if the app is helpful and easy to use…

This study follows 50 adults in a community weight loss program to see how daily stress levels relate to weight loss, physical activity, and sleep. Participants will answer quick surveys on their phones and wear a wrist device to track activity and sleep. The goal is to understan…

This study looks at whether improving sleep can help overweight or obese African Americans who don't get enough exercise become more active. About 28 people will try a sleep program either before or after a physical activity program. The goal is to see if this approach is practic…

This study follows mother-infant pairs from birth to 24 months to see how early nutrition, environmental exposures, and family factors relate to growth, development, and allergies in preterm and term infants. Researchers will use questionnaires and biological samples to examine h…

This study looks at how estrogen levels influence body composition and muscle function in midlife women (ages 35-60) who are starting a GLP-1RA medication for weight loss. Researchers will measure changes in weight, muscle mass, bone density, and strength over time. The goal is t…

This study looks at how eating mostly ultra-processed foods (like packaged snacks) compared to less-processed foods (like whole fruits and vegetables) affects blood pressure and other heart health markers. About 79 overweight adults will follow special diets to see the difference…

This study looks at whether routine blood tests taken before weight-loss (bariatric) surgery can help predict who might face complications within 30 days after the operation. Researchers will review medical records of 600 adults who had bariatric surgery, checking levels of certa…

This study looks at whether exercising in the morning or evening makes a difference in weight loss for people who are overweight. Researchers will track weight, body fat, sleep, and eating habits in 128 adults over 13 months. The goal is to find out if timing your workouts can he…

This study adapts a 'Health at Every Size' program for pregnant people with a BMI over 30. Ten first-time mothers will attend group sessions on nutrition, movement, and self-advocacy. The goal is to see if the program is acceptable and helpful in reducing weight stigma and improv…

This trial tests whether wearable devices can measure how the body responds to everyday challenges like changes in salt intake, meals, fasting, and exercise in adults with endocrine or metabolic disorders. Participants wear home monitoring devices and follow different diet and ac…

This study follows 50 adults who are about to start GLP-1 therapy for obesity or type 2 diabetes. Researchers will track how their eating habits change over 12 weeks using diet quality scores and body weight. The goal is to understand what dietary support people need while on the…

This study aims to measure heart and metabolic risk markers—such as insulin resistance and fat distribution—in young adults aged 18 to 30 with type 1 diabetes and a body mass index under 25. Researchers will track changes over one year using glucose clamps and meal tests. The goa…

This early-stage study looks at how a new weight-loss drug, maridebart cafraglutide, changes the way the body processes oral contraceptives. It involves 45 postmenopausal women aged 45 to 65 who are overweight or obese. The goal is to see if the drug affects birth control hormone…

This observational study uses magnetic resonance imaging (MRI) to track how fat and muscle distribution changes in adults with obesity who undergo bariatric surgery. Participants receive MRI scans before surgery and at 1, 6, and 12 months after to measure visceral fat, subcutaneo…

This study tests whether a biomarker found in saliva can predict how much weight people with obesity will lose when taking semaglutide. Researchers will compare weight changes in biomarker-positive and biomarker-negative participants over 24 weeks. The goal is to personalize obes…

This study looks at how newer weight loss drugs (like semaglutide) compare to gastric bypass surgery in people with severe obesity. Researchers will track changes in muscle, fat, and side effects over a year using body scans and surveys. The goal is to help doctors and patients c…

This study investigates how severe calorie restriction—achieved through weight-loss surgery—changes the types of fat stored in muscle and how muscles respond to insulin. Researchers will compare normal-weight participants with those who are obese and scheduled for gastric bypass.…

This early-stage study tests an experimental drug called PF-08653944 in 20 overweight or obese adults. Researchers want to see how it affects the speed at which the stomach empties food, using a common painkiller as a marker. The main goals are to understand the drug's effects an…

This study investigates why some people with obesity develop heart and metabolic problems while others do not, and which diet—Mediterranean, low-carb, or low-fat—best supports metabolic health. Researchers will follow 300 participants, including lean and obese individuals, over s…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This pilot study will compare two diets—one high in ultra-processed foods and one typical American diet—in 6 adults with overweight or obesity. Participants will try each diet for two weeks in random order. The goal is not to prove which diet is better, but to see if a larger stu…

This study was designed to look at how tiny energy-producing parts of cells (mitochondria) in the liver might be linked to fatty liver disease in people with obesity who were scheduled for weight-loss surgery. Researchers planned to take small liver samples during surgery to stud…

