OVERWEIGHT AND/OR OBESITY

This study tests a new medicine called MET097, given as a weekly shot, to help adults who are overweight or have obesity and type 2 diabetes lose weight. About 1,000 people will take part; two-thirds get the real medicine and one-third get a placebo. The study lasts about 21 mont…

This study is testing an experimental oral tablet called ecnoglutide to see if it is safe and helps with weight loss. About 84 Chinese adults with a BMI between 24 and 35 will take either the drug or a placebo. The main goal is to check for side effects, and researchers will also…

This study tests whether a 6-month program of dietary counseling and group exercise can reduce heart disease risk in people with severe mental illnesses like schizophrenia or bipolar disorder. About 70 adults will either receive the lifestyle program plus usual care, or usual car…

This study tests a new, non-surgical stomach procedure called Endoscopic Radial Compression Gastroplasty (ERCG) combined with lifestyle changes for weight loss in Chinese adults who are overweight or have mild-to-moderate obesity. The procedure uses a clip-and-loop system to redu…

This study tests a family-based program that uses a mobile app and coaching to help prevent obesity in school-age children. Researchers will work with 40 families in Sonora, Mexico, to improve eating habits, physical activity, and parenting skills. The goal is to see if this appr…

This study tests whether a daily dietary supplement containing fiber and plant compounds can reduce brain inflammation in overweight women going through menopause. The goal is to see if changing gut bacteria through diet can protect brain health and lower the risk of cognitive de…

This study tests whether a supervised, equipment-free high-intensity interval training program can improve heart and muscle fitness in adults who are overweight. Forty participants aged 18 to 55 with a BMI between 25 and 35 will do body-weight exercises in small groups for 10 wee…

This study tests whether adding a friendly AI chatbot to a 12-week smartphone weight loss program helps young adults (ages 18-35) with overweight or obesity lose more weight and stay more engaged. Twenty participants will either get the standard program with daily messages or the…

This early-stage study tests a medicine called PF-08653944 in 20 adults who are overweight or have obesity. The goal is to see how it changes the speed at which the stomach empties food after a meal. Researchers will also check for side effects. The results will help plan future …