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Fat Tissue's role in blood sugar: new study targets obesity mystery

NCT ID NCT02994459

Knowledge-focused Sponsor: University of Missouri-Columbia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how fat tissue takes up sugar in people with obesity, comparing those with normal blood sugar to those with insulin resistance. Researchers will use labeled sugar infusions and PET scans to measure sugar uptake in fat and muscle. The goal is to understand why some obese individuals stay metabolically healthy while others do not. A small weight-loss program is included for obese participants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
diet-induced weight loss
What this could lead to
If successful, this study could clarify why some people with obesity maintain normal blood sugar, potentially guiding personalized treatments for metabolic health.
What could go wrong
This is an observational study with a small sample size (90 participants). It does not test a new drug or therapy, so direct patient benefits are not expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2017

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The investigators plan to study a total of 45 men and women of all races and ethnic groups: 15 MAO (metabolically abnormal obese, likely insulin resistant), 15 MNO (metabolically normal obese, likely insulin sensitive), and 15 lean. All three groups will be balanced with regards to sex and race/ethnicity distribution, and the two obese groups will also be matched on percent total body fat. They will also attempt to recruit 15 metabolically abnormal lean participants.

Ages

18 to 64 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: All subjects * Age: greater than or equal to 18 years but \<65 years * Weight stable (i.e., ±2 kg for at least 3 months) * Sedentary (less than 1 hour of structured exercise per week) * No evidence of significant organ system dysfunction or disease (e.g., diabetes, impaired kidney function, cancer, etc.) In addition, subjects must fulfill all of the following inclusion criteria. Metabolically Normal Lean * BMI greater than or equal to 18.5 but \<25.0 kg/m2 * Fasting blood glucose: \<100 mg/dl * Blood glucose 2 h after an OGTT: \<140 mg/dl * HbA1c \<5.7 %. Metabolically Normal Obese, likely insulin sensitive * BMI greater than or equal to 30.0 but \<45.0 kg/m2 * Fasting blood glucose: \<100 mg/dl * Fasting insulin: \<20 mU/l * Blood glucose 2 h after an OGTT: \<140 mg/dl * HbA1c \<5.7 %. Metabolically Abnormal Obese, likely insulin resistant * BMI greater than or equal to 30.0 but \<45.0 kg/m2 * Fasting blood glucose ≥100 mg/dl or blood glucose 2 h after an OGTT ≥140 mg/dl or fasting insulin \>20 µU/mL or HbA1c \>5.7 %. Metabolically Abnormal Lean * BMI greater than or equal to 18.5 but \<25.0 kg/m2 * Fasting blood glucose ≥100 mg/dl or blood glucose 2 h after an OGTT ≥140 mg/dl or fasting insulin \>20 µU/mL or HbA1c \>5.7 %.

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Conditions

The condition(s) this trial relates to.

glucose metabolism disease obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Glucose metabolism disorders

Contacts and locations

Locations

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.