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Why losing weight gets harder: scientists investigate the hidden role of liver and kidney size

NCT ID NCT07415213

Knowledge-focused Sponsor: Tel Aviv University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why people who lose weight often experience a greater-than-expected slowdown in metabolism, making it harder to keep weight off. Researchers will compare three lifestyle approaches—resistance training, calorie restriction, and time-restricted eating—in 75 overweight adults over 10 weeks. They will measure changes in liver and kidney size, resting metabolism, and body composition to better understand the biological reasons behind metabolic adaptation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 75 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Sedentary men and women aged 25-60 years * Body mass index (BMI) of 25-35 kg/m² Exclusion Criteria: * Participation in another exercise or weight loss program in the last 6 months * Non-stable weight (\>±5%) over the past 6 months * Smoking within the past 6 months * Post-menopause * Breastfeeding * Pregnancy or having been pregnant within the past 6 months * Contraindication for MRI scans (e.g., tattoos, intrauterine devices, permanent makeup, etc.) * Severe cardiopulmonary disease (e.g., recent myocardial infarction or unstable angina) * Musculoskeletal or neuromuscular impairments that preclude exercise training * Cognitive impairments * Other health issues, including cancer, diabetes, thyroid disease, hypertension, or chronic renal failure * Use of drugs that affect body metabolism * Secondary liver disease (viral, autoimmune, alcoholic, or hepatotoxic) * Alcohol consumption above 20 g/day for women or 30 g/day for men

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Energy metabolism Overweight/obesity

Contacts and locations

Locations

  • Sylvan Adams Sport Institute

    Tel Aviv, 69978, Israel

More trials for these conditions

Other studies related to the condition(s) this trial covers.