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New weekly shot could help shed pounds in major obesity trial

NCT ID NCT07311850

Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 04, 2026 · Updated 7 times

Summary

This large phase 3 trial is testing a new once-weekly injection called MET097 for weight loss in 3501 adults with obesity or overweight (but without diabetes). Participants will receive either the drug or a placebo for up to 84 weeks. The main goal is to see how much weight people lose after 64 weeks of treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MET097 (a once-weekly injection that mimics a natural hormone to help with weight loss)
What this could lead to
If it works, this could offer a new, convenient once-weekly treatment option for significant and sustained weight loss in people with obesity or overweight.
What could go wrong
This is a phase 3 trial, but results are not yet known. Weight loss may be modest for some, and side effects like nausea or rare thyroid tumors are possible. It is not a cure for obesity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

3,578 people

The number who actually took part.

Started

Dec 2025

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI ≥ 30 kg/m2 or BMI ≥ 27.0 kg/m2 to \<30.0 kg/m2 and presence of at least 1 of the following weight- related comorbidities: Hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease) Exclusion Criteria: * Have any form of diabetes * Have a self-reported body weight change \> 5 kg (11 pounds) within 3 months prior to Screening * Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) * History of chronic pancreatitis or presence of acute pancreatitis within the past 180 days prior to the Screening visit; or active/current, symptomatic gallbladder disease

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity and overweight

Contacts and locations

Locations

  • Advanced Clinical Research

    Miami, Florida, 33156, United States

  • Alliance Research Institute

    Canoga Park, California, 91304, United States

  • AmBeNet GmbH

    Leipzig, 4107, Germany

  • Ashfields Primary Care Center

    Sandbach, Cheshire, CW11 1EQ, United Kingdom

  • Bodyline Medical Clinic Warrington Civia Health

    Paddington, WA1 3TZ, United Kingdom

  • Bodyline Medical Clinic, Crosby Civia Health

    Liverpool, L22 4QQ, United Kingdom

  • Bodyline Medical Clinic, St Helens Civia Health

    St Helens, WA9 1AF, United Kingdom

  • Bodyline Medical Clinic, Stoke-on-Trent Civia Health

    Stoke-on-Trent, ST1 5TL, United Kingdom

  • CCR Ostrava

    Ostrava, 702 00, Czechia

  • CDG Studienambulanz Hartard

    Munich, Bavaria, 80809, Germany

  • Cardio D&R Košice

    Košice, 040 22, Slovakia

  • Cedar Health Research

    Dallas, Texas, 75251, United States

  • CenExcel Rocky Mountain Clinical Research, LLC

    Englewood, Colorado, 80113, United States

  • CenExel CBH Health

    Gaithersburg, Maryland, 20877, United States

  • CenExel FCR - ForCare Clinical Research

    Tampa, Florida, 33613, United States

  • CenExel iResearch, LLC

    Savannah, Georgia, 31405, United States

  • Centricity Research Etobicoke Endocrinology

    Etobicoke, Ontario, M9R 4E1, Canada

  • Centricity Research Mirabel Multispecialty (Centricity Research)

    Mirabel, Quebec, J7J 2K8, Canada

  • Centru Medical "GRANDMED"

    Oradea, 410032, Romania

  • Centrul Medical Mediab - Mediab Srl

    Târgu Mureş, 540142, Romania

  • Centrum Badan Klinicznych PI-House Sp. z o.o.

    Gdansk, 80-546, Poland

  • Centrum Medyczne Pratia Gdynia

    Gdynia, 81-338, Poland

  • Centrum Medyczne Pratia Katowice

    Katowice, 40-081, Poland

  • Centrum Terapii Współczesnej J.M. Jasnorzewska Spółka Komandytowo-Akcyjna

    Lodz, 90-338, Poland

  • Centrum medyczne Pratia Bydgoszcz

    Bydgoszcz, 85-796, Poland

  • Civia Health Goodlettsville

    Goodlettsville, Tennessee, 37072, United States

  • Civia Health Memphis

    Memphis, Tennessee, 38117, United States

  • Civia Health Nashville

    La Vergne, Tennessee, 37086, United States

  • Civia Health Sunderland

    Hendon, CITY of Sunderland, SR1 1PB, United Kingdom

  • Civia Health_Boots Birmingham

    Birmingham, B4 7TA, United Kingdom

  • Civia Health_Boots Nottingham

    Nottingham, NG1 3QS,, United Kingdom

  • Clifton Medical Centre

    Rotherham, S65 2EN, United Kingdom

  • Clinical Innovations, Inc dba CITrials

    Riverside, California, 92506, United States

  • Clinical Research Professionals

    Chesterfield, Missouri, 63005, United States

  • Collaborative Neuroscience Research, LLC

    Torrance, California, 90504, United States

  • DIABEDA s.r.o.

