Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Cutting calories could reshape muscle fat and boost insulin response

NCT ID NCT00993460

Knowledge-focused Sponsor: Vanderbilt University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study investigates how severe calorie restriction—achieved through weight-loss surgery—changes the types of fat stored in muscle and how muscles respond to insulin. Researchers will compare normal-weight participants with those who are obese and scheduled for gastric bypass. The goal is to understand whether reducing calories lowers harmful saturated fats in muscle and improves the body's ability to manage blood sugar.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
caloric restriction (via Roux-en-Y gastric bypass)
What this could lead to
If successful, this could reveal how reducing calories changes muscle fat composition and improves insulin sensitivity, pointing toward better treatments for obesity-related insulin resistance.
What could go wrong
This is a small, early-stage observational study (24 participants) that measures biological changes, not a treatment trial. Results may not apply to everyone, and the findings are exploratory.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Start date

Mar 2011

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Female subjects approved for Roux-en-Y gastric bypass surgery at Vanderbilt University Medical Center.

Ages

21 to 65 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * For Normal Weight Subjects: * Age 21-65 years * BMI of 21 to 27 kg/m2 * Normal glucose tolerance as determined by OGTT on day of screening * No family history of diabetes * For Morbidly Obese Subjects: * Age 21-65 years * BMI of 30 to 65 kg/m2 * Scheduled for Roux-en-Y gastric bypass at Vanderbilt Medical Center * Insulin resistant as determined by OGTT on day of screening Exclusion Criteria (for all subjects): * Clinically significant heart disease * Clinically significant hepatic or renal disease * Pregnancy * Breastfeeding * Any abnormality that would preclude safe completion of study * Use of statins * Use of thiazide or furosemide diuretics, beta blockers, or other chronic medications with known adverse effects on glucose tolerance levels unless subject has been on stable dose of such medications for the past 3 months before entering the study

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Obesity are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Inflammation Insulin Resistance Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

Contacts and locations

Locations

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.