This study looks at whether taking short walks throughout the day is better for kids at risk for type 2 diabetes than one longer exercise session. Researchers will measure blood sugar, insulin, and thinking skills in 188 children aged 8-11 with overweight or obesity. The goal is …

This pilot study looks at whether regularly measuring body fat in very preterm infants (born at 28-32 weeks) can help reduce excess fat gain by 3 months of age. Researchers will use a special machine to measure body composition shortly after birth, at 32 weeks, and again at 36 we…

This study was designed to create a registry of medical information from children aged 1 to 18 with obesity. The goal was to collect historical and clinical data from medical charts to help researchers better understand pediatric obesity. However, the study was withdrawn before e…

This observational study will follow 125,000 adults with employer-based insurance to see how GLP-1 and GLP-1/GIP obesity medications (like Wegovy and Zepbound) affect weight, healthcare use, and medical costs. Researchers will compare people who take these drugs to those who don'…

This study looks at how gastric bypass surgery changes the way the small intestine processes sugar and other fuels, which may explain why the surgery improves obesity and type 2 diabetes. Researchers will collect intestinal tissue and blood samples from 32 people before and up to…

This study looks at how head and neck position (sniffing vs. ramped) and the type of blade used on a video laryngoscope affect how quickly a breathing tube can be placed in 140 severely obese patients (BMI 40 or higher) undergoing elective surgery. The goal is to find the best co…

This study follows 300 families with children aged 2 to 6 years over three years to understand how ongoing stress might lead to weight gain. Researchers will measure stress hormones and behaviors to see what role they play. The goal is to learn, not to test a treatment, so no new…

This observational study looks at whether a computer program can analyze voice recordings to predict weight loss success in Latino adults with obesity. Researchers will record participants answering one question about their weight loss journey and use AI to guess their personalit…

This study examines whether low-calorie (low energy density) and high-calorie (high energy density) foods act as substitutes in a meal. Researchers will serve 62 healthy-weight adults different combinations of foods across four sessions and measure how much they eat. The goal is …

This study was designed to see how well the stomach-acid drug dexlansoprazole is absorbed before and after gastric bypass surgery, and how often ulcers occur afterward. It planned to enroll smokers with obesity who were scheduled for surgery. However, the study was withdrawn befo…

This study tests whether Eatable Alphabet cards—a fun, child-friendly nutrition tool—can help kids ages 2 to 10 with overweight or obesity eat more fruits and vegetables. About 160 children in a weight management program will use the cards, and parents will report changes in thei…

This study looks at 54 obese women getting knee replacements to see if a stemmed or non-stemmed tibial implant works better. The goal is to find out which type reduces the risk of the implant collapsing or loosening over time. Researchers will track these outcomes to guide future…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study looks at whether digital health tools like text messages, videos, or AI conversations can improve the physical and mental health of middle school students. About 800 students aged 11 to 13, with normal weight, overweight, or obesity, will be split into four groups to c…

This study explores whether genetic differences explain why some people benefit more from chili pepper compounds (capsaicinoids) for weight control. Researchers will give supplements to 100 adults with overweight or obesity and measure changes in body fat, appetite, and metabolis…

This study tests whether a remotely delivered resistance training program is practical and helpful for Black women aged 30-64 who are overweight, have prediabetes or diabetes, or have high blood pressure. About 37 women will participate from home using their own devices. The goal…

This study tests whether a swallowable camera capsule, controlled by magnets from outside the body, can safely and effectively examine the stomach and esophagus in 30 people preparing for weight loss surgery. Participants swallow the capsule after fasting, and a surgeon guides it…

This study looks at how immune cells in different types of body fat (belly fat vs. fat under the skin) are linked to insulin resistance, a condition where the body doesn't use insulin well. Researchers will analyze fat samples from 50 people having weight-loss surgery to see if c…

This study directly measures how GLP-1 medications (like Ozempic) change the way people eat. Researchers use a special device to track every sip of sugary and fatty drinks in 140 adults with obesity. The goal is to understand exactly how these drugs reduce calorie intake, not jus…

This study looks at whether taking weekly cold water baths (18°C) for at least 12 weeks can boost brown fat activity in people with obesity. Brown fat is a type of body fat that burns energy to generate heat. Researchers will use special scans to measure blood flow and fuel use i…

This study follows 225 pregnant women—some who had gastric bypass or sleeve gastrectomy, and some without surgery—to see how blood sugar changes affect fetal growth. Participants wear a continuous glucose monitor and activity tracker for 10 days each trimester. The goal is to lea…

This study was designed to test whether a fasting-mimicking diet (FMD) can activate beige/brown adipose tissue—a type of fat that burns calories—in people with overweight. Researchers planned to measure changes using PET scans, thermal imaging, and blood tests. However, the study…

This study looks at how brown adipose tissue (brown fat) changes when young adults with obesity follow a calorie-restricted diet to lose 8-10% of their body weight. Researchers will use PET-CT scans and molecular tests to measure brown fat activity and compare it to a group maint…

This study was designed to see if a new type of airway device can prevent dangerous drops in oxygen levels during anesthesia in patients who are at high risk, such as those with obesity or sleep apnea. Researchers planned to compare the new device with standard ones in adults und…

This study aims to collect information from weight management clinics across the UK to understand who uses these services, what treatments they receive, and how well they do. Researchers will enroll up to 41,000 people who are already attending these clinics. The goal is to impro…

This study looks at how amino acids trigger the liver to release hormones in healthy people and those with non-alcoholic fatty liver disease. Researchers will give amino acid infusions with or without a drug that blocks natural hormone production. By comparing the results, they h…

This study looks at how fat tissue takes up sugar in people with obesity, comparing those with normal blood sugar to those with insulin resistance. Researchers will use labeled sugar infusions and PET scans to measure sugar uptake in fat and muscle. The goal is to understand why …

This study tests whether infusing a natural hormone called LEAP2 can reduce how the brain reacts to pictures of food in people with obesity. Twenty-eight men with a BMI between 30 and 50 will receive either LEAP2 or a placebo on two separate days and undergo brain scans. The goal…

This study looks at how changing the length of the small intestine re-routed during gastric bypass surgery affects metabolism and inflammation. Researchers will compare two surgical techniques in 50 people with severe obesity and also include 15 healthy lean individuals as a comp…

This study uses PET scans to look at the brain's reward system in 30 people who had bariatric surgery 2-3 years ago. Researchers want to see if differences in dopamine receptors explain why some patients lose more weight than others. Participants will have brain scans before and …

This study reviews medical records of 300 adults with overweight or obesity who took weight management medications. Researchers want to see how much weight patients lost after 12 months and whether blood sugar and cholesterol improved. No new treatments or visits are required—onl…

This small pilot study looks at how eating foods made with soybean oil or palm oil every day for four weeks changes blood fatty acids and body weight in overweight adults. Sixteen participants will try both oils in a crossover design. The goal is to see if people can stick with t…

This study aimed to see if adding pramlintide to semaglutide (Wegovy) could change appetite and eating habits in obese people with prediabetes. It also tried to find ways to predict who would respond best to obesity medication. The trial was withdrawn before any participants were…

This study was designed to see if adding the amino acid isoleucine to a healthy, low-isoleucine diet would change how the body responds to insulin in people with obesity and prediabetes. It planned to enroll adults with a BMI of 30 or higher who also had metabolic syndrome. The s…

This study looks at how eating meals with high or low 'reward value' (like tasty vs. bland food) affects brown fat activity and gut-brain signals. Researchers will scan 30 lean and overweight adults to measure changes in brown fat, gut hormones, and brain receptors after each mea…

This study looks at how popular weight-loss drugs like semaglutide and tirzepatide affect food cravings and diet quality in people with obesity. Over 24 weeks, participants fill out surveys and food diaries to track changes. The goal is to understand whether these medications imp…

This study tests a new classroom setup where traditional desks are replaced with standing desks, fitballs, and wall boards to get kids moving more. Researchers will track 500 students in Spain to see if this reduces sitting time and improves thinking, fitness, and well-being. The…

This study looks at whether regular exercise while breastfeeding changes the makeup of breastmilk in mothers who are overweight or have obesity. Researchers will measure specific sugars and other compounds in the milk and see if these changes affect the baby's growth and health. …

This study looks at whether measuring body water with a harmless device can help detect obstructive sleep apnea (OSA) in pregnant women with severe obesity. OSA is common but often missed in this group, and can be dangerous for both mother and baby. Researchers will enroll 52 wom…

This study follows 100,000 Chinese families from before pregnancy through the child's teenage years. Researchers collect health data, biospecimens, and environmental information to understand how parents' exposures affect pregnancy outcomes and child development. The goal is to f…

This 12-month study looks at how a lifestyle program—including group sessions and support from a nurse, dietitian, and kinesiologist—may help women aged 35-75 with obesity improve their weight, heart health, and body image. Some participants may also use GLP-1 weight-loss medicat…

This study looks at how iron levels in the brain, gut bacteria, and blood sugar are connected to thinking and memory in people with obesity. Researchers will track 138 adults aged 30-65 using brain scans, glucose monitors, sleep trackers, and cognitive tests. The goal is to under…

This study looks at how a continuous 72-hour dose of glucagon (a hormone) affects energy expenditure in healthy, non-diabetic obese adults. About 30 participants will receive either glucagon or a placebo through an IV. The goal is to understand the body's energy use, not to treat…

This early-phase study tests how well 20 healthy obese adults tolerate increasing doses of glucagon, a hormone that raises blood sugar. Researchers measure nausea levels to find the highest dose people can handle before feeling sick. The goal is simply to understand tolerability,…

This study looks at how exercise changes the signals muscles send to the rest of the body, especially those that help burn fat. Researchers will compare obese, lean, and athletic participants to find proteins or genetic codes released from muscle during exercise. The goal is to b…

This study aims to understand why people on a weight loss program sometimes break their diet rules (called 'lapses'). Researchers will use smartphone surveys and wrist sensors to track behaviors, feelings, and surroundings in 150 adults with obesity. The goal is to identify patte…

This study looks at how genes and fat cells differ in people with apple-shaped (belly fat) versus pear-shaped (hip and thigh fat) bodies. Researchers will use body scans and fat biopsies from 27 healthy adults to compare fat tissue at the molecular level. The goal is to better un…

This study looks at how natural compounds in strawberries and raspberries (polyphenols) affect inflammation and gut bacteria in overweight adults with mild inflammation. About 105 participants will eat berry products or a control diet for 4 weeks. Researchers will measure blood a…

This study looks at why children and teens choose to be physically active. Researchers measured fitness, motor skills, thinking abilities, and motivation in 325 third-graders. The goal is to learn how to encourage kids to stay active for better long-term health.

This study looks at how nutritional counseling and exercise affect telomeres—the protective caps on our chromosomes that shorten as we age—in elderly women. Researchers will compare women with and without obesity, measuring changes in telomere length and other aging markers after…

This study is testing whether a Mediterranean-style low-carb diet that reduces calories can lower insulin and testosterone levels in overweight or obese women with insulin resistance. Eight premenopausal women aged 21-45 will follow the diet to lose about 5% of their body weight.…

This study follows 50 obese patients who are having weight-loss surgery (laparoscopic sleeve gastrectomy). Researchers use MRI scans and blood tests before surgery and at 1, 3, and 6 months after to measure changes in pancreatic fat and insulin function. The goal is to see if los…

This study looks at how diet and exercise affect the epigenome—chemical marks on DNA—in sperm of overweight Hispanic men. Researchers will compare sperm from 20 healthy active men and 80 obese inactive men before and after a 12-week program of diet, exercise, or both. They will a…

The ALOHA study is a community-based research project for adults aged 50 and older in the Washington, D.C., Maryland, and Virginia area. Over five years, participants receive annual health assessments—including physical and cognitive tests—and get a personalized 'Health Passport'…

This study investigates how obesity-related factors like high insulin and fat levels may disrupt fertility in women. Researchers will measure hormone changes and metabolic responses in 84 women. The goal is to understand the underlying causes and inform future treatments to impro…

This study compares an 8-week virtual group program called the Healthy YOU Program to standard weekly email tips for overweight adults. Researchers want to see if the program helps people eat better, move more, and keep those changes for at least 3 months. They will also look at …

This early-phase study at Vanderbilt University Medical Center is looking at how certain nerve signals (called sympathetic vasoconstriction) might interfere with insulin's ability to widen blood vessels and take up sugar. The researchers will give a drug called phentolamine into …

This study looks at 49 adults who had bariatric surgery at least 5 years ago and later regained weight or didn't lose enough. Researchers want to understand how disordered eating, emotional eating, and nutrition affect weight regain. The goal is to help create better follow-up ca…

This study aimed to find the best level of breathing support (PEEP) for severely obese patients on ventilators. Researchers planned to compare two PEEP levels during breathing tests to see which helped patients breathe easier and come off the ventilator sooner. However, the study…

This study looks at why people who lose weight often experience a greater-than-expected slowdown in metabolism, making it harder to keep weight off. Researchers will compare three lifestyle approaches—resistance training, calorie restriction, and time-restricted eating—in 75 over…

This study looks at how amino acids (building blocks of protein) affect the release of glucagon and insulin compared to sugar alone. Researchers will test 30 adults who are healthy, have type 2 diabetes, or are obese. The goal is to better understand these hormone responses, not …

This study looks at whether losing weight through gastric bypass surgery changes bile acids differently than losing weight through a strict low-calorie diet. Researchers will measure bile acid levels in stool samples from 21 people with obesity. The goal is to understand if the s…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…

This study looks at whether an 8-week program of eccentric (lengthening) resistance training can improve muscle strength, nerve function, and health markers like blood sugar and cholesterol in obese, inactive women. 24 women aged 25-45 with a BMI over 23 will be assigned to eithe…

This study follows over 5,000 Black and White men and women from age 18-30 for many years to see how their lifestyles and health habits affect their risk of heart disease later in life. Researchers measure things like blood pressure, weight, and cholesterol to understand why some…

This study looks at why some people with obesity develop conditions like type 2 diabetes while others don't. Researchers are comparing three popular diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 participants to see how they affect insulin sensitivity and over…

This study creates a registry of 240 patients hospitalized with decompensated heart failure with preserved ejection fraction. Researchers will track medical history, body composition, imaging, and blood markers to see how these factors relate to short- and long-term outcomes. The…

This study looks at how empathy—understanding and sharing others' feelings—relates to binge eating and relationship problems in adults with obesity. Researchers will test 155 people in a nutritional program using emotion-recognition tasks and questionnaires. The goal is to better…

This study looks at how exercise training changes the way muscles process fat and sugar, which is linked to insulin resistance and type 2 diabetes. Researchers will study healthy, lean, and overweight participants before and after a 16-week running or yoga program. The goal is to…

This study follows 70 healthy infants from rural Pakistan over their first two years of life. Researchers will regularly test the babies' gut bacteria to see how it changes and whether it relates to their growth and nutrition. The goal is to understand why some children become ma…

This study tests different ways to reach and enroll women and Black/Latino adults in heart disease research. Participants receive educational text messages about heart health and research opportunities. The goal is to see if these methods increase diversity and trust in clinical …

This study follows 317 adults with type 2 diabetes who were first examined between 2019 and 2023. Researchers will repeat advanced liver scans, blood tests, and body composition measurements to see how liver fat and scarring change over time. The goal is to find out who is most a…

This study aimed to see if exercising in the morning versus the evening changes how the body handles sugar in adults with prediabetes. Participants would have completed short bouts of morning exercise, evening exercise, and no exercise, with their blood sugar and insulin levels m…

This study looks at how exercising in the morning versus the evening, and on an empty versus full stomach, changes the way your body burns energy and fat. Researchers will measure these effects in 20 adults with overweight or obesity who are already active. The goal is to better …

This study looks at whether giving Fitbit smartwatches to adults aged 65 and older in a doctor-referred exercise program can help them become more active. Researchers will track how many people join, attend, and complete the program, and how they feel about using the watch. The g…

This study collects information through online surveys from about 2,500 adults in Australia, Germany, UAE, and Spain who have been prescribed injectable semaglutide for weight management. The goal is to understand their characteristics, treatment experiences, and changes in weigh…

This study follows 113 people scheduled for either gastric bypass or sleeve gastrectomy to see how the surgery affects their social experiences and well-being. Participants will fill out daily diaries about their social interactions and mood at 6 weeks and 1 year after surgery. T…

This study aimed to see if providing medically tailored meals, lactation support, and food for children could help Black women with hypertensive disorders of pregnancy control their weight after childbirth. The trial was withdrawn before any participants were enrolled, so no resu…

This study looks at the genes of 1000 people with severe early-onset obesity to find rare genetic causes. It focuses on conditions like Bardet-Biedl syndrome. The goal is to better understand these conditions and improve how they are diagnosed. Participants provide a blood or sal…

This study aimed to understand how body weight influences the way etanercept works in obese adults and children with arthritis. Researchers planned to use blood samples and computer models to find the best dose for heavier patients. However, the study was withdrawn before enrolli…

This study follows 163 obese patients undergoing bariatric surgery to see if non-invasive tools like ultrasound and blood markers can accurately diagnose fatty liver disease (MASLD) and predict diabetes remission. Researchers will compare these tests to liver biopsy results befor…

This study follows over 3,000 Black people with HIV in the UK to understand how genes and lifestyle affect their risk for kidney disease, heart disease, diabetes, and obesity. Researchers collect health data and blood/urine samples to find genetic markers that predict these condi…