    Bratislava, 831 06, Slovakia

  • Dallas Clinical Research Center (Pillar Clinical Research)

    Richardson, Texas, 75080, United States

  • DelRicht Research

    Atlanta, Georgia, 30329, United States

  • Diabetes Practice Dr. Braun

    Berlin, 13187, Germany

  • Diabeteszentrum Hamburg-West

    Hamburg, 22607, Germany

  • Diagnostic Consultative Center Aleksandrovska

    Sofia, 1431, Bulgaria

  • ETG Siedlce

    Siedlce, 08-110, Poland

  • Ecg Médica S.L.

    Valencia, 46015, Spain

  • Edumed s.r.o.

    Náchod, 54701, Czechia

  • Ekamed Sp. z o. o.

    Lublin, 20-718, Poland

  • Etg Warszawa

    Warsaw, 02-677, Poland

  • Eximia EquiHealth Research

    Durham, North Carolina, 27704, United States

  • Fakultní nemocnice Královské Vinohrady

    Prague, 100 34, Czechia

  • Forum Austin (Civia Health)

    Austin, Texas, 78758, United States

  • Forum Health_Cary (Civia)

    Cary, North Carolina, 27511, United States

  • Fundatia Dr Victor Babes

    Bucharest, 30303, Romania

  • Future Medical Research (Civia Health)

    Longwood, Florida, 32750, United States

  • FutureMeds Berlin

    Berlin, 10629, Germany

  • FutureMeds Birmingham

    Birmingham, B21 9RY, United Kingdom

  • FutureMeds Frankfurt/Offenbach

    Offenbach, 63065, Germany

  • FutureMeds Gdynia

    Gdynia, 81-384, Poland

  • FutureMeds Glasgow McCafferty House

    Glasgow, Scotland, G20 7BE, United Kingdom

  • FutureMeds Krakow

    Krakow, 31-501, Poland

  • FutureMeds Liverpool

    Bromborough, CH62 6EE, United Kingdom

  • FutureMeds Lodz

    Lodz, 91-393, Poland

  • FutureMeds London

    London, NW10 2PB, United Kingdom

  • FutureMeds Newcastle upon Tyne

    Newcastle upon Tyne, NE6 1SG, United Kingdom

  • FutureMeds Olsztyn

    Olsztyn, 10-165, Poland

  • FutureMeds Teesside

    Stockton, TS19 8PE, United Kingdom

  • FutureMeds Warszawa Centrum

    Warsaw, 00-215, Poland

  • FutureMeds Warszawa Targowek

    Warsaw, 03-291, Poland

  • FutureMeds Wroclaw

    Wroclaw, 53-673, Poland

  • Futuremeds S.R.L., Brasov

    Brasov, 500388, Romania

  • Futuremeds S.R.L., Craiova

    Criaova, 200115, Romania

  • Futuremeds S.R.L., Galati

    Galati, 800183, Romania

  • Futuremeds Spain Cadiz

    Chiclana de la Frontera, 11139, Spain

  • Futuremeds Spain Madrid

    Madrid, 28003, Spain

  • Futuremeds Spain Sevilla

    Seville, 41012, Spain

  • GLRI El Paso Research

    El Paso, Texas, 79936, United States

  • Gemeinschaftspraxis Dres. H.Kittner und K.Hartig

    Naunhof, 04683, Germany

  • Hassman Research Institute

    Marlton, New Jersey, 08053, United States

  • Headlands Research

    Scottsdale, Arizona, 85260, United States

  • Hightech Medical Services S.R.L (Centrul pentru Studiul Metabolismului)

    Bucharest, 011053, Romania

  • Hospital Universitario Virgen de la Victoria

    Málaga, Málaga, 29010, Spain

  • Hospital Virgen del Camino

    Sanlúcar de Barrameda, 11540, Spain

  • Hospital Vithas Sevilla

    Castilleja de la Cuesta, 41950, Spain

  • IRMED

    Piotrkow Trybunalski, 97-300, Poland

  • Institutul Clinic Fundeni

    Bucharest, 022328, Romania

  • Institutul National de Endocrinologie "C.I. Parhon"

    Bucharest, 011863, Romania

  • Instytut Diabetologii.sp.z.o.o.

