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Carbs vs fats: which diet is better for your heart? oxford launches new study

NCT ID NCT05973539

Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study from the University of Oxford looks at how eating a diet very high in either carbohydrates or fats (65% of calories) changes blood fat levels and liver fat in 60 healthy adults. Participants will follow one of two diets for a short time, and researchers will measure changes in triglycerides and liver fat using blood tests and MRI. The goal is to understand which diet composition may lower the risk of heart disease and diabetes, and whether a person's genes play a role.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Diet: eucaloric diet enriched in either carbohydrates or fat (both contributing to 65% total energy intake)
What this could lead to
If successful, this study could help identify which diet composition is better for heart and metabolic health, and how genes influence that.
What could go wrong
This is a small, early-stage observational study (60 participants) that does not test a treatment. Results may not apply to everyone and won't directly change medical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2023

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male or Female, aged ≥18 to ≤65 years * Body mass index (BMI) ≥19 to ≤35 kg/m2 * No medical condition or relevant drug therapy that is known to affect the liver, adipose tissue, or cardiac metabolism. * Weight stable for the previous 3 months Exclusion Criteria: * Aged \<18 or \>65 years * BMI \<19 or \>35 kg/m2 * A blood haemoglobin \<135 mg/dL for men and \<120 mg/dL for women * Donated (or lost) ≥250 mL of blood in the previous two months * On a weight loss diet or decreased their body weight by \>5% in the previous 3 months * Currently adhering to or have consumed in the previous 3 months a diet with a notably altered macro-nutrient content (e.g. high-fat - low-carbohydrate diet) * Have increased their body weight by \>5% in the previous 3 months * Any metabolic condition or relevant drug therapy * Current smoker * History of alcoholism or a greater than recommended alcohol intake (\>30 g of alcohol daily for men and \>20 g of alcohol daily for women) * History of albumin allergy. * Pregnant or nursing mothers * History of severe claustrophobia

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Conditions

The condition(s) this trial relates to.

Nutritional and Metabolic Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nutritional and metabolic diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Oxford Centre for Diabetes, Endocrinology and Metabolism

    RECRUITING

    Oxford, OX3 7LE, United Kingdom

  • Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford

    RECRUITING

    Oxford, OX3 7LE, United Kingdom

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