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Diet vs. surgery: which weight loss method changes metabolism more?

NCT ID NCT03091725

Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 26, 2026 · Updated 2 times

Summary

This study looks at how the body handles different types of meals after losing about 16-18% of body weight through either a low-calorie diet or gastric bypass surgery. Researchers will measure insulin, blood sugar, fats, and other markers in 30 adults with obesity but without diabetes. The goal is to understand how each weight loss method affects metabolism, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Roux-en-Y gastric bypass surgery and low-calorie diet
What this could lead to
If successful, this study could help explain why some weight-loss methods improve metabolism more than others, potentially guiding better obesity treatments.
What could go wrong
This is a small, early-stage observational study with only 30 participants, so results may not apply to everyone. It does not test a new drug or treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2017

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Surgery Group (RYGB): * Males and Females * Scheduled for RYGB surgery * Body Mass Index 35-60 kg/m² * Without Type 2 Diabetes (T2D) LCD group: * Males and Females * Body Mass Index 35-60 kg/m² * Without Type 2 Diabetes (T2D) Exclusion Criteria: * Regular use of tobacco products * Previous intestinal resection * Pregnant or breastfeeding * Evidence of significant organ system dysfunction or disease other than obesity and T2D * Use of any medication that might, in the opinion of the investigator, affect metabolic function * Exercise ≥90 minutes per week * Use or past use of hormone replacement therapy within the past 6 months

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

Contacts and locations

Locations

  • Beth Henk

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.