    Warsaw, 02-117, Poland

  • JAL s.r.o

    Trnava, 91701, Slovakia

  • Kiltearn Medical Centre

    Nantwich, CW5 5NX, United Kingdom

  • Klinische Forschung Berlin-Mitte GmbH

    Berlin, 10117, Germany

  • Klinische Forschung Dresden GmbH / Pratia

    Dresden, 01069, Germany

  • Klinische Forschung Hamburg GmbH / Pratia

    Hamburg, 20253, Germany

  • Klinische Forschung Karlsruhe GmbH

    Karlsruhe, 76137, Germany

  • LMC Diabetes & Endocrinology - Bayview (Centricity Research Toronto LMC Multispecialty)

    Toronto, Ontario, M4G 3E8, Canada

  • MC Nevromedics Ltd.

    Veliko Tarnovo, 5005, Bulgaria

  • MEDI-DIA s.r.o

    Sabinov, 083 01, Slovakia

  • MHAT Botevgrad

    Botevgrad, 2140, Bulgaria

  • MHAT Sveta Karidad EAD

    Plovdiv, 4004, Bulgaria

  • Medical Center - Clinic Nova EOOD

    Varna, 9020, Bulgaria

  • Medical Center 4Life EOOD

    Burgas, 8018, Bulgaria

  • Medical Center Berbatov

    Yambol, 8600, Bulgaria

  • Medical Center Futuremeds EOOD

    Plovdiv, 4000, Bulgaria

  • Medical Center Hera EOOD

    Sofia, 1510, Bulgaria

  • Medical Center New Polyclinic Gabrovo Ltd.

    Gabrovo, 5300, Bulgaria

  • Medical Center Zdrave 1

    Kozloduy, 3320, Bulgaria

  • Medical Centre Pratia Clinic EOOD

    Varna, 9020, Bulgaria

  • Medical group Kosice s.r.o.

    Košice, 04001, Slovakia

  • Medicome Sp. z o.o. Oświęcimskie Centrum Badań Klinicznych

    Oświęcim, 32-600, Poland

  • Medislim GmbH

    Weinheim, 69469, Germany

  • Medispektrum s.r.o.

    Bratislava, 85101, Slovakia

  • Medivasa s.r.o

    Žilina, 010 01, Slovakia

  • Medizentrum Essen Borbeck

    Essen, 45355, Germany

  • Metabolica Sp. z o.o., NZOZ METABOLICA Ośrodek Badań Klinicznych

    Tarnów, 33-100, Poland

  • Minimed S.R.L.

    Bacau, 600237, Romania

  • Multiprofile Hospital for Active Treatment Dobrich AD (MHAT Dobrich AD)

    Dobrich, 9300, Bulgaria

  • NZOZ Centrum Medyczne KERmed

    Bydgoszcz, 85-231, Poland

  • Nuevas Tecnologías en Diabetes y Endocrinología S.L.

    Seville, 41003, Spain

  • Oviedo Medical Research

    Oviedo, Florida, 32765, United States

  • Palmetto Internal Medicine

    Mauldin, South Carolina, 29662, United States

  • Pantheon Clinical Research

    Bountiful, Utah, 84010, United States

  • Panthera Biopartners Limited - Enfield

    Enfield, EN3 4GS, United Kingdom

  • Panthera Biopartners Limited - Glasgow

    Glasgow, G51 4TY, United Kingdom

  • Panthera Biopartners Limited - Preston

    Preston, PR2 9QB, United Kingdom

  • Panthera Biopartners Limited - Rochdale

    Rochdale, OL11 4AU, United Kingdom

  • Panthera Biopartners Limited - Sheffield

    Sheffield, S2 5FX, United Kingdom

  • Panthera Biopartners Limited - York

    York, YO24 4LJ, United Kingdom

  • Peninsula Headlands LLC

    Rolling Hills, California, 90274, United States

  • Poliklinika Váš Lekár

    Bratislava - Ružinov, 91109, Slovakia

  • Praktyka Lekarska Ewa Krzyzagorska

    Poznan, 61-655, Poland

  • Pratia Brno,s.r.o

    Brno, 60200, Czechia

  • Pratia Chojnice

    Chojnice, 89-600, Poland

  • Pratia Pardubice

    Pardubice, 53002, Czechia

  • Praxis Reinfeld Mitte

    Holstein, 23858, Germany

  • Praxis am Markt - Dr. Bernd Becker

    Essen, 45355, Germany

  • Prevencia - 2000 - Medical Center for Prehospital Medical Care OOD

    Stara Zagora, 6000, Bulgaria

  • Primary clinical Research

    Papillion, Nebraska, 68046, United States

  • Quality Clinical Research Inc

    Omaha, Nebraska, 68114, United States

  • ResTrial s.r.o.

    Prague, 18100, Czechia

  • Research Centers of America

    Hollywood, Florida, 33024, United States

  • Rolling Oaks Radiology -Palms

    Oxnard, California, 93036, United States

  • Sahana Optometry PLLC dba Family Eye Wellness

    Holly Springs, North Carolina, 27540, United States

  • Santa Familia PTG Lodz

    Lodz, Łódź Voivodeship, 90-302, Poland

  • Sc Gensan Srl/Policlinica Astra

    Sibiu, 550371, Romania

  • Southmead Hospital

    Bristol, BS10 5NB, United Kingdom

  • Studienzentrum FMZ Radowsky

    Leipzig, Saxony, 4179, Germany

  • Summit Headlands LLC

    Portland, Oregon, 97210, United States

  • Synexus Glasgow Clinical Research Centre

    Bellshill, ML4 3NJ, United Kingdom

  • Synexus Manchester Clinical Research Centre

    Manchester, M15 6SE, United Kingdom

  • Synexus Midlands Clinical Research Centre

    Edgbaston, B16 8QQ, United Kingdom

  • Synexus Polska Sp z o.o.

    Gdansk, 80-382, Poland

  • Synexus Polska Sp. Z O.O. Oddzial W Katowicach

    Katowice, 40-040, Poland

  • Synexus Polska Sp. z o.o. Oddzial w Gdyni

    Gdynia, 81-537, Poland

  • Synexus Polska Sp. z o.o., Oddzial w Czestochowie

    Częstochowa, 42-202, Poland

  • Synexus Polska Sp. z o.o., Oddzial w Lodzi

    Lodz, 90-127, Poland

  • Synexus Polska Sp. z o.o., Oddzial w Warszawie

    Warsaw, 02-672, Poland

  • Synexus Polska Sp. z o.o., Oddział w Poznaniu

    Poznan, 60-702, Poland

  • Synexus Polska Sp. z o.o., Oddział we Wrocławiu

    Wroclaw, 50-381, Poland

  • Synexus/Trialmed Prague

    Prague, 120 00, Czechia

  • TMA Headlands LLC

    Wilmington, North Carolina, 28403, United States

  • TMA Headlands LLC - Wilmington

    Wilmington, North Carolina, 28403, United States

  • Tatratrial s.r.o.

    Rožňava, 048 01, Slovakia

  • The Wharton Medical Clinic Clinical Trials Inc

    Hamilton, Ontario, L8L 5G8, Canada

  • Trialmed CRS

    Piotrkow Trybunalski, 97-300, Poland

  • Tribe Clinical Research LLC. - Spartanburg

    Spartanburg, South Carolina, 29301, United States

  • Tribe Clinical Research LLC.- Greenville

    Greenville, South Carolina, 29607, United States

  • Upgrade Performance Institute

    Elkhorn, Nebraska, 68022, United States

  • Velocity Clinical Research Germany

    Berlin, 10787, Germany

  • Zdrowie Osteo Medic sc L i A Racewicz, A i J Supronik

    Bialystok, 15-351, Poland

  • Zentrum für klinische Forschung

    Cologne, 51069, Germany

  • Zentrum für klinische Forschung Allgäu-Oberschwaben

    Wangen, 88239, Germany

  • Zentrum für klinische Studien Bad Homburg

    Bad Homburg, 61348, Germany

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