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New weekly shot could help shed pounds in obesity trial

NCT ID NCT07503210

Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 5 times

Summary

This study tests whether a new medicine called NNC0487-0111, given as a weekly injection, is safe and effective for weight loss in adults with obesity. About 600 participants will receive either the active drug or a placebo (dummy injection) for comparison. The main goal is to measure the percentage of body weight lost over the study period.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

606 people

The number who actually took part.

Started

Apr 2026

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female (sex at birth). * Age 18 years or above at the time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) greater than or equal to ≥ 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP 1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

Contacts and locations

Locations

  • A.O.Universitaria S.ORSOLA-MALPIGHI - U.O.Endocrinologia e Cura

    Bologna, 40138, Italy

  • AIPSMC Dr. Traykovska EOOD

    Sofia, 1839, Bulgaria

  • AIPSOMCEMD ENDO MED CONSULT 2020 - Dr. Aleksander Botushanov EOOD

    Plovdiv, 4002, Bulgaria

  • AZ Groeninge - Kortrijk - Centrum Endo - Diabetologie

    Kortrijk, 8500, Belgium

  • AZ OOSTENDE (Campus DAMIAAN)

    Ostend, 8400, Belgium

  • Albany House Medical Centre

    Wellingborough, NN8 4RW, United Kingdom

  • Anima Research Center

    Diepenbeek, 3590, Belgium

  • Arcispedale Sant'Anna (Cona) - UO di Endocrinologia

    Ferrara, Emilia-Romagna, 44124, Italy

  • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Civile Maggiore Borgo Trento - U.O. Geriatria

    Verona, Veneto, 37126, Italy

  • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone - Presidio Villa Belmonte

    Palermo, Sicily, 90142, Italy

  • Azienda Ospedaliera di Padova - UOSD Chirurgia Bariatrica

    Padova, Veneto, 35128, Italy

  • CHU DE CLERMONT-FERRAND-HOPITAL GABRIEL MONTPIED_Service de Nutrition

    Clermont-Ferrand, 63000, France

  • CHU DE POITIERS_Centre d'investigation Clinique

    Poitiers, 86000, France

  • CHU GRENOBLE ALPES-SITE NORD MICHALLON_Endocrinologie,diabétologie,maladies de la nutrition

    La Tronche, 38700, France

  • CHU LILLE-HOPITAL CLAUDE HURIEZ_Service de Chirurgie Générale et Endocrinienne

    Lille, 59000, France

  • CICEMO- Consultorio (Av Directorio)

    Ciudad Autónoma de Buenos Aires, Buenos Aires, C1424CIQ, Argentina

  • CIPREC Pueyrredon

    Buenos Aires, C1119ACN, Argentina

  • Centre hospitalier universitaire de Liège (CHU de Liège)

    Liège, 4000, Belgium

  • Centro Periferico De Especialidades Bola Azul

    Almería, 04009, Spain

  • Clifton Medical Centre

    Rotherham, S65 1DA, United Kingdom

  • Clinical Res Collaborative

    Cumberland, Rhode Island, 02864, United States

  • Conexa

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1018ADE, Argentina

  • DCC 1 - Lom EOOD

    Lom, 3600, Bulgaria

  • Diabetologikum - Diabetologische Schwerpunktpraxis Dr. Thomas Segiet

    Speyer, LÄK Rheinland-Pfalz, 67346, Germany

  • Diabetologische Gemeinschaftspraxis Dr. Staudenmeyer und Dr. Schiwietz

    Lingen, 49808, Germany

  • Diablo Clinical Research, Inc.

    Walnut Creek, California, 94598, United States

  • EB Flevo Research BV

    Almere Stad, 1311RL, Netherlands

  • EMS Healthcare

    Macclesfield, North West England, SK10 4TF, United Kingdom

  • Endeavor Health

    Skokie, Illinois, 60077, United States

  • Florida Inst For Clin Res LLC

    Orlando, Florida, 32825, United States

  • Fondazione Salvatore Maugeri I.R.C.C.S. - Pavia - Dipartimento Medicina Interna e Generale

    Pavia, Lombardy, 27100, Italy

  • GROUPE SOS SANTE-HOPITAL LE CREUSOT-HOTEL DIEU_ Service de Diabétologie

    Le Creusot, 71200, France

  • H. Clinico Univ. Virgen de la Victoria

    Málaga, 29010, Spain

  • H. de León_Endocrinología

    León, 24008, Spain

  • H.U. Quirónsalud Madrid

    Pozuelo de Alarcón, 28223, Spain

  • Hospital Clinic i Provincial

    Barcelona, 08036, Spain

  • Hospital Clínico San Carlos

    Madrid, 28040, Spain

  • Hospital Universitario Virgen del Rocío

    Seville, 41013, Spain

  • Hunter Diabetes Centre

    Merewether, New South Wales, 2291, Australia

  • IRCCS Humanitas - U.O. Endocrinologia e Diabetologia

    Rozzano (MI), 20089, Italy

  • IRCCS Ospedale Policlinico San Martino - Medicina Interna e Specialità Mediche

    Genoa, Liguria, 16132, Italy

  • Institut für Diabetesforschung GmbH Münster - Dr. med. Rose

    Münster, 48145, Germany

  • Instituto de Investigaciones Clinicas Mar Del Plata

    Mar del Plata, Buenos Aires, B7600FZN, Argentina

  • MHAT Med Line Clinic

    Plovdiv, 4000, Bulgaria

  • Meander MC

    Amersfoort, 3813 TZ, Netherlands

  • Medical Center Maraya Med EOOD

    Sofia, 1756, Bulgaria

  • Medication Mgmnt, LLC_Grnsboro

    Greensboro, North Carolina, 27405, United States

  • Midwest Inst For Clin Res

    Indianapolis, Indiana, 46260, United States

  • Nightingale Research Adelaide

    Adelaide, South Australia, 5000, Australia

  • North Texas Endocrine Center

    Dallas, Texas, 75231, United States

  • PMG Research of Wilmington LLC

    Wilmington, North Carolina, 28401, United States

  • Pinnacle Research Group LLC

    Anniston, Alabama, 36207, United States

  • PreCare Trial & Recruitment

    Born, Limburg, 6121 XK, Netherlands

  • Prof. Dr. Schiefke Ingolf, EUGASTRO GmbH

    Leipzig, 04103, Germany

  • Progress Clinical Research Den Bosch

    's-Hertogenbosch, North Brabant, 5223 LA, Netherlands

  • RED-Institut für medizinische Forschung und Fortbildung GmbH

    Oldenburg in Holstein, 23758, Germany

  • Rainier Clin Res Ctr Inc

    Renton, Washington, 98057, United States

  • Rijnstate Ziekenhuis

    Arnhem, 6815 AD, Netherlands

  • SGHAT Dr. Shterev EOOD

    Sofia, 1330, Bulgaria

  • Sanos Clinic - Vejle

    Vejle, Region Syddanmark, 7100, Denmark

  • Selma Medical Associates

    Winchester, Virginia, 22601-3834, United States

  • Sjællands Universitetshospital, Køge - Medicinsk Afdeling

    Køge, Region Sjælland, 4600, Denmark

  • Staploe Medical Centre

    Soham, CB7 5JD, United Kingdom

  • Sydney Cardiometabolic Centre

    Liverpool, New South Wales, 2170, Australia

  • Sydney Clinical Trials

    Campbelltown, New South Wales, 2560, Australia

  • Sydvestjysk Sygehus Esbjerg - Medicinsk Endokrinologisk Ambulatorium, Forskningsenheden

    Esbjerg, Region Syddanmark, 6700, Denmark

  • UMHAT Aleksandrovska EAD, Clinic of Endocrinology and Metabolic Diseases

    Sofia, 1431, Bulgaria

  • UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic

    Plovdiv, 4001, Bulgaria

  • UPA Ctr Weight and Eating Dis

    Philadelphia, Pennsylvania, 19104, United States

  • UT Southwestern Med Cntr

    Dallas, Texas, 75390-9302, United States

  • Wendisch - Dahl Hamburg - DZHW

    Hamburg, 22607, Germany

  • Zentrum für klinische Studien Alexander Segner

    Saint Ingbert-Oberwürzbach, 66386, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.