Nutritional and metabolic diseases

This study tests whether a drug called AMX0035 can improve how the body responds to insulin in adults with type 1 diabetes. Participants take either AMX0035 or a placebo daily for 24 weeks. Researchers measure insulin sensitivity using a glucose clamp test and track blood sugar c…

This study tests a once-daily pill called orforglipron in adults with type 2 diabetes who plan to fast during Ramadan. The goal is to see if the drug helps control blood sugar and weight without causing harm. About 130 participants will take the pill for up to 48 weeks, with clin…

This study is testing whether a special chewing gum containing galactooligosaccharides (GOS) can help overweight adults lose weight and improve their metabolism. Researchers will measure changes in body mass index (BMI), blood pressure, and gut bacteria over time. The study aims …

This pilot study tests whether a 12-week family-centered, non-calorie restricted whole foods diet can help prevent type 2 diabetes in adults with prediabetes. About 30 adult-child pairs will participate, with adults having prediabetes and children aged 6-18. The study measures fe…

This study from the University of Oxford looks at how eating a diet very high in either carbohydrates or fats (65% of calories) changes blood fat levels and liver fat in 60 healthy adults. Participants will follow one of two diets for a short time, and researchers will measure ch…

This study looks at why many people with Parkinson's disease eat more sugary foods. Researchers will give 50 participants a sugary drink or a placebo on different days, then measure blood sugar, insulin, and movement symptoms. The goal is to see if fast-acting sugars temporarily …