Berry compounds may tame gut inflammation, study suggests
NCT ID NCT04100200
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how natural compounds in strawberries and raspberries (polyphenols) affect inflammation and gut bacteria in overweight adults with mild inflammation. About 105 participants will eat berry products or a control diet for 4 weeks. Researchers will measure blood and stool markers to understand the link between diet, gut microbes, and inflammation.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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105 people
The number who actually took part.
- Started
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Oct 2019
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * C-Reactive Protein (hs-CRP) \> 1.0 and ≤ 10 ng/L * BMI ≥ 25 kg/m2 * Aged 20-60 years * Able to provide informed consent and comply with study procedures * Willing to maintain stable body weight and follow his/her habitual diet and physical activity patterns throughout the trial. * Judged by the Investigator to be in general good health on the basis of medical history and screening laboratory tests. * People with no documented disease condition that would interfere with the study endpoints (ie., CVD, diabetes, hypertension, major organ diseases) or taking medication or dietary supplements that may interfere with study endpoints Exclusion Criteria * Current smoker or marijuana user * No history or presence of atherosclerosis/cardiovascular disease, inflammatory disease, diabetes mellitus, or other systemic diseases, psychological or psychiatric disorders that may interfere with study outcomes. * Taking any medications and/or supplements that would interfere with outcomes of the study (i.e., lipid-lowering medications, anti-inflammatory drugs, etc) * Take part in prebiotics, probiotics or drugs active on gastrointestinal motility or a laxative of any class within 1 month * Unstable use of any medication/supplement, this could include marijuana used as -needed for medical reasons * Have a history of cancer, except for non-melanoma skin cancer in past 5 years * Addicted to drugs and/or alcohol (\>4 drinks/day) * Have been exposed to any non-registered drug product within last 30 days. * Working overnight (e.g. 3rd shift of overnight workers) * Excessive exercisers or trained athletes * Have allergies/intolerances to any of the study products. * Extreme dietary habits (ie. vegetarian/vegan) * Excessive coffee/tea drinker (\>4 cups/day) * Actively losing weight/ trying to lose weight (unstable body weight fluctuations of \> 5 kg in 3 months) * Donated blood within last 3 months * Participated in a clinical trial within 1 month * Female who is pregnant, planning to be pregnant, breastfeeding * Any condition the Investigator believes would interfere with his or her ability to provide informed consent or comply with the study protocol, or which might confound
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Clinical Nutrition Research Center
Chicago, Illinois, 60616, United States
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Other studies related to the condition(s) this trial covers.
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