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New weight loss drugs enter human testing – could they beat placebo?

NCT ID NCT07575932

Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 8 times

Summary

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, for weight loss in adults with overweight or obesity. About 872 participants will receive either the drugs or a placebo injection. The main goal is to see how much weight they lose over time and check for side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PF-08653945 and PF-08653944 (injectable drugs for weight loss)
What this could lead to
If successful, this could lead to new medication options for weight loss in people with overweight or obesity.
What could go wrong
This is an early Phase 2 trial, so the drugs may not work better than placebo or could have side effects. Results are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

940 people

The number who actually took part.

Started

May 2026

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Eligible participants for this study include: * adults aged 18 years or older with * obesity (BMI of 30.0 kg/m2 to 50.0 kg/m2) or with * overweight (BMI of 27.0 kg/m2 to \<30.0 kg/m2) who also have at least 1 prespecified weight-related comorbidity (hypertension, dyslipidemia, cardiovascular disease, or obstructive sleep apnea), at the screening visit. Exclusion Criteria: Participants who are not eligible include those with diabetes mellitus, a body weight change of \>5% or use of weight loss medications in the 12 weeks prior to screening, a history of or plan for surgical treatment for obesity, and those who are unable or unwilling to comply with contraceptive requirements or are pregnant or lactating.

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Conditions

The condition(s) this trial relates to.

Body Weight Nutritional and Metabolic Diseases nutritional disorder Obesity obesity disorder overnutrition Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Body weight Nutrition disorders Nutritional and metabolic diseases Obesity Overnutrition Overweight Overweight and/or obesity Overweight or obesity

Contacts and locations

Locations

  • 3A Research

    Plano, Texas, 75093, United States

  • AB Clinical Trials

    Las Vegas, Nevada, 89119, United States

  • AGA Clinical Trials

    Hialeah, Florida, 33012, United States

  • Accellacare - Wilmington

    Wilmington, North Carolina, 28401, United States

  • Activian Clinical Research

    Kingwood, Texas, 77339, United States

  • Aggarwal and Associates Limited

    Brampton, Ontario, L6T 0G1, Canada

  • Alliance Clinical Research Las Vegas (Excel Clinical Research)

    Las Vegas, Nevada, 89109, United States

  • Alpine Medical Group

    Salt Lake City, Utah, 84102, United States

  • Ark Clinical Research

    Fountain Valley, California, 92708, United States

  • Ark Clinical Research

    Long Beach, California, 90815, United States

  • Atlanta Diabetes Associates

    Atlanta, Georgia, 30318, United States

  • Bioluminux Clinical Research

    Hamilton, New Jersey, 08690, United States

  • Bioluminux Clinical Research Illinois

    Naperville, Illinois, 60540, United States

  • Bluewater Clinical Research Group Inc.

    Sarnia, Ontario, N7T 4X3, Canada

  • Cedar Health Research - Euless

    Euless, Texas, 76040, United States

  • Centricity Research Etobicoke Endocrinology

    Etobicoke, Ontario, M9R 4E1, Canada

  • Centricity Research Mirabel Multispecialty

    Mirabel, Quebec, J7J 2K8, Canada

  • Centricity Research Toronto Manna Multispecialty

    Toronto, Ontario, M9W 4L6, Canada

  • Charter Research

    Orlando, Florida, 32803, United States

  • Clinical Research Atlanta

    Stockbridge, Georgia, 30281, United States

  • Clinical Research Institute of Arizona

    Sun City West, Arizona, 85375, United States

  • Collaborative Neuroscience Research, LLC

    Los Alamitos, California, 90720, United States

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231, United States

  • DM Clinical Research

    Tomball, Texas, 77375, United States

  • DelRicht Research

    Mandeville, Louisiana, 70471, United States

  • DelRicht Research

    Prairieville, Louisiana, 70769, United States

  • DelRicht Research

    Springfield, Missouri, 65807, United States

  • DelRicht Research

    Charlotte, North Carolina, 28211, United States

  • DelRicht Research

    Hendersonville, Tennessee, 37075, United States

  • DelRicht Research

    Vienna, Virginia, 22182, United States

  • DelRicht Research @ Zomnir Family Medicine

    Prosper, Texas, 75078, United States

  • Diablo Clinical Research, LLC dba Flourish Research

    Walnut Creek, California, 94598, United States

  • Dr. Anil K. Gupta Medicine Professional Corporation

    Toronto, Ontario, M9V 4B4, Canada

  • Ecogene-21

    Chicoutimi, Quebec, G7H 7K9, Canada

  • JCCT-JUNO NW Houston

    Houston, Texas, 77040, United States

  • Johnson County Clinical Trials

    Lenexa, Kansas, 66219, United States

  • Koch Family Medicine Clinical Research/Elite Research Network

    Morton, Illinois, 61550, United States

  • Manassas Clinical Research Center

    Manassas, Virginia, 20110, United States

  • Mercury Street Medical Group, PLLC

    Butte, Montana, 59701, United States

  • Milestone Research Inc.

    London, Ontario, N5W 6A2, Canada

  • Monroe Biomedical Research

    Monroe, North Carolina, 28112, United States

  • New Horizon Research Center

    Miami, Florida, 33165, United States

  • Palm Research Center

    Las Vegas, Nevada, 89128, United States

  • Paradigm Clinical Research Centers, LLC

    San Diego, California, 92108, United States

  • Paradigm Clinical Research-Modesto

    Modesto, California, 95355, United States

  • Paragon Rx Clinical

    Garden Grove, California, 92840, United States

  • Patient First Clinical Trials (PFCTRIALS)

    Lutherville, Maryland, 21093, United States

  • Piedmont Healthcare

    Statesville, North Carolina, 28625, United States

  • Preferred Primary Care Physicians

    Pittsburgh, Pennsylvania, 15236, United States

  • Preferred Primary Care Physicians

    Uniontown, Pennsylvania, 15401, United States

  • Preferred Primary Care Physicians, Inc.

    Uniontown, Pennsylvania, 15401, United States

  • Recherche GCP Research

    Montreal, Quebec, H1Y 3H5, Canada

  • San Fernando Valley Health Institute

    Canoga Park, California, 91304, United States

  • TMA Headlands LLC (d/b/a Trial Management Associates)

    Myrtle Beach, South Carolina, 29572, United States

  • Tekton Research, LLC.

    Oklahoma City, Oklahoma, 73134, United States

  • Tekton Research, LLC.

    San Antonio, Texas, 78258, United States

  • Torrance Clinical Research Institute, Inc.

    Lomita, California, 90717, United States

  • University Clinical Investigators, Incorporated

    Tustin, California, 92780, United States

  • Viable Clinical Research Corporation

    Bridgewater, Nova Scotia, B4V 3N2, Canada

  • Wasatch Clinical Research, LLC

    Salt Lake City, Utah, 84107, United States

  • Washington Center for Weight Management and Research

    Arlington, Virginia, 22206, United States

  • Westside Center for Clinical Research

    Jacksonville, Florida, 32205, United States

  • Worldwide Clinical Trials

    San Antonio, Texas, 78217, United